“…This conclusion is consistent with previous findings that heme pocket structure is well preserved in isolated subunits, based on far-UV (69,70) and near-UV CD (69 -72) and homonuclear NMR studies of ferrous and ferric ␣Hb (47,55,56,73,74). None of these data provide any hints as to why free ␣Hb is more prone to oxidation and subsequent rapid loss of the heme moiety and aggregation.…”