In this paper we study certain systems of mixed-type functional differential equations, from the point of view of the C 0 -semigroup theory. In general, this type of equations are not well-posed as initial value problems. But there are also cases where a unique differentiable solution exists. For these cases and in order to achieve our goal, we first rewrite the system as a classical Cauchy problem in a suitable Banach space. Second, we introduce the associated semigroup and its infinitesimal generator and prove important properties of these operators. As an application, we use the results to characterize the null controllability for those systems, where the control u is constrained to lie in a non-empty compact convex subset Ω of R n .