Solute Carriers in the Blood–Brain Barier: Safety in Abundance

Nałęcz, Katarzyna A.

doi:10.1007/s11064-016-2030-x

Cited by 54 publications

(41 citation statements)

References 173 publications

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“…Numerous transporters are enriched in brain ECs, which generally fall into two categories: efflux and solute transporters (Miller, 2015; Nałęcz, 2017; Strazielle and Ghersi-Egea, 2015; Fig. 1 E).…”

Section: The Nvumentioning

confidence: 99%

The blood–brain barrier in health and disease: Important unanswered questions

Profaci

Munji

Pulido

et al. 2020

Journal of Experimental Medicine

405

358

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The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer’s disease. This review will discuss current knowledge and key unanswered questions regarding the blood–brain barrier in health and disease.

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Section: The Nvumentioning

confidence: 99%

The blood–brain barrier in health and disease: Important unanswered questions

Profaci

Munji

Pulido

et al. 2020

Journal of Experimental Medicine

405

358

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“…Роль эпендимоцитов в нейрогенезе В последние годы достаточно широко обсуждается вопрос участия эпендимальных клеток в нейрогенезе. Однако факт того, что в боковых желудочках взрослого человека отсутствуют эпендимальные клетки, позволяет предположить, что эпендимоциты в нейроге-ОБЗОРНЫЕ СТАТЬИ ® незе участвуют ограниченно, только во внутриутробном периоде развития ЦНС [17][18][19][20].…”

Section: Review Articles фундаментальная и клиническая медицина ®unclassified

“…Доказано, что эпендимальные клетки экспрессируют 48 семейств и 64% представителей SLC-транспортеров. При этом состав транспортеров отличается в норме и при патологии, а также во внутриутробном и постнатальных периодах [19,34]. Таким образом, становится очевидной роль эпендимоцитов в процессах обеспечения структурной, трофической и метаболической поддержки в ЦНС посредством синтеза специфического внеклеточного матрикса, молекул адгезии, высвобождения модуляторов и факторов роста, а также продукции ликвора, участия в нейрогенезе и репаративных процессах [61,62].…”

Section: обзорные статьи Vol 4 № 3 2019 ®unclassified

Brain ependymocytes in neurogenesis and maintaining integrity of blood-cerebrospinal fluid barrier

Успенская¹,

Моргун²,

Осипова³

et al. 2019

Fundamentalʹnaâ i kliničeskaâ medicina

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Here we review the physiology of brain ependymocytes which produce cerebrospinal fluid, regulate neurogenic niches, and contribute to neurogenesis in health and disease. We particularly focus on cilia as these organelles are pivotal to ensure the normal functioning of ependymocytes. The functional activity of ependymocytes is largely defined by their localisation in the central nervous system. Further studies of ependymal cell biology are required to better understand the mechanisms of neurological disorders and to discover novel therapeutic strategies aimed at correcting neurodegeneration and aberrant development of the brain.

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“…The brain expresses MCTs-1, -2, and -4, with MCT-1 being found in endothelial and ependymal cells, as well as in astrocyte endfeet at the BBB (127, 128). MCT-2 is expressed in endothelial cells, but not in astrocytes, whereas MCT-4 appears to be specific for astrocytes (58, 129–131).…”

Section: Functions Of Non-neuronal Cellsmentioning

confidence: 99%

Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals

et al. 2017

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Although the brain is composed of numerous cell types, neurons have received the vast majority of attention in the attempt to understand how this organ functions. Neurons are indeed fundamental but, in order for them to function correctly, they rely on the surrounding “non-neuronal” cells. These different cell types, which include glia, epithelial cells, pericytes, and endothelia, supply essential substances to neurons, in addition to protecting them from dangerous substances and situations. Moreover, it is now clear that non-neuronal cells can also actively participate in determining neuronal signaling outcomes. Due to the increasing problem of obesity in industrialized countries, investigation of the central control of energy balance has greatly increased in attempts to identify new therapeutic targets. This has led to interesting advances in our understanding of how appetite and systemic metabolism are modulated by non-neuronal cells. For example, not only are nutrients and hormones transported into the brain by non-neuronal cells, but these cells can also metabolize these metabolic factors, thus modifying the signals reaching the neurons. The hypothalamus is the main integrating center of incoming metabolic and hormonal signals and interprets this information in order to control appetite and systemic metabolism. Hence, the factors transported and released from surrounding non-neuronal cells will undoubtedly influence metabolic homeostasis. This review focuses on what is known to date regarding the involvement of different cell types in the transport and metabolism of nutrients and hormones in the hypothalamus. The possible involvement of non-neuronal cells, in particular glial cells, in physiopathological outcomes of poor dietary habits and excess weight gain are also discussed.

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Solute Carriers in the Blood–Brain Barier: Safety in Abundance

Cited by 54 publications

References 173 publications

The blood–brain barrier in health and disease: Important unanswered questions

The blood–brain barrier in health and disease: Important unanswered questions

Brain ependymocytes in neurogenesis and maintaining integrity of blood-cerebrospinal fluid barrier

Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals

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