Solution Behaviour of Rivanol in Micellar Environments

Göktürk, Sinem; Talman, R. Yeşim; Erdinç, Neşe; Tunçay, Melda

doi:10.1080/00387010600803599

Cited by 10 publications

(10 citation statements)

References 70 publications

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“…where concentrations are expressed in molar units. Binding constants of SMX and TMP to micelles were calculated using the Benesi–Hildebrand Equation (Benesi and Hildebrand, ) in the following modified form (Erdinc et al, ; Gokturk et al, ):

\frac{([], D) l}{A - A_{0}} = \frac{1}{normalΔ ε} + \frac{1}{K_{b} ([], C) ((), normalΔ ε)}

…”

Section: Methodsmentioning

confidence: 99%

“…In those studies, it was reported that the spectral characteristics of drugs are significantly affected by the presence of surfactants (Banipal et al, ; Caetano and Tabak, ; Cudina et al, ; Enache and Volanschi, ; Erdinc et al, ; Gokturk et al, ; Qian et al, ; Rub et al, ). Those reports also confirmed that there are two types of interactions between drugs and surfactants depending on the chemical structure of both drugs and surfactants i.e., at concentrations below the CMC, a decrease in the absorbance with the appearance of a new band indicates the formation of a complex between drug and surfactant molecules, while above the CMC an increase in the absorption coefficient at high micelle concentrations indicates incorporation of drugs into micelles (Caetano and Tabak, ; Cudina et al, ; Enache and Volanschi, ; Erdinc et al, ; Gokturk et al, ). In this context, the binding constants of drugs to micelles can be quantitatively determined using the simple mathematical model known as the Benesi–Hildebrand equation based on the Beer–Lambert law valid in the high micelle concentration region (Benesi and Hildebrand, ).…”

Section: Introductionmentioning

confidence: 99%

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Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Göktürk

TAMER

2018

J Surfact & Detergents

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Absorption spectroscopy, conductivity, and surface tension measurements were carried out at 298 K to study the solubilization of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in Aerosol‐OT (AOT) micellar media. The binding constants of SMX and TMP to AOT micelles were determined by applying the Benesi–Hildebrand equation. A comparison of the binding constants indicates that the binding tendency of TMP with AOT micelles is higher than that of SMX. To better analyze the incorporation of drugs into anionic AOT micellar media, surface tension measurements were performed in the presence of SMX and TMP in aqueous media. The influence of TMP and SMX on the surface properties of AOT was determined using the Gibbs Adsorption Isotherm. Changes in the surface properties of AOT determined by surface tension measurements in the presence of drugs are in good agreement with the binding constants determined spectrophotometrically. Calculated surface parameters indicate higher incorporation of TMP with AOT than that of SMX. Comparison of the aqueous solubility of TMP and SMX with micellar media indicated solubility enhancements for both poorly soluble drugs. A special attempt was made to highlight simultaneous interactions of TMP and SMX with AOT using both surface tension and conductometric measurements that can be used to determine counterion‐binding parameters.

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\frac{([], D) l}{A - A_{0}} = \frac{1}{normalΔ ε} + \frac{1}{K_{b} ([], C) ((), normalΔ ε)}

…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Göktürk

TAMER

2018

J Surfact & Detergents

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“…The electrostatic interaction combined with the classical hydrophobic interactions act concurrently bringing out the largest changes as shown in previous studies [3][4][5][6]17,24,25 . Studies on the dyesurfactant interactions using conductometry have also been scarcely reported 9,18,26 .…”

Section: Introductionmentioning

confidence: 75%

“…Dyes can also be used in many ways for measuring critical micelle concentration (CMC) of surfactants known as dye-solubilization method. Thus the study of dye-surfactant interaction is important from the fundamental understanding point of view as well as industrial applications [1][2][3][4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

“…Among several known technique for investigating dye-surfactant interactions, the conductivity measurement and spectroscopy are simple and accessible methods for determining the degree of interaction dye and surfactant [2][3][4][5][6] . The sudden change in these measured quantities indicating a significant variation in the nature of the solution specie.…”

Section: Introductionmentioning

confidence: 99%

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Spectrophotometric and Conductometric Studies on the Interaction of Anionic Dye Eosin-Y with Cationic Micelles

Erdinç¹,

Göktürk²

2014

Analytical Chemistry Letters

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In this paper, spectrophotometric and conductometric methods were used to study the interaction phenomenon between oppositely charged anionic Eosin-Y and cationic surfactants; dodecyltrimethylammonium bromide, tetradecyltrimethylammonium bromide, cetyltrimethylammonium bromide, cetylpyridinium bromide and cetylpyridinium chloride. Conductivity measurements of surfactants were performed and the degree of micellar ionization was determined in the absence and presence of Eosin-Y. The ionization degree and counterion binding parameter obtained from conductivity data are used to evaluate the interaction mechanism of Eosin-Y in wide range of different hydrophobic cationic microenvironments as well. The absorption spectra were used to quantify the binding constants by means of Benesi-Hildebrand equation. Comparison of the binding degree of Eosin-Y to micelles indicates a direct correlation between binding constant and hydrophobicity. The micellar properties of cationic surfactants at levels below and above their CMCs in aqueous and in the presence of Eosin-Y were also studied using conductivity and spectrophotometry. It was observed that the CMC values of cationic surfactants decreased in the presence of Eosin-Y. The spectrophotometric behavior of Eosin-Y in water-EOH mixture of varying composition was also monitored in order to gain more information about the localization of Eosin-Y in cationic micelles.

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