Solution-phase parallel synthesis of 4,6-diaryl-pyrimidine-2-ylamines and 2-amino-5,5-disubstituted-3,5-dihydro-imidazol-4-ones via a rearrangement

Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones

“…The Econfiguration was confirmed by X-ray structure of (1p) and two more chalcones (1k, 1m) which were already reported. 38) Spectral data (IR, 1 H-NMR and MS) of all the newly synthesized chalcones were in full agreement with the proposed structures. Configuration of the double bond (1a-s, 2a-s) was confirmed by coupling constant in 1 H-NMR.…”

“…Chalcones are a,b-unsaturated ketones which constitute an important group of natural products that serve as precursors for the synthesis of various heterocyclic compounds like pyrimidines, imidazoles, 1) pyrazoles, 2) 2-pyrazolines 3,4) and flavonoids. 5,6) Chalcones, either natural or synthetic, are known to exhibit various biological activities such as anti-inflammatory, 7,8) antifungal, [9][10][11][12] antioxidant, [13][14][15][16] antimalarial, [17][18][19][20] antituberculosis, 21) analgesic, 22) anti-human immunodeficiency virus (HIV) 23) and antitumor activities.…”

2-Amino-6-(3,4-ethylenedioxythiophen-2-yl)-4-(2-thienyl)-pyrimidine: Synthesis and properties

“…The synthetic procedure was based on a convenient approach including initial preparation of 2-acetyl-3,4-ethylenedioxythiophene (II) [8] which was brought into condensation with thiophene-2-carbaldehyde in alkaline medium to obtain previously unknown chalcone III. Cyclization of the latter in the presence of guanidine sulfate in alkaline medium according to the procedure described in [17] gave dihydropyrimidine IV, which was oxidized in situ to target product V.The electrochemical behavior of compounds III and V was studied by cyclic voltammetry. The measurements were performed under similar conditions using acetonitrile as solvent and tetraethylammonium…”

Synthesis and calming activity of 2-amino-4-(4-β-d-allopyranoside-phenyl)-6-3(4)-substituted phenylpyrimidines

“…1-Substituted N-methyl-series derivatives [4,5], benzimidazole derivatives [6,7], and oxadiazoline and isoxazole derivatives [8,9] were obtained by the Mannich reaction, condensation reaction, and 1,3-dipolar cycloaddition reaction, respectively. Because pyrimidines have the basic nucleus in nucleic acids and have been associated with a number of biological activities [10][11][12], the pyrimidine ring was introduced into the structure of helicid in order to further improve the biological activities of helicid.Styryl-acetophenone, guanidine hydrochloride, and KOH can be directly generate the pyrimidine ring [13,14]. In this paper, the extension of the formyl conjugate carbon chain was performed by the Shmidt-Claisen reaction to get D,E-unsaturated carbonyl derivatives 1a-1h.…”

“…Styryl-acetophenone, guanidine hydrochloride, and KOH can be directly generate the pyrimidine ring [13,14]. In this paper, the extension of the formyl conjugate carbon chain was performed by the Shmidt-Claisen reaction to get D,E-unsaturated carbonyl derivatives 1a-1h.…”