Solvation behavior of some nucleic acid bases and nucleosides in water and in aqueous guanidine hydrochloride solutions: Viscometric, calorimetric and spectroscopic approach

Banipal, Tarlok S.; Kaur, Navalpreet; Banipal, Parampaul K.

doi:10.1016/j.jct.2015.11.029

Cited by 13 publications

(25 citation statements)

References 45 publications

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“…The hyperchromic shift in the absorption spectra of CFX in GLY and ILU exhibits the significance of hydrophilic–hydrophilic/ionic interactions among them. In the case of CFX/ILU system, the blue shift in wavelength of CFX is due to a greater extent of interactions than CFX/GLY system. , These results are in concordance with our volumetric results.…”

Section: Resultssupporting

confidence: 91%

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Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 10⁵ Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies

et al. 2019

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Like the drug–salt interactions, drug–amino acid interaction in the aqueous medium is dependent upon different physiological events occurring in the body. In this context, investigations on the interactions of ciprofloxacin hydrochloride (CFX) being a second-generation antibiotic with both nonessential amino acid and essential amino acid have been done. The physicochemical properties like apparent molar volume (V 2,ϕ) and apparent molar isentropic compression (K s,2,ϕ) of drug, CFX in water and in the presence of glycine (GLY), and l-isoleucine (ILU) at m B (molality of GLY or ILU) = 10, 20, 35, 50, and 75 mmol·kg–1 have been determined over the temperature range of 288.15–323.15 K and at p = 1 × 105 Pa. These data have further been used to calculate different parameters, which help to obtain valuable information corresponding to the distinct kinds of interactions present in the ternary systems. The volumes and compressibility studies have shown that the predominant interactions are hydrophilic–hydrophilic and hydrophilic–ionic in the studied systems. It may be postulated that the effect of CFX prevails through the hydrophilic groups of the constituents of proteins. Dehydration behavior of drug is also observed using hydration number and calorimetry at higher m B values. Both hyperchromic and hypsochromic changes have been observed from the absorption spectra for the CFX/ILU system.

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Section: Resultssupporting

confidence: 91%

“…In the case of CFX/ILU system, the blue shift in wavelength of CFX is due to a greater extent of interactions than CFX/GLY system. 34,35 These results are in concordance with our volumetric results. ■ ASSOCIATED CONTENT * S Supporting Information…”

Section: Uv−vis Spectroscopysupporting

confidence: 92%

Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 10⁵ Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies

et al. 2019

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“…In fact, the contribution of three-body and higher order interactions is small compared with that of two-body interactions. Besides, the McMillan–Mayer’s theory assumes higher order coefficients also have the contribution from h 2 ; therefore it is difficult to interpret h 3 and h 4 …”

Section: Resultsmentioning

confidence: 99%

“…Besides, the McMillan−Mayer's theory assumes higher order coefficients also have the contribution from h 2 ; therefore it is difficult to interpret h 3 and h 4 . 43 3.2. Volumetric Properties.…”

Section: Resultsmentioning

confidence: 99%

Thermodynamic Difference between Protocatechualdehyde and p-Hydroxybenzaldehyde in Aqueous Sodium Chloride Solutions

Xie

Liu

et al. 2017

J. Chem. Eng. Data

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The enthalpies of dilution of protocatechualdehyde and p-hydroxybenzaldehyde in the aqueous sodium chloride solutions were measured by using a mixing-flow microcalorimeter at 298.15 K. Densities of the ternary homogeneous systems at different temperatures (293.15, 298.15, 303.15, 308.15, and 313.15 K) were also measured with a quartz vibrating-tube densimeter. The homogeneous enthalpic interaction coefficients (h 2, h 3, and h 4) were calculated according to the excess enthalpy concept based on the calorimetric data. The apparent molar volumes (V ϕ) and standard partial molar volumes (V ϕ 0) of the investigated system were computed from their density data. The variation trends in h 2 and V ϕ 0 with increasing salt molality were obtained and discussed in terms of the (solute + solute) and (solute + solvent) interactions. The experimental results showed that the molecular structures of protocatechualdehyde and p-hydroxybenzaldehyde, especially the number of hydroxyl groups, have evident influence on their thermodynamic properties. The thermodynamic data obtained in this work may be helpful for exploring the structure–function relationship of protocatechualdehyde and p-hydroxybenzaldehyde.

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“…The viscosity, η, of the solution increases with the molality of the solutes, m A and m B , but decreases with increasing temperature (Table S7). The η values for the studied solutes in an aqueous medium have been compared to those in the literature (Figure S7), which shows good agreement. Moreover, the viscosity data for uracil are in line with reported data, but there are slight deviations in the case of thymine.…”

Section: Resultsmentioning

confidence: 64%

Elucidation of Interactions between Ciprofloxacin Hydrochloride Monohydrate and Constituents of Nucleic Acids in Aqueous Solutions at Different Temperatures

et al. 2022

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The interaction of drugs with nucleic acids is one of the most essential parts of biological research in the drug discovery and pharmaceutical development processes. Furthermore, physicochemical studies of the solution behavior of such systems are extremely desirable for elucidating the various interactions in aqueous solutions. Therefore, in this context, measurements of the density (ρ), speed of sound (u), viscosity (η), and enthalpy of dilution (q) for uracil, thymine, uridine, and thymidine in water and in aqueous solutions of ciprofloxacin hydrochloride monohydrate (Cfx) at m B (molality of Cfx in water) = (5, 10, 15, 20, 25) mmol·kg–1 across the temperature range of T = (288.15 to 318.15) K and at p = 1 × 105 Pa have been performed. Furthermore, these data have been utilized to evaluate partial molar volumes, partial molar isentropic compressions, viscosity B coefficients, standard molar enthalpies of dilution, and their corresponding transfer parameters (Δtr V 2,Φ 0, Δtr K s,2,Φ 0, Δtr B, and ΔtrΔdil H°). These properties have been used to elucidate the presence of solute–solvent interactions. The solute–Cfx interactions are exothermic in nature, according to calorimetry studies. Furthermore, the UV–visible studies show that the interactions between the pyrimidine-based molecules and drug result in a shift in wavelength (λ) as well as a change in absorption.

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Solvation behavior of some nucleic acid bases and nucleosides in water and in aqueous guanidine hydrochloride solutions: Viscometric, calorimetric and spectroscopic approach

Cited by 13 publications

References 45 publications

Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 10⁵ Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies

Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 10⁵ Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies

Thermodynamic Difference between Protocatechualdehyde and p-Hydroxybenzaldehyde in Aqueous Sodium Chloride Solutions

Elucidation of Interactions between Ciprofloxacin Hydrochloride Monohydrate and Constituents of Nucleic Acids in Aqueous Solutions at Different Temperatures

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Solvation behavior of some nucleic acid bases and nucleosides in water and in aqueous guanidine hydrochloride solutions: Viscometric, calorimetric and spectroscopic approach

Cited by 13 publications

References 45 publications

Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 105 Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies

Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 105 Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies

Thermodynamic Difference between Protocatechualdehyde and p-Hydroxybenzaldehyde in Aqueous Sodium Chloride Solutions

Elucidation of Interactions between Ciprofloxacin Hydrochloride Monohydrate and Constituents of Nucleic Acids in Aqueous Solutions at Different Temperatures

Contact Info

Product

Resources

About

Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 10⁵ Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies

Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/l-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15–323.15 K and at Pressure p = 1 × 10⁵ Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies