Solution processable polyamines via click chemistry for water purification

Goud, Vanga Devendar; Dsouza, Roshan F.; Valiyaveettil, Suresh

doi:10.1039/c5ra04155d

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Examples are vascular grafts and hydrogels for intraocular lenses, 13,14 nanocomposites for water purification, and self-repairing and fire-retardant polymers with improved resistance to mechanical and thermal stress. 15,16 The biomaterials produced have displayed improved performance both in vitro and in vivo . An example is the fabrication of vascular scaffolds based on a poly-1,8-azide-based octanediol citrate elastomer (POC-azide scaffolds), which enabled facile bioconjugation of heat-labile biomolecules via copper-free click reaction in aqueous environment at room temperature.…”

Section: Introductionmentioning

confidence: 99%

An improved synthesis of a cyclopropene-based molecule for the fabrication of bioengineered tissues via copper-free click chemistry

Meloni

Barton

Kaski

et al. 2019

Journal of Applied Biomaterials & Functional Materials

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Background: Since its introduction in the field of biological imaging, the use of copper-free click chemistry has been extended to produce improved materials for vascular surgery, ophthalmology, environmental, and automotive applications. This wide applicability suggests that larger quantities of the chemical reagents for copper-free click chemistry will be required in the future. However, the large-scale synthesis of such chemicals has been barely investigated. A possible reason is the shortage of reliable synthetic protocols to obtain large quantities of these building blocks. We therefore present in this paper an improved synthetic protocol to obtain a cyclopropene-based carbonate, a key building block for the well-known copper-free click chemistry. Method: Our protocol builds upon an already available method to obtain a cyclopropene-based carbonate. When scaled up, several parameters of this method were changed in order to obtain an improved yield. First, the use of lower temperatures and slower addition rates of the chemicals avoided the formation of detrimental hotspots in the reaction system. Second, the use of less hygroscopic solvents minimized the decomposition of the cyclopropene carbonate. Finally, chromatographic purifications were minimized and improved by using deactivated silica. Results: We obtained the compound (2-methylcycloprop-2-en-1-yl)methyl (4-nitrophenyl) carbonate, a key building block for copper-free click chemistry, in an unprecedented 60% overall yield on a six-gram scale. Conclusions: Our improved synthetic protocol demonstrates the potential of large-scale production of improved materials using click chemistry, with potential future applications in the fields of molecular imaging, vascular surgery, ophthalmology, and theranostics.

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