Solvent-cast direct-writing as a fabrication strategy for radiopaque stents

Chausse, Víctor; Schieber, Romain; Raymond, Yago; Ségry, Brian; Sabaté, Ramon; Kolandaivelu, Kumaran; Ginebra, Maria‐Pau; Pegueroles, Marta

doi:10.1016/j.addma.2021.102392

Cited by 16 publications

(23 citation statements)

References 55 publications

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“…This is a result of the evaporation of the solvent during the solidification, which is a characteristic feature of this process. 28 This also leads to material retraction and flattening of the implant. The thickness of the implant was found to be 0.157 ± 0.005 mm postdrying.…”

Section: Resultsmentioning

confidence: 99%

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A 3D-Printed Graphene BioFuse Implant for Postsurgical Adjuvant Therapy of Cancer: Proof of Concept in 2D- and 3D-Spheroid Tumor Models

Anup

Gadeval

Tekade

2023

ACS Appl. Bio Mater.

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Three-dimensional printing is an emerging technology that is finding its niche applications in diverse fields owing to its flexibility concerning personalization and design. Surgery followed by adjuvant therapy is the standard treatment plan in most cancers from stage I to stage III. Most of the available adjuvant therapies, like chemotherapy, radiation therapy, immunotherapy, hormonal therapy, etc., are associated with severe side effects that considerably reduce the quality of life of patients. In addition, there is always the chance of tumor recurrence or metastasis development followed by surgery. This investigation reports the development of a 3D-printed, biodegradable, laser-responsive implant with a chemo-combined thermal ablating potential for adjuvant therapy of cancer. The 3D-printable ink was developed using poly(l-lactide) and hydroxypropyl methylcellulose as the base polymer, doxorubicin as the chemotherapeutic agent, and reduced graphene oxide as the photothermal ablating agent. The personalized implant released the drug pH-dependently (p value < 0.0001) for an extended period (93.55 ± 1.80% → 28 days). The 3D-printed implant exhibited acceptable biophysical properties (tensile strength: 3.85 ± 0.15 MPa; modulus: 92.37 ± 11.50 MPa; thickness: 110 μm) with laser-responsive hyperthermia (ΔT: 37 ± 0.9 °C → 48.5 ± 1.07 °C; 5 min; 1.5 W/cm2) and inherent biodegradable property (SEM analysis). The 3D-printed implant was evaluated for its therapeutic potential in 2D- and 3D-spheroid tumor models (MDA-MB 231 and SCC 084 2D cells) employing MTT cytotoxicity assay, apoptosis assay, cell cycle analysis, and gene expression analysis. The biomolecular aspects and biomechanics of the 3D-printed BioFuse implant were also evaluated by determining the effect of treatment on the expression levels of HSP1A, Hsp70, BAX, and PTEN. It is advocated that the knowledge developed in this project will significantly assist and advance the science aiming to develop a clinically translatable postsurgical adjuvant therapy for cancer.

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Section: Resultsmentioning

confidence: 99%

“…The SEM image depicts the porous surface morphology of the implant (Figure C). This is a result of the evaporation of the solvent during the solidification, which is a characteristic feature of this process . This also leads to material retraction and flattening of the implant.…”

Section: Resultsmentioning

confidence: 99%

A 3D-Printed Graphene BioFuse Implant for Postsurgical Adjuvant Therapy of Cancer: Proof of Concept in 2D- and 3D-Spheroid Tumor Models

Anup

Gadeval

Tekade

2023

ACS Appl. Bio Mater.

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“…PLLA and PLCL stents were manufactured by means of SC-DW technique as reported elsewhere. 39 Briefly, dissolution of PLLA or PLCL pellets in chloroform at a 10% or 12.5% ratio (w/v), respectively, rendered printable inks. Tubular printing was achieved by modification of a BCN 3D+ printer (BCN 3D technologies, Spain) via substitution of its y axis for a 3 mm in diameter rotating mandrel.…”

Section: Methodsmentioning

confidence: 99%

Functionalization of 3D printed polymeric bioresorbable stents with a dual cell-adhesive peptidic platform combining RGDS and YIGSR sequences

et al. 2023

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“…Meanwhile, the combination of the conductive GNP layer and the porous and flexible nature of PUF contributed to the excellent pressure/strain sensor and absorption-dominant EMI shielding. Chloroform (CMF), a widely used solvent in organic synthesis, [41] the extraction of valuable compounds, [42] 3D printing, [43] and the preparation of polyl-lactic acid, [44][45][46] poly(methyl methacrylate), [47,48] or epoxy [49][50][51][52] based composites, was used to demonstrate the proposed coating strategy. This is because CMF possesses two crucial properties that made the process simple and efficient: i) high dispersion capacity for GNP [35] and ii) a low boiling point (66 °C) that facilitated a straightforward process.…”

Section: Introductionmentioning

confidence: 99%

Graphene Nanoplatelet Exoskeleton on Polyurethane Foam to Produce Flame‐Retardant, Piezoresistive, and Electromagnetic Interference Shielding Surfaces

Weldemhret,

Lee,

M.N.

et al. 2023

Adv Materials Inter

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Polyurethane foam (PUF)’s porous structure, light weight, flexibility, and low‐cost properties make it useful in various cutting‐edge technologies. However, time‐consuming, costly, and complicated surface modification methods severely hinder its commercial applications. Herein, an ultrafast, simple, and cost‐effective surface modification method based on the evaporation of a low boiling point solvent to prepare a multifunctional graphene nanoplatelet (GNP)‐decorated PUF (GNP@PUF) is proposed. Due to the passive heat barrier of GNP sheets, the resulting sponge exhibits excellent flame retardancy by reducing the critical fire retardancy metrics, that is, peak heat release rate, total heat release, and total smoke release by 72%, 50%, and 81%, respectively. In addition, GNP@PUF can function as a piezoresistive sensor and electromagnetic interference (EMI)‐shielding material. As a piezoresistive sensor, it exhibits a wide‐compressive pressure (2.4–112 kPa)/strain (5–70%) range and ultra‐fast response/relaxation time (48/35 ms), wide‐stretching strain (5–100%) range, and it can detect minute human motions by being attached to different parts of the human body. Meanwhile, the composite foam displays good absorption‐dominant EMI shielding performance (≈38 dB), possibly due to conductive dissipation and multiple reflections/scattering of EM waves inside the 3D conductive graphene network. This study provides a simple coating technique for developing multifunctional lightweight foam materials.

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Solvent-cast direct-writing as a fabrication strategy for radiopaque stents

Cited by 16 publications

References 55 publications

A 3D-Printed Graphene BioFuse Implant for Postsurgical Adjuvant Therapy of Cancer: Proof of Concept in 2D- and 3D-Spheroid Tumor Models

A 3D-Printed Graphene BioFuse Implant for Postsurgical Adjuvant Therapy of Cancer: Proof of Concept in 2D- and 3D-Spheroid Tumor Models

Functionalization of 3D printed polymeric bioresorbable stents with a dual cell-adhesive peptidic platform combining RGDS and YIGSR sequences

Graphene Nanoplatelet Exoskeleton on Polyurethane Foam to Produce Flame‐Retardant, Piezoresistive, and Electromagnetic Interference Shielding Surfaces

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