Solution and Surface Properties of Metformin Hydrochloride in Aqueous Solution and Its Interaction with Amino Acids and Anionic Surfactant, Sodium Dodecyl Sulphate

Shakeel, Muhammad; Mehmood, Khalid; Siddiq, Muhammad

doi:10.1007/s40010-018-0587-2

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…Gibbs adsorption Equation is used to calculate its value from surface tension measurements for ionic surfactants. [ 5 ]

normalΓ = - ((), 1 / ((), RTy)) {(dγ / d \ln m)}_{T}

In this equation, T is absolute temperature; R is general gas constant while y is estimated by following relation.

y = 1 + ([], m / ((), m + m_{s}))

…”

Section: Resultsmentioning

confidence: 99%

“…[ 12 ] Moreover, ΔG° ads is found to be more negative than ΔG° m , which means that the adsorption of drug molecules at solution–air interface is more spontaneous than micellization and completes prior to it. [ 5,25 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 3,4 ] Moreover, such drug molecules, being amphiphilic in nature, may get accumulated in the form of aggregates (micelles) in human body if taken in concentration greater than definite value, which causes health problems by lowering the transport rate through the biomembranes. [ 5 ] That concentration of amphiphilic drug at which this aggregate formation is initiated is known as critical micelle concentration (CMC). [ 6,7 ] Thus, the idea of CMC of amphiphilic drug is very important in this regard.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, in literature viscometric and volumetric study, determination of CMC and related parameters and drug–surfactant interaction are reported separately, but we have combined all these studies for a single drug in a single paper, like our other publications on other drugs. [ 5,14,15 ] In these publications, metformin hydrochloride (Met HCl), sodium valproate (SV), and chlorpheniramine maleate (CPAM) in aqueous medium were studied. All these drugs showed hydrophobic interaction with water solvent.…”

Section: Introductionmentioning

confidence: 99%

“…All these drugs showed hydrophobic interaction with water solvent. [ 5,14,15 ] Molecules of CPAM become incorporated between the ionic heads of micelles of sodium dodecyl sulfate (SDS) [ 15 ] while those of Met HCl and SV showed interaction with surfactant by attachment on the surface of micelles of SDS and cetyltrimethylammonium bromide (CTAB), [ 5,14 ] respectively. In the present study, a different drug, that is, LP was used, and its viscometric, volumetric studies, and interaction with CTAB were carried out.…”

Section: Introductionmentioning

confidence: 99%

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Study of volumetric, viscometric, and aggregation properties of losartan potassium and its interaction with amino acids and cetyltrimethylammonium bromide in aqueous solution

Shakeel

Mahmood

2020

J of Physical Organic Chem

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This manuscript reports volumetric, viscometric, and aggregation properties of losartan potassium (LP) in aqueous medium and its interaction with a cationic surfactant (cetyltrimethylammonium bromide [CTAB]). Densities of drug solutions were used to calculate apparent molar volumes while constants of Jones–Dole equation were calculated from viscosity measurements. By measuring surface tension, refractive index, and electrical conductivity of drug solutions, critical micelle concentration (CMC) of drug was determined, and calculation of surface excess concentration, free energy change of adsorption, free energy change, entropy change, and enthalpy change of micellization was carried out. UV/Visible spectroscopic data were used to get an understanding about the interaction of drug with cationic surfactant (CTAB). This interaction gives an idea about the interaction of drug with biomembrane as micelles of surfactant are similar to membranes in structure. The data were also used to calculate different important parameters for drug–surfactant interaction such as partition coefficient and binding constant. Moreover, two amino acids (glycine and l‐tryptophan) were used in solutions of drug separately to change its CMC. The results from volumetric and viscometric studies showed that the presence of drug in solution resulted in more organization of solvent molecules due to hydrophobic interaction. From the values of ∆G°ads and ∆G°m, it was concluded that the adsorption of drug molecules at solution–air interface and formation of micelles occurred spontaneously. A strong drug‐surfactant (LP–CTAB) interaction was observed by the attachment of drug molecules onto micellar surface of surfactant. The presence of amino acids in the solution of drug caused a decrease in the CMC of LP.

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“…Gibbs adsorption Equation is used to calculate its value from surface tension measurements for ionic surfactants. [ 5 ]