Solution equilibria and stabilities of binary and ternary Nickel(II) complexes with picolinic acid and small blood serum bioligands

Pérez, Alejandro; Hernández, Lino; Carpio, Edgar Del; Lubes, Vito

doi:10.1016/j.molliq.2014.02.038

Cited by 14 publications

(3 citation statements)

References 10 publications

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“…In Table , the p K a values of the ligands studied in this work are shown. Good agreement is observed between the values determined in this work and the values reported in the literature − and stability constants databases. , …”

Section: Resultssupporting

confidence: 87%

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Chacón,

Araujo,

Hernández Mazzocchin

et al. 2023

J. Chem. Eng. Data

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This study reports on the determination of stability constants for ternary cobalt(II) complexes using primary ligands, pyridine carboxylic acids (picolinic (HPic) and dipicolinic (H2Dipic) acids), along with secondary ligands: lactic acid (HLac, HL), oxalic acid (H2Ox, H2L), citric acid (H3Cit, H3L), and phosphoric acid (H3PO4, H3L). Potentiometric data for binary cobalt(II) bioligand complexes and ternary cobalt(II) pyridine carboxylic acid and bioligand complexes were analyzed using the computational program LETAGROP. The experiments were conducted in an ionic medium of 1.0 mol dm–3 NaNO3 at 25 °C. Species distribution diagrams were generated, and relative stability parameters Δlog10 K, log10 X, and % R.S. were calculated. These findings may have important implications for the design of new cobalt(II) complexes for various applications.

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Section: Resultssupporting

confidence: 87%

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Chacón,

Araujo,

Hernández Mazzocchin

et al. 2023

J. Chem. Eng. Data

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“…Equilibria corresponding to the formation of the hydroxo complexes of Ni(II) and the stability constants of the binary complexes were previously determined [8][9][10].…”

Section: Methodsmentioning

confidence: 99%

Ternary complex formation between Nickel(II)–Dipicolinic acid with small blood serum bioligands

Ramirez

Martínez

Araujo

et al. 2016

Journal of Molecular Liquids

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“…Besides its wide variety of physiological properties, picolinic acid is also an industrially significant compound, used as an active substance in a number of dietary supplements [33,34]. Picolinic acid and its derivatives are present in the literature as multidentate ligands whose coordination modes rely on two different ligator atoms [35,36]. Some Pt(II) [37] as well as Ru(II) complexes [38,39] with this type of ligand were synthesized and proved to be active against various cell lines.…”

Section: Introductionmentioning

confidence: 99%

Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

Baroud

Mihajlović-Lalić

Gligorijević

et al. 2017

Journal of Coordination Chemistry

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Complexes 1-4, [Ru(L)(bpy) 2 ]PF 6 , where bpy = 2,2′-bipyridine; L = 3-methylpyridine-2carboxylic acid (L1), 6-methylpyridine-2-carboxylic acid (L2), 5-bromopyridine-2-carboxylic acid (L3) and 6-bromopyridine-2-carboxylic acid (L4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72 h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 ± 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200 μM. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthioninesulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction.

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Solution equilibria and stabilities of binary and ternary Nickel(II) complexes with picolinic acid and small blood serum bioligands

Cited by 14 publications

References 10 publications

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Ternary complex formation between Nickel(II)–Dipicolinic acid with small blood serum bioligands

Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

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