Solute and penetrant diffusion in swellable polymers. I. Mathematical modeling

Korsmeyer, Richard W.; Lustig, Steven R.; Peppas, Nikolaos A.

doi:10.1002/polb.1986.090240214

Cited by 245 publications

(149 citation statements)

References 6 publications

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“…Although there is an abundance of data in the literature on the dissolution time of particles of ordinary solutions, there are no reported data on the dissolution time of polymeric particles of different sizes. There are also a number of publications on the dissolution of bioerodible hydrogels (Heller, 1978;Korsmeyer et al, 1986;Lee, 1987). However, the dissolution process of bioerodible hydrogels is essentially controlled by the molecular weight degradation rates.…”

Section: Experimental Validation Of the Modelmentioning

confidence: 99%

Convective diffusion from a dissolving polymeric particle

Ranade¹,

Mashelkar²

1995

AIChE Journal

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Section: Experimental Validation Of the Modelmentioning

confidence: 99%

Convective diffusion from a dissolving polymeric particle

Ranade¹,

Mashelkar²

1995

AIChE Journal

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“…Lustig and Peppas [49] ( [52], to describe the transport of both the solvent ( i = 1 ) and the solute ( i = 3 ) within the polymeric network:…”

Section: Free Volume Theorymentioning

confidence: 99%

Swellable Hydrogel-based Systems for Controlled Drug Delivery

Caccavo¹,

Cascone²,

Lamberti³

et al. 2016

Smart Drug Delivery System

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The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent the simplest and the most traditional dosage systems based on hydrogel. Their formulation and preparation require to mix and to compress, in proper ratios, various excipients, including a swellable polymer and a drug. Carriers for controlled release systems are usually cross-linked polymers able to form hydrogels that show peculiar release mechanisms, where both diffusion and tablet swelling play important roles.When a dry swellable hydrogel-based matrix is immersed in a physiological fluid, this starts to penetrate inside the polymeric hydrophilic matrix. When a certain solvent concentration is reached, the polymeric chains unfold due to a glass-rubber transition, and a gel-like layer is formed. In the swollen region, the drug molecules can easily diffuse toward the outer dissolution medium, once they are dissolved. The polymer network became extremely hydrated where the swollen matrix is in contact with the outer medium, and processes like chain disentanglement take place, "eroding" the matrix.This chapter is focused on the analysis of the state of the art about the uses of carriers for controlled release systems composed by hydrogel-based matrices. This analysis has been performed studying in deep both the experimental and the modeling techniques which have been investigated over the years to characterize all the phenomena involved during the drug release.

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“…The free volume theory simplification originally proposed by Korsmeyer et al 18 utilizes coefficients /3, and which are material constants. The relative time scales for the penetrant sorption and solute release differ by the ratio of the solute diffusivity in the swollen gel, I)+, to the penetrant diffusivity in the swollen gel, Ill, s.…”

Section: Lomentioning

confidence: 99%

Solute and penetrant diffusion in swellable polymers. VII. A free volume-based model with mechanical relaxation

Lustig

Peppas

1987

J. Appl. Polym. Sci.

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SynopsisPenetrant transport through and solute release from continuously swelling polymers is viewed as a process d a t e d with major structural changes in the polymer morphology. Changes in the diffusivities of penetrant and solute reflect a free volume mechanism for transport. The polymer is initially glassy with a uniform dispersion of solute. After the system is placed in contact with a thermodynamically good penetrant, a glassy/rubbery phase transition occurs at a well defined swelling interface. The Fickian equations with concentration-dependent diffusivities and moving boundaries are solved simultaneously in polymer-fixed coordinates. A constitutive relation is used to describe the effect of macromolecular relaxations on the rate of volume expansion as the polymer swells. The penetrant fractional uptake, solute fractional release, sample dimensions, swelling front position, and instantaneous swelling interface number are determined and related to the nature of the swelling process.

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Solute and penetrant diffusion in swellable polymers. I. Mathematical modeling

Cited by 245 publications

References 6 publications

Convective diffusion from a dissolving polymeric particle

Convective diffusion from a dissolving polymeric particle

Swellable Hydrogel-based Systems for Controlled Drug Delivery

Solute and penetrant diffusion in swellable polymers. VII. A free volume-based model with mechanical relaxation

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