Solvent Acts as the Referee in a Match‐Up Between Charged and Preorganized Receptors
Nabarupa Bhattacharjee,
Xinfeng Gao,
Akash Nathani
et al.
Abstract:The prevalence of cation‐anion contacts in biomolecular recognition under aqueous conditions suggests that ionic interactions should dominate the binding of anions in solvents across both high and low polarities. Investigations of this idea using titrations in low polarity solvents are impaired by interferences from ion pairing that prevent a clear picture of binding. To address this limitation and test the impact of ion‐ion interactions across multiple solvents, we quantified chloride binding to a cationic re… Show more
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