Solute–solvent interactions in normal-phase liquid chromatography: a linear free-energy relationships study

Oumada, Fadoua Z.; Rosés, Martı́; Bosch, Elisabeth; Abraham, Michael H.

doi:10.1016/s0003-2670(98)00787-9

Cited by 64 publications

(25 citation statements)

References 17 publications

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“…They reported that for ionic liquid stationary phases in gas chromatography, hydrogen bond basicity emanated from the ionic liquid anion [24]. The strong dependence upon mobile phase composition observed here for the a coefficient (Figure 2) is consistent with previous reports for normal phase LSER characterizations of bare silica phases [20,21]. In these previous reports of silica columns characterized with hexane/2-propanol mobile phases, the a coefficient decreases with an increase in the concentration of the polar component of the mobile phase and is attributed to increased adsorption of 2-propanol to the silica surface at high concentrations of 2-propanol in the mobile phase [21].…”

Section: 12supporting

confidence: 91%

“…Previously, it was reported, on a related SCIL phase under high organic mobile phase compositions, a similar positive s coefficient was attributed to desolvation of the immobilized anion/cation pair [2]. Both of these findings are in contrast to previous work, where the positive s term is seen to decrease for various polar phases [13] or remains insensitive for bare silica [21] with an increase in the polar component of the mobile phase; this may be an important distinction between the synthesized SCIL phases and commercially available phases.…”

Section: 11mentioning

confidence: 58%

“…While used extensively in gas chromatography and reversed phase HPLC [11,12], the application of the LSER method to normal phase HPLC [8,13,14,15,20,21] has been somewhat sparse, perhaps because of the more limited application range of normal phase HPLC relative to gas chromatography and reversed phase HPLC. Furthermore, because the retention mechanism of silica phases is based on adsorption, the LSER model, which is based on the cavity model of salvation [11], may not be entirely appropriate.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, because the retention mechanism of silica phases is based on adsorption, the LSER model, which is based on the cavity model of salvation [11], may not be entirely appropriate. Indeed, normal phase LSER studies on silica phases have shown reduced correlations [20,21,22] relative to reversed phase characterization. However, LSER has been somewhat successful at modeling normal phase retention on polar bonded phases [22].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships

Meter

Stuart

Carle

et al. 2008

Journal of Chromatography A

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Utilizing Linear Solvation Free Energy Relationship methodology, a novel pyridinium bromide surface confined ionic liquid (SCIL) stationary phase was characterized under normal phase High Performance Liquid Chromatographic conditions. A limited set of neutral aromatic probe solutes were utilized to rapidly assess the utility of the LSER model, using mobile phases of hexane modified with 2-propanol. The excellent correlation of the global fit across the mobile phase composition range used in this study for the experimental and calculated retention values (R 2 = 0.994) indicates that the LSER model is an appropriate model of characterizing this polar bonded phase under normal phase conditions. For a limited subset of compounds, retention on the pyridinium bromide SCIL stationary phase is more highly correlated with that obtained on a cyano column than on a diol column under NP conditions.

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Section: 12supporting

confidence: 91%

Section: 11mentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships

Meter

Stuart

Carle

et al. 2008

Journal of Chromatography A

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“…studies on prediction partition coefficients [122], solute-solvent interactions [125], specific descriptors [126], and empirical parameters of solvent potency [156].…”

Section: Applicationsmentioning

confidence: 99%

Multiple Linear Regression: An Overview with Analytical and Physico-Chemical Applications

Martín¹,

Navas²,

Fernandez-Recamales³

et al. 2017

International Journal of Advanced Research in Chemical Science

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Influence of composition and temperature on the selectivity of stationary phases containing either mixtures of poly(ethylene glycol) and poly(dimethylsiloxane) or copolymers of cyanopropylphenylsiloxane and dimethylsiloxane for open-tubular column gas chromatography

Poole¹,

Kiridena²,

Nawas

et al. 2002

J. Sep. Science

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Influence of composition and temperature on the selectivity of stationary phases containing either mixtures of poly(ethylene glycol) and poly(dimethylsiloxane) or copolymers of cyanopropylphenylsiloxane and dimethylsiloxane for open-tubular column gas chromatography The solvation parameter model is used to determine the system constants for three columns containing mixtures of poly(dimethylsiloxane) and poly(ethylene glycol) and a poly(cyanopropylphenyldimethylsiloxane) containing 6% of cyanopropylphenylsiloxane monomer at five equally spaced temperatures in the range 60 -1408C. Together with literature data for a poly(dimethylsiloxane) and a poly(ethylene glycol) stationary phase the influence of temperature and composition on selectivity is studied for mixing ratios of 0 to 1 poly(ethylene glycol) for the temperature range 60 -1408C. Using literature data for two poly(cyanopropylphenyldimethylsiloxane) stationary phases containing 14% and 50% of cyanopropylphenylsiloxane monomer groups the influence of temperature and replacing dimethylsiloxane monomer groups by cyanopropylphenylsiloxane groups on selectivity is studied for incorporation of 0 to 0.5 cyanopropylphenylsiloxane groups over the temperature range 60 -1408C. Addition of poly(ethylene glycol) or introduction of cyanopropylphenylsiloxane monomer groups into a poly(dimethylsiloxane) influences selectivity through an increase in dipolarity/ polarizability, hydrogen-bond basicity, electron lone pair interactions, and changes in cohesion. The changes in system constants as a function of temperature and composition are simply modeled as smooth quadratic response surfaces. Curvature in the response surfaces along the composition axis is significant while changes along the temperature axis are modest for both stationary phase types. Cluster analysis is used to demonstrate that the mixed poly(dimethylsiloxane)/poly(ethylene glycol) stationary phases containing 0.5 and 0.85 weight fraction of poly(ethylene glycol) have different selectivity to a database of common open-tubular column stationary phases. The mixed poly(dimethylsiloxane)/poly(ethylene glycol) stationary phase containing 0.10 weight fraction of poly(ethylene glycol) has similar selectivity to the poly(cyanopropylphenyldimethylsiloxane) containing 6% cyanopropylphenyl monomer groups, and could replace the mixed phase for all but the most critical of separations.

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Solute–solvent interactions in normal-phase liquid chromatography: a linear free-energy relationships study

Cited by 64 publications

References 17 publications

Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships

Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships

Multiple Linear Regression: An Overview with Analytical and Physico-Chemical Applications

Influence of composition and temperature on the selectivity of stationary phases containing either mixtures of poly(ethylene glycol) and poly(dimethylsiloxane) or copolymers of cyanopropylphenylsiloxane and dimethylsiloxane for open-tubular column gas chromatography

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