Solute Transport, Energy Consumption, and Production in the Kidney

Sekine, Takashi; Miyazaki, Hiroyuki; Endou, Hitoshi

doi:10.1016/b978-012088488-9.50010-3

Cited by 3 publications

(4 citation statements)

References 294 publications

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“…On the other hand, mitochondrial ATP production in high energy demanding segments like the proximal tubule (PT) is principally sustained by β-oxidation of FA, like palmitate that represents ~25% of total FAs in plasma [ 26 ]. Likewise, proteomic and Western blot analysis of the remnant kidney in 5/6Nx rats shows a reduction in FA β-oxidation–related proteins on day 28 [ 22 ] and we recently reported in a model of kidney damage induced by folic acid, that the impairment in OXPHOS capacity and the decrease in β-oxidation favor the transition from AKI to CKD [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

Temporal Alterations in Mitochondrial β-Oxidation and Oxidative Stress Aggravate Chronic Kidney Disease Development in 5/6 Nephrectomy Induced Renal Damage

Aparicio-Trejo

Rojas-Morales

Avila-Rojas

et al. 2020

IJMS

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Five-sixths nephrectomy (5/6Nx) model is widely used for studying the mechanisms involved in chronic kidney disease (CKD) progression, a kidney pathology that has increased dramatically in recent years. Mitochondrial impairment is a key mechanism that aggravates CKD progression; however, the information on mitochondrial bioenergetics and redox alterations along a time course in a 5/6Nx model is still limited and in some cases contradictory. Therefore, we performed for the first time a time-course study of mitochondrial alterations by high-resolution respirometry in the 5/6Nx model. Our results show a decrease in mitochondrial β-oxidation at early times, as well as a permanent impairment in adenosine triphosphate (ATP) production in CI-linked respiration, a permanent oxidative state in mitochondria and decoupling of these organelles. These pathological alterations are linked to the early decrease in complex I and ATP synthase activities and to the further decrease in complex III activity. Therefore, our results may suggest that mitochondrial bioenergetics impairment is an early event in renal damage, whose persistence in time aggravates CKD development in the 5/6Nx model.

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Section: Resultsmentioning

confidence: 99%

Temporal Alterations in Mitochondrial β-Oxidation and Oxidative Stress Aggravate Chronic Kidney Disease Development in 5/6 Nephrectomy Induced Renal Damage

Aparicio-Trejo

Rojas-Morales

Avila-Rojas

et al. 2020

IJMS

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“…This pathology affects importantly the kidneys, 44,45 and growing evidence suggests that lipotoxicity, together with mitochondrial dysfunction, 38,39 are common pathologies in several types of CKD. In fact, ATP production in kidneys is predominantly sustained by FA β‐oxidation 39,46 . Tubular epithelial cells (TECs) are among the most energy‐demanding cells in the body; therefore they must produce ATP by FA β‐oxidation and have high FA uptake capacity.…”

Section: Mitochondrial Dysfunction In the Uuo Modelmentioning

confidence: 99%

“…In fact, ATP production in kidneys is predominantly sustained by FA β-oxidation. 39,46 Tubular epithelial cells (TECs) are among the most energy-demanding cells in the body; therefore they must produce ATP by FA β-oxidation and have high FA uptake capacity. However, in a pathological context, TECs are one of the main locations for lipid accumulation.…”

Section: Mitochondrial Bioenergetics and Metabolic Alterationsmentioning

confidence: 99%

Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction

et al. 2020

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Obstructive nephropathy favors the progression to chronic kidney disease (CKD), a severe health problem worldwide. The unilateral ureteral obstruction (UUO) model is used to study the development of fibrosis. Impairment of renal mitochondria plays a crucial role in several types of CKD and has been strongly related to fibrosis onset. Nevertheless, in the UUO model, the impairment of mitochondria, their relationship with endoplasmic reticulum (ER) stress induction and the participation of both to induce the fibrotic process remain unclear. In this review, we summarize the current information

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“…Fatty acid metabolism involves a balance between FA synthesis and degradation. In addition, the ATP production in the proximal tubule depends on fatty acid β-oxidation [ 30 , 31 ]. Thus, we evaluated the mitochondrial respiratory parameters related to β-oxidation.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

et al. 2022

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Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects. This work aimed to characterize CUR’s potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß-oxidation in the liver and kidney in 5/6Nx. Male Wistar rats were subjected to 5/6Nx and progressed by 4 weeks; meanwhile, CUR (120 mg/kg) was administered for weeks 5 to 8. Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver.

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Solute Transport, Energy Consumption, and Production in the Kidney

Cited by 3 publications

References 294 publications

Temporal Alterations in Mitochondrial β-Oxidation and Oxidative Stress Aggravate Chronic Kidney Disease Development in 5/6 Nephrectomy Induced Renal Damage

Temporal Alterations in Mitochondrial β-Oxidation and Oxidative Stress Aggravate Chronic Kidney Disease Development in 5/6 Nephrectomy Induced Renal Damage

Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction

Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

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