Solution-mediated phase transformation of uric acid dihydrate

Presores, Janeth B.; Swift, Jennifer A.

doi:10.1039/c4ce00574k

Cited by 18 publications

(26 citation statements)

References 33 publications

(19 reference statements)

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“…It has previously been shown that UAD transforms to UA in solution via a dissolution–recrystallization mechanism. The kinetics of this process have been reported elsewhere . This frequently involves the epitaxial nucleation and growth of UA on dissolving UAD surfaces.…”

Section: Resultsmentioning

confidence: 97%

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Urochrome Pigment in Uric Acid Crystals

et al. 2016

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Renal stones are heterogeneous composites of numerous microscopic crystals (e.g., calcium oxalate, calcium phosphate, uric acid, etc.) and 2–3 wt % amorphous organic “matrix”. Uric acid kidney stones are often red–orange–brown in color, though uric acid crystals are colorless. The stone color originates from a variety of components in the matrix, some of which are a broad range of urinary pigments or urochrome. Herein, we report the first definitive structure of one of these pigments, urorosein, and its ability to form intracrystalline inclusions in single crystals of both anhydrous uric acid and uric acid dihydrate. The preferred orientation of the included urorosein molecules in the uric acid crystals was determined through polarized light microspectroscopy. On the basis of these results, it seems likely that other urochrome pigments can locate in both intercrystalline and intracrystalline spaces in urinary precipitates. This expands the conventional picture of where “matrix” resides in these composite materials.

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Section: Resultsmentioning

confidence: 97%

“…The kinetics of this process have been reported elsewhere. 68 This frequently involves the epitaxial nucleation and growth of UA on dissolving UAD surfaces. On only one occasion was a single UA-Ur crystal with an hourglass inclusion observed.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Urochrome Pigment in Uric Acid Crystals

et al. 2016

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“…[ 4,13 ] In this regard, the acidic pH reached with our methodology (pH of 4.1) to induce the crystallization phenomenon promoted the synthesis of anhydrous uric acid and/or uric acid dihydrated crystals, [ 10 ] making unlikely the synthesis of monosodium urate crystals, since these crystals grow at a neutral pH. [ 14 ] Considering the XRD pattern and previous work, [ 15 ] the crystals obtained with this method were anhydrous uric acid crystals.…”

Section: Discussionmentioning

confidence: 96%

“…The images with SEM showed that the AUA crystals are arranged in stacked layer sheets with an orthorhombic‐like shape, in agreement with a previous description for the same type of crystals. [ 10,15,18 ] Subsequent accumulation of those layers generated a tridimensional pattern, a typical feature of crystals that grow mainly in a longitudinal manner. [ 4,14 ] In this sense, the crystals showed different thickness across the crystal structure, probably because of the subsequent and stochastic structuration of the acid uric sheets, each of them contributing at least to the 600 nm of thickness.…”

Section: Discussionmentioning

confidence: 99%

Growth Kinetics Analysis and Morphological Characterization by Electron Microscopy of Anhydrous Uric Acid Crystals

Chávez‐Reyes¹,

Hernández‐Cuellar²,

González-Ponce

et al. 2021

Crystal Research and Technology

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In vitro synthesis of uric acid crystals provides an important source to study the process of crystal formation and to understand how the deposition of these crystals induces disease; nevertheless, the described methodologies for the synthesis of uric acid crystals are time‐consuming, depend on the use of high volumes, and the time scale precludes the kinetics study of the crystal growth. In the present work, it is described a fast method for the synthesis of anhydrous uric acid (AUA) crystals using microvolumes, and the crystal growth kinetics is characterized by light field microscopy using nonlinear adjustment. In addition, a crystal morphological characterization by scanning electron microscopy and X‐ray diffraction is made, disclosing that the AUA crystals are arranged in stacked layer sheets with an orthorhombic‐like shape. These results help to understand the phenomenon of crystallization of uric acid, which is a trigger event on the development of uric acid nephrolithiasis.

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“…Crystal growth depends on the delicate balance between a variety of kinetic and thermodynamic factors . It is of high importance to adopt a control strategy of polymorph formation to produce the desired form , . Furthermore, it is essential to understand the possible transformations in a polymorphic system and the transformation mechanism under different conditions .…”

Section: Introductionmentioning

confidence: 99%

Crystal Structures and Phase Behavior of Sulfadiazine and a Method for the Preparation of Aggregates with Good Performance

Chen

et al. 2018

Chem Eng & Technol

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The solvate and the solvent-free form of sulfadiazine (SD) were investigated. SD was found to exist in one solvent-free form and the N-methylpyrrolidone (NMP) solvate form. The NMP solvate was shown to be a channel-type compound. The intrinsic properties of the solvents were used to evaluate the effects of solubility on the phase transformation of SD and the NMP solvate. The SD phase could transform to the NMP solvate by NMP-mediated phase transformation, which was governed by crystallization of the NMP solvate. The crystalline NMP solvate could transform to the solvent-free solid state through solid-solid transformation upon heating or water penetration-mediated phase transformation. The rate of this water penetration-mediated phase transformation of the NMP solvate to SD was unusually fast. It can be used to obtain SD aggregates of well-defined shape and good powder properties.

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Solution-mediated phase transformation of uric acid dihydrate

Abstract: Various crystalline phases of uric acid are frequently identified components of human kidney stones, including anhydrous uric acid (UA) and uric acid dihydrate (UAD).

Cited by 18 publications

References 33 publications

Urochrome Pigment in Uric Acid Crystals

Urochrome Pigment in Uric Acid Crystals

Growth Kinetics Analysis and Morphological Characterization by Electron Microscopy of Anhydrous Uric Acid Crystals

Crystal Structures and Phase Behavior of Sulfadiazine and a Method for the Preparation of Aggregates with Good Performance

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