Solvates of Dasatinib: Diversity and Isostructurality

On the kinetics of solvate formation through mechanochemistry

“…, for both single [15][16][17] and multicomponent solids (solvated co-crystals). 18,19 To the best of our knowledge, however, only two systematic studies with regard to the synthesis of solvates have been reported so far.…”

Rationalizing the Formation of Belinostat Solvates with Experimental Screening and Computational Predictions

“…PXRD patterns of Form I and eight new solvates are shown in Figure . It can be seen that the diffraction peak positions of solvates S Furan and S CP were very similar, which suggests the isostructurality − of the two solvates. However, the other six solvates exhibited different characteristic features from the PXRD patterns of the reported Form I and acetone solvate (Figure S1) of belinostat.…”

A solid solution of ethyl andd3-methyl 2-[(4-methylpyridin-2-yl)amino]-4-(pyridin-2-yl)thiazole-5-carboxylate

“…A search of the Cambridge Structural Database (CSD; Groom et al, 2016) in June 2020 via WebCSD (Thomas et al, 2010) revealed 15 metal-free crystal structures of 2-aminothiazoles with N-bonded heteroaromatic substituents containing a nitrogen atom in the 2-position, all of which adopt planar molecular conformations with intramolecular NÁ Á ÁS distances of 2.70 (4) Å (mean value), despite different crystal environments. These include structures of the tyrosine kinase inhibitor dasatinib and nine of its solvates (Roy et al, 2012;Sarceviča et al, 2016) as well as thiazovivin, a small-molecule tool for stem-cell research (Ries et al, 2013). The most related, the above-mentioned XOVJAV exhibits nearly planar N-HÁ Á ÁN hydrogen-bonded dimers in the crystal structure.…”