Solvatochromism of antiinflammatory drug – naproxen sodium

Miotke, Marta M.; Józefowicz, Marek

doi:10.1016/j.molliq.2016.12.094

Cited by 28 publications

(13 citation statements)

References 21 publications

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“…As was shown in our previous paper [25], the shape and the position of the fluorescence excitation spectrum of NAP dissolved in different solvents is quite similar to the absorption one. Furthermore, the long-wavelength fluorescence excitation and fluorescence bands of NAP show an approximate mirror symmetry (see insert in fig.…”

Section: Steady-state Spectroscopic Measurementssupporting

confidence: 79%

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Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

et al. 2017

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Abstract. Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing. The presence of nanoparticles significantly improves the swelling. On the other hand, their presence hinders drug diffusion from polymer matrix and consequently causes delay of the drug release. The kinetics of swelling and release were carefully analyzed using the Korsmeyer-Peppas and the modified Hopfenberg models. The models were fitted to precise experimental data allowing accurate quantitative and qualitative analysis. We observed that 0.5% admixture of nanoparticles (Cloisite 30B) is the best concentration for hydrogel swelling properties. The release process was studied using fluorescence excitation spectra of NAP. Furthermore, we studied swelling hysteresis; polymer chains have not been destroyed after the swelling and part of swelled solution with active substances which remained absorbed in the polymer matrix after the drying process. We have found that the amount of solution with NAP remained in the nanocomposite matrix is greater than in pure hydrogel, as a consequence of NAP-OMMT interactions (nanosize effect).

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Section: Steady-state Spectroscopic Measurementssupporting

confidence: 79%

“…It was shown in our previous paper [25] that the shape and the position of the fluorescence excitation spectrum is quite similar to the absorption spectrum. The observed behavior indicates the existence of the same spatial conformations of NAP in the ground and excited states, which leads to estimate the amount of NAP molecules in the solution.…”

Section: Methodssupporting

confidence: 56%

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

et al. 2017

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“…The investigation of the photophysics of drugs or the photoreactive paths that might be activated upon photon absorption is crucial for identifying photoinitiated side effects, as well as in the design of novel and improved drugs. In the literature, there are a few experimental and computational studies on the photophysics of NSAIDs, most often based on steady state results [3,4,5,6,7,8,9,10,11,12,13,14], or on quantum chemical calculations on the energetics of their excited states, mainly at DFT/TD-DFT level of theory [2,15,16,17,18]. However, investigations of the excited state dynamics of these molecules are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Excited state dynamics of some nonsteroidal anti-inflammatory drugs: A surface-hopping investigation

Aguilera-Porta

Corral

Munoz-Muriedas

et al. 2019

Computational and Theoretical Chemistry

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Here we present a computational investigation of the excited state dynamics of 5 different active medical substances (aspirin, ibuprofen, carprofen, suprofen, indomethacin) which belong to the family of nonsteroidal anti-inflammatory drugs (NSAIDs). The nonadiabatic dynamics simulations were performed using the surface hopping method, with electronic energies and couplings evaluated on the fly in a semiempirical framework. For aspirin, the solvent decay dynamics was also considered by inserting it in a cluster of water molecules, following a QM/MM scheme. A quite diverse behavior was observed for the systems considered, going from fast deactivation to the S 0 (aspirin and ibuprofen), to ultrafast intersystem crossing to the triplet manifold (carprofen and suprofen), or to the generation of long lived S 1 states (indomethacin). To our knowledge, this is the first computational study of the photodynamics of these NSAIDs.

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“…An excellent hydrogel material can be designed after studying its behavior in contact with various environments and active substances. Taking into account above, the influence of non-specific and specific solute-solvent interactions on the investigated drug in different environments was presented in our previous studies [24].…”

Section: Introductionmentioning

confidence: 99%

Transport of paracetamol in swellable and relaxing polyurethane nanocomposite hydrogels

et al. 2019

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Polyurethane hydrogels are potentially attractive materials for biomedical applications. They are able to absorb large amount of water, biological fluids or active substances, and thus, they have potential to be used as absorbents or wound-healing dressings. They are also used for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. The presence of organofillized montmorillonite (Cloisite® 30B) in polyurethane nanocomposite hydrogels remarkably improves the swelling capability, but on the other hand slows down the release process of an active substance from the matrix. The swelling of paracetamol solution by the nanocomposite matrix and the release process of this active substance from the hydrogel were investigated using gravimetric analysis and spectroscopic method. The kinetics of both these processes were accurately analyzed by the use of Korsmeyer-Peppas and modified Hopfenberg and Weibull models. In the present paper, three different nanocomposite systems with various amounts of Cloisite® 30B were studied. The results of these studies confirm beneficial impact of the nanosize effect on the drug diffusion processes in polyurethane nanocomposite hydrogels.

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Solvatochromism of antiinflammatory drug – naproxen sodium

Cited by 28 publications

References 21 publications

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

Excited state dynamics of some nonsteroidal anti-inflammatory drugs: A surface-hopping investigation

Transport of paracetamol in swellable and relaxing polyurethane nanocomposite hydrogels

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