Solution Phase Gold Nanorings on a Viral Protein Template

Zahr, Omar; Blum, Amy Szuchmacher

doi:10.1021/nl203368v

Cited by 69 publications

(79 citation statements)

References 40 publications

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“…The simplest such architecture comprises two gold (Au) NPs connected by a molecular linker, (Busson et al 2011;Wang et al 2013) though the presence of the linker in the hot spots between the NPs can hinder analyte access. Fortunately, certain high symmetry biomolecules, such as DNA (Barrow et al 2012;Zhao et al 2013b) and viral protein capsids (or genetically engineered derivatives thereof), (Zahr and Blum 2012); (Spano et al 2007) possess sufficiently stable 3D structures bearing surface functional groups capable of binding NPs at precise locations with fixed NP-NP separation distances on their surfaces. NP binding at these sites leads to nanoscale noble metal NP-biomolecule composites in which hindrance of analyte access to the hot spots is minimized.…”

Section: Introductionmentioning

confidence: 99%

A virus-based nanoplasmonic structure as a surface-enhanced Raman biosensor

Lebedev

Griva

Dressick

et al. 2016

Biosensors and Bioelectronics

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Fabrication of nanoscale structures with localized surface plasmons allows for substantial increase in sensitivity of chem/bio sensors. The main challenge for realizing complex nanoplasmonic structures in solution is the high level of precision required at the nanoscale to position metal nanoparticles in 3D. In this study, we report a virus-like particle (VLP) for building a 3D plasmonic nanostructure in solution in which gold nanoparticles are precisely positioned on the VLP by directed self-assembly techniques. These structures allow for concentration of electromagnetic fields in the desired locations between the gold nanoparticles or "hot spots". We measure the efficiency of the optical field spatial concentration for the first time, which results in a ten-fold enhancement of the capsid Raman peaks. Our experimental results agree with our 3D finite element simulations. Furthermore, we demonstrate as a proof-of-principle that the plasmonic nanostructures can be utilized in DNA detection down to 0.25 ng/μl (lowest concentration tested), while the protein peaks from the interior of the nanoplasmonic structures, potentially, can serve as an internal tracer for the biosensors.

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Section: Introductionmentioning

confidence: 99%

A virus-based nanoplasmonic structure as a surface-enhanced Raman biosensor

Lebedev

Griva

Dressick

et al. 2016

Biosensors and Bioelectronics

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“…Template-based or directed assemblies result in structures dictated by template size and shape. Both soft templates such as polymers [5], DNA [6], and proteins [7], including virus coat proteins [8–9] as well as rigid templates such as carbon nanotubes [10] have been extensively implemented and programmed for desired assemblies. In addition, assisted organization and alignment of nanoparticles via external directing magnetic [11] and electric [12] fields have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Tunable longitudinal modes in extended silver nanoparticle assemblies

Bayram

Lindfors

Blum

2016

Beilstein J. Nanotechnol.

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SummaryNanostructured materials with tunable properties are of great interest for a wide range of applications. The self-assembly of simple nanoparticle building blocks could provide an inexpensive means to achieve this goal. Here, we generate extended anisotropic silver nanoparticle assemblies in solution using controlled amounts of one of three inexpensive, widely available, and environmentally benign short ditopic ligands: cysteamine, dithiothreitol and cysteine in aqueous solution. The self-assembly of our extended structures is enforced by hydrogen bonding. Varying the ligand concentration modulates the extent and density of these unprecedented anisotropic structures. Our results show a correlation between the chain nature of the assembly and the generation of spectral anisotropy. Deuterating the ligand further enhances the anisotropic signal by triggering more compact aggregates and reveals the importance of solvent interactions in assembly size and morphology. Spectral and morphological evolutions of the AgNPs assemblies are followed via UV–visible spectroscopy and transmission electron microscopy (TEM). Spectroscopic measurements are compared to calculations of the absorption spectra of randomly assembled silver chains and aggregates based on the discrete dipole approximation. The models support the experimental findings and reveal the importance of aggregate size and shape as well as particle polarizability in the plasmon coupling between nanoparticles.

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“…Ligand-stabilized Au NPs have been assembled to form ring structures through electrostatic interactions with a disk-shaped viral protein template. 21 However, the ring assembly of NPs in liquid phase without obvious anisotropic interactions or template is generally a challenging task.…”

Section: Introductionmentioning

confidence: 99%

Ring assembly of silica nanospheres mediated by amphiphilic block copolymers with oxyethylene moieties

Zhou

Oda

Shimojima

et al. 2014

Polym J

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Silica nanospheres (SNSs) of ca. 15 nm in diameter assemble into nanoring structures with the aid of amphiphilic block copolymers containing the oxyethylene side chains poly[(2-ethoxyethyl vinyl ether)-block-(2-methoxyethyl vinyl ether)] [poly(EOVEb-MOVE)]. Cryo-transmission electron microscope observation confirms that the ring assembly of SNSs occurs in the liquid phase. The SNSs favorably assemble into ring-like nanostructures in the presence of 1-2 wt% EOVE 100 -b-MOVE 310 at pH~7.8 and 45°C. Irregular aggregates of SNSs form at 60°C, most likely because of the hydrophobic collapse of the thermoresponsive block copolymer. A series of poly(EOVE-b-MOVE) with varying block lengths successfully induce the ring assembly of SNSs, whereas a random copolymer fails, indicating that the polymer's molecular structure critically affects the assembly mode of SNSs. Interestingly, SNSs of a larger size (ca. 30 nm) assemble one-dimensionally into chain-like nanostructures in the presence of EOVE 100 -b-MOVE 310 .

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Solution Phase Gold Nanorings on a Viral Protein Template

Cited by 69 publications

References 40 publications

A virus-based nanoplasmonic structure as a surface-enhanced Raman biosensor

A virus-based nanoplasmonic structure as a surface-enhanced Raman biosensor

Tunable longitudinal modes in extended silver nanoparticle assemblies

Ring assembly of silica nanospheres mediated by amphiphilic block copolymers with oxyethylene moieties

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