Solution properties of an antidiabetic drug metformin hydrochloride in aqueous urea and thiourea solutions: A physicochemical study

Interaction Behavior of N-Lauroyl Sarcosine Sodium Salt (NLSS) and Benzethonium Chloride (BC) in Aqueous Human Serum Albumin (HSA) at Different Temperatures: A Volumetric and Acoustic Study

“…The values of V ϕ ° and S V along with standard errors for NLSS as well as BC in H 2 O and several aqueous concentrations of HSA are determined from the linear plots and are presented in Table . All of the V ϕ ° values are positive, which further increase with an increase in temperature as well as the concentration of HSA that occurs because of the domination of solute–solvent interactions …”

“…The partial molar expansivity can be computed utilizing the following relation , E ϕ ° = true( ∂ V ϕ ° ∂ T true) P = b + 2 c ( T − T r e f ) The E ϕ ° values for all of the investigated systems are given in Table S2. These values decrease on raising the temperature both in H 2 O and in several concentrations of HSA in water.…”

“…The values of apparent molar isentropic compressibility ( K ϕ,S ) of both NLSS and BC in water as well as in aqueous mixtures of HSA were obtained using the following equation , K ϕ , normalS = [ M k s ρ ] + [ ρ ° k s − ρ k S ° m ρ ρ ° ] where k s signifies the isentropic compressibility of the solution and k S ° represents the isentropic compressibility of the pure solvent, which are obtained using the following equations , k normals = 1 u 2 ρ k normalS ° = 1 u ° 2 ρ ° where u indicates the speed of sound of a given solution and u ° indicates the speed of sound in a given solvent. The u and K ϕ,S values are presented in Table .…”

“…This property provides effective information with respect to the solute–solvent interactions since the interactions among solute moieties are negligible at infinite dilution. The transfer values (Δ tr V φ ° ) of both surfactants from H 2 O to various concentrations of HSA were determined using the following relation , and are presented in Table The Δ tr V φ ° values are positive at each temperature, which upsurges on increasing the concentration of HSA in ternary systems. This can be described by a model called the cosphere overlap model, which states that the coinciding of hydration spheres of two charged moieties will result in an upsurge in volume, while the coinciding of hydration spheres of two uncharged moieties will result in a decline in volume. , The positive Δ tr V φ ° values in the current study clarify that hydrophilic–hydrophilic interactions lead over hydrophobic–hydrophobic interactions; however, as a whole, the coinciding of the hydration cospheres of surfactants (NLSS and BC) and HSA lowers the electrostriction of H 2 O via solute particles.…”

Synthesis, crystal structure, the Hirshfeld surface analysis, and antimicrobial activity of a three-dimensional Cu(II) complex with N-substituted biguanide

“…The free drug of MH has two different polymorphs, both of which have monoclinic structures: stable form I and metastable form II. 17,18 The structure of MH indicates that it can coordinate with cations or anions. Herein, we are concerned with the attractive properties of MH coordinated with metal ions and the new promising opportunities they may bring in the development of metal–drug complexes.…”