Solution Properties of Antitumor Sulfated Derivative of α-(1→3)-D-Glucan fromGanoderma lucidum

Antitumor Activities ofO-Sulfonated Derivatives of (1→3)-α-D-Glucan from DifferentLentinus edodes

“…3)--D-glucan, extracted from both the fruiting body of Canoderma lucidium and the curdlan exhibited significantly higher antitumor activity against Ehrlich ascites carcinoma (EAC). 17) It is indicated that O-sulfonation of the (1 ! 3)--D-glucan can improve its water solubility and antitumor activity.…”

“…It was very difficult completely to separate -and -glucans from the extract. 17) Compared with the 13 Figure 5 shows the SEC chromatograms of the native -glucans in 0. …”

Anti-Tumor Activities of the Antlered Form ofGanoderma lucidumin Allogeneic and Syngeneic Tumor-Bearing Mice

“…[10][11][12] Recently, active components, such as -D-glucans and triterpenoids, which exhibited anti-tumor effects, have been isolated from G. lucidum, and many experimental data in vitro and in vivo have been reported. [10][11][12][13][14][15][16][17][18][19] Anti-tumor activities of edible and medical mushrooms in vivo have been reported, 20) but Sarcoma 180 tumor-bearing mice have been used in many studies. Sarcoma 180 tumor is an allogeneic tumor, and so it cannot be denied that the anti-tumor mechanism in this model depends on the allograft rejection of the host animal.…”

Sulfated polysaccharide-protein complex sensitizes doxorubicin-induced apoptosis of breast cancer cells in vitro and in vivo

“…Sulfated polysaccharides have previously been reported to improve antitumor activity (35). In addition, SPPC was able to promote apoptosis and cell cycle arrest in human breast cancer cells, leading to loss of the MMP and activation of caspase-3 and caspase-9 (36).…”