Solution Thermodynamics of Piroxicam in some Ethanol + Water Mixtures and Correlation with the Jouyban–Acree Model

Thermodynamic solubility of piroxicam in propylene glycol + water mixtures at 298.2-323.2 K: Data report and modeling

“…The minimum solubility of piroxicam was observed in aqueous solution (2.8×10 -5 M or 1.3×10 -7 mole fraction), which is in agreement with the literature value, 11 and the maximum solubility of piroxicam was observed in neat PG at 323.2 K (1.95×10 -4 M). As a clear result for the experimental solubility data, the addition of the cosolvent to the aqueous solutions and increasing the temperature led to solubility enhancement.…”

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

“…It has also been used in veterinary medicine to treat canines with transitional cell carcinoma of the urinary bladder. 181,182 There have been several publications 64,171,[183][184][185] involving the solubility of piroxicam in organic solvents. Most notably, Bustamante et al 171 measured the mole fraction solubility of piroxicam in 22 different organic solvents, including two saturated hydrocarbons (heptane and cyclohexane), one aromatic hydrocarbon (benzene), one alkyl alkanoate (ethyl ethanoate), one dialkyl ether (1,1′-oxybisethane) and one cyclic ether (1,4-dioxane), two chloroalkanes (trichloromethane and 1,2-dichloroethane) and one chlorinated aromatic hydrocarbon (chlorobenzene), seven alcohols (methanol, ethanol, 1-pentanol, 1-octanol, 1,2-ethanediol, 1,2-propanediol, and 1,2,3-propanetriol), one alkanone (propanone) and one aromatic ketone (acetophenone), and four miscellaneous organic solvents (ethanoic acid, propanoic acid, formamide, and N,Ndimethylformamide) at 298 K and atmospheric pressure.…”

Solubility and preferential solvation of sulfadiazine in methanol+water mixtures at several temperatures

“…sulfanilamide and sulfapyridine in propylene glycol (1) + water (2) mixtures [20,22]; as well as, with some analgesic drugs, i.e. ketoprofen in ethanol (1) + water (2) and propylene glycol (1) + water (2) mixtures [41,42], acetaminophen in PEG 400 (1) + water (2) mixtures [43], and piroxicam in ethanol (1) + water (2) mixtures [44].…”