Solute Carrier Family 12 Member 2 as a Proteomic and Histological Biomarker of Dysplasia and Neoplasia in Ulcerative Colitis

Merli, Angela-Maria; Vieujean, Sophie; Massot, Charlotte; Blétard, Noëlla; Calvo, Florence Quesada; Baiwir, Dominique; Mazzucchelli, Gabriel; Servais, Laurence; Wéra, Odile; Oury, Cécile; Leval, Laurence de; Sempoux, Christine; Manzini, Roberto; Bluemel, Sena; Scharl, Michael; Rogler, Gerhard; Pauw, Edwin De; Marques, Carla Coimbra; Colard, A; Vijverman, A; Delvenne, Philippe; Louis, Édouard; Meuwis, Marie‐Alice

doi:10.1093/ecco-jcc/jjaa168

Cited by 5 publications

(4 citation statements)

References 68 publications

(80 reference statements)

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“…In addition, the similar analysis was performed in C3 cancer cells (Additional file 1 : Fig.S2). The main enriched functional genes in C3 groups are SLC12A2 [ 21 ], ATP1B1 [ 22 ], PLA2G2A [ 23 ], and HBEGF [ 24 ]. (Additional file 1 : Fig.S2B).…”

Section: Resultsmentioning

confidence: 99%

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Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

et al. 2023

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The aim of the present study was to elucidate the evolutionary trajectory of colon cells from normal colon mucosa, to adenoma, then to carcinoma in the same microenvironment. Normal colon, adenoma and carcinoma tissues from the same patient were analyzed by single-cell sequencing, which perfectly simulated the process of time-dependent colon cancer due to the same microenvironment. A total of 22 cell types were identified. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0), and Entero5 in carcinoma. Epi1 and Entero0 were Co-enriched in antibacterial and IL-17 signaling, Entero5 was enriched in immune response and mucin-type O-glycan biosynthesis. We discovered new colon cancer related genes including AC007952.4, NEK8, CHRM3, ANO7, B3GNT6, NEURL1, ODC1 and KCNMA1. The function of TBC1D4, LTB, C2CD4A, AND GBP4/5 in T cells needs to be clarified. We used colon samples from the same person, which provide new information for colon cancer therapy.

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Section: Resultsmentioning

confidence: 99%

“…S2). The main enriched functional genes in C3 groups are SLC12A2 [21], ATP1B1 [22], PLA2G2A [23], and HBEGF [24]. (Additional file 1: Fig.…”

Section: C2 Goblet Cells Are the Key Cell Group In The Process Of Car...mentioning

confidence: 99%

Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

et al. 2023

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“…For example, one of his publications is “ Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals ” ( 33 ). Marie-Alice Meuwis has paid attention to proteomics studies of inflammatory bowel diseases ( 34 , 35 ). Thus, the achievements of the top 10 leading co-authors laid the foundation for the research of omics in UC.…”

Section: Discussionmentioning

confidence: 99%

Research trends of omics in ulcerative colitis: A bibliometric analysis

Zhang

et al. 2023

Front. Med.

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BackgroundOmics has emerged as a promising biological science to shed light on the etiology, pathogenesis, and treatment of ulcerative colitis (UC). At present, although research on the omics of UC has drawn global attention, there is still a lack of bibliometric analysis in this field. This study aimed to access the trends and hotspots of omics in UC research.MethodPublications related to omics in UC from 1 January 2000 to 15 October 2022 were retrieved from the Web of Science Core Collection database. VOSviewer, CiteSpace, and the online bibliometric analysis platform “Bibliometrix” were adopted to extract and visualize information.ResultsA total of 385 publications were finally included and the annual number of publications fluctuated. The trend in publications increased rapidly after 2019. The United States showed its dominant position in several publications, total citations, and international collaborations. The top five research organizations for publications on the research of omics in UC were Harvard Medical School, the Icahn School of Medicine at Mount Sinai, Karolinska Institutet, the Brigham and Women's Hospital, and the Massachusetts General Hospital. Ashwin Ananthakrishnan from the Massachusetts General Hospital was the most productive author, and Séverine Vermeire from the Catholic University of Leuven was co-cited most often. Inflammatory bowel disease was the most popular and co-cited journal in this field. The reference with citation bursts and trend topics showed that “ulcerative colitis,” “inflammatory bowel disease,” “microbiome,” “transcriptomics,” “genomics,” “metabolomics,” “proteomics,” “dysbiosis,” “biomarkers,” “loci,” and “therapy” are currently research hotspots.ConclusionOur study presents several important insights into the research trends and developments in the field of omics in UC, which will provide key information for further research.

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“…In 2020, Merli AM et al [65] assessed dysplastic, inflammatory, and normal-appearing mucosal regions in five patients with UC. They identified 11 proteins upregulated in dysplastic regions compared to non-dysplastic tissue.…”

Section: Proteomics For the Selection Of Biomarkers Of Neoplastic Tra...mentioning

confidence: 99%

A Current State of Proteomics in Adult and Pediatric Inflammatory Bowel Diseases: A Systematic Search and Review

Fabián

Bajer

Drastich

et al. 2023

IJMS

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Inflammatory bowel diseases (IBD) are systemic immune-mediated conditions with predilection for the gastrointestinal tract and include Crohn’s disease and ulcerative colitis. Despite the advances in the fields of basic and applied research, the etiopathogenesis remains largely unknown. As a result, only one third of the patients achieve endoscopic remission. A substantial portion of the patients also develop severe clinical complications or neoplasia. The need for novel biomarkers that can enhance diagnostic accuracy, more precisely reflect disease activity, and predict a complicated disease course, thus, remains high. Genomic and transcriptomic studies contributed substantially to our understanding of the immunopathological pathways involved in disease initiation and progression. However, eventual genomic alterations do not necessarily translate into the final clinical picture. Proteomics may represent a missing link between the genome, transcriptome, and phenotypical presentation of the disease. Based on the analysis of a large spectrum of proteins in tissues, it seems to be a promising method for the identification of new biomarkers. This systematic search and review summarize the current state of proteomics in human IBD. It comments on the utility of proteomics in research, describes the basic proteomic techniques, and provides an up-to-date overview of available studies in both adult and pediatric IBD.

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Solute Carrier Family 12 Member 2 as a Proteomic and Histological Biomarker of Dysplasia and Neoplasia in Ulcerative Colitis

Cited by 5 publications

References 68 publications

Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

Research trends of omics in ulcerative colitis: A bibliometric analysis

A Current State of Proteomics in Adult and Pediatric Inflammatory Bowel Diseases: A Systematic Search and Review

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