“…The syn conformation found in the Z I and Z II forms of DNA (Wang et al, 1981) may serve as a more general model of the syn conformation in other contexts. Syn guanine bases were also found in the crystal structure of a dinucleotide bound to the enzyme barnase (Baudet and Janin, 1991), in DNA quadruplexes (Smith and Feigon, 1992;Kang et al, 1992), which may represent the structure of telomeric DNA, in mismatched base pairs (Cognet et al, 1991;Skelly et al, 1993;Roll et al, 1999), in stretched DNA (Lebrun and Lavery, 1996), and in some RNA tetraloops (Cheong et al, 1990). Therefore, interest in the syn conformation is not limited to Z DNA.…”