Soluble β-1,3/1,6-glucan in seaweed from the southern hemisphere and its immunomodulatory effect

Bobadilla, Francisca; Rodríguez-Tirado, Carolina; Imarai, Mónica; Galotto, María José; Andersson, Roger

doi:10.1016/j.carbpol.2012.09.071

Cited by 52 publications

(27 citation statements)

References 30 publications

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“…The highest level of β ‐glucan was found in C. nodosa (13.04±0.42 g/100 g), seagrass, and the lowest was in C. bursa (2.43±0.23 g/100 g), brown seaweed ( Table ). In comparison to results of Bobadilla et al . that have found for Durvillaea antarctica ( Chamisso ) Hariot (DA) (significant immunomodulatory activity because of high content of 1,3 : 1,6‐ β ‐ d ‐glucan (4–15 g/100 g)), we can assume that C. nodosa and C. barbata have potentially high immunostimulatory activity.…”

Section: Resultssupporting

confidence: 47%

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Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro

Milović

Stanković

Nikolić

et al. 2019

Chemistry & Biodiversity

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Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7‐sulfate, caftaric and coutaric acid). The content of β‐glucan, fatty acids, sterols and micro‐ and macro‐elements were investigated among all samples. The highest content of β‐glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β‐sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).

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Section: Resultssupporting

confidence: 47%

“…An interest in finding new sources of β ‐glucan increase, and algae, certainly, might be one of them. Bobadilla et al . detected a water‐soluble form of β ‐1,3/1,6‐glucan from brown algae and described its immunostimulatory effect.…”

Section: Introductionmentioning

confidence: 99%

Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro

Milović

Stanković

Nikolić

et al. 2019

Chemistry & Biodiversity

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“…The small absorption bands at about 898 cm −1 in the spectrum could be associated with β- d -glycosidic linkages between the pyranose units [8]. As the main component of DAP are glucose, the presence of β- d -glucan with pyran group in DAP could be deduced [16,28,29]. It was reported by other researchers that β- d -glucan is a polysaccharide with known significant biological functionality, for example: cytotoxic macrophage activation, anti-diabetic effects, promoting the differentiation of T cells, and so on, for some immune functions [12,30,31].…”

Section: Discussionmentioning

confidence: 99%

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

Chen

et al. 2016

IJMS

106

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Four seaweed polysaccharides were extracted from Sarcodia ceylonensis, Ulva lactuca L., Gracilaria lemaneiformis, and Durvillaea antarctica, respectively, by microwave-assisted extraction. The effect of three significant variables (extraction time, extraction temperature, and the ratio of water to raw material) on the process for extracting polysaccharides was investigated, along with the optimization of the extraction using the response surface method (RSM) with a Box–Behnken design. The polysaccharide structure, monosaccharide composition, degree of sulfation, and molecular weight (MW) distribution were analyzed by infrared (IR) spectrometry, gas chromatography (GC), and high-performance gel permeation chromatography (HPGPC). IR spectrometry showed that Sarcodia ceylonensis polysaccharide (SCP), Ulva lactuca L. polysaccharide (ULLP), and Durvillaea antarctica polysaccharide (DAP) were all sulfated polysaccharides and, except Gracilaria lemaneiformis polysaccharide (GLP), all belong to β-pyranosidic polysaccharides. The average molecular weight (MW) of SCP, ULLP, GLP, and DAP was 466, 404, 591, and 482 kDa, respectively. The quantitative and comparative results with external standards indicated that the main monosaccharide in SCP and ULLP was mannose; and GLP and DAP were mainly composed of galactose and glucose, respectively. Then the in vitro antioxidant activity of all of the polysaccharides was evaluated using different assays—2,2–azino –bis (3-ethylbenzthiazoline-6- sulfonate) (ABTS), hydroxyl radical, nitrite scavenging capacity, and reducing power—and the relationship between their antioxidant activity and chemical characteristics were also examined. ULLP presented the highest ABTS radical scavenging activity; ULLP, SCP and DAP also showed a strong effect on the ABTS radical scavenging activity. SCP and ULLP exhibited excellent hydroxyl radical scavenging activities, about 83.33% ± 2.31% and 80.07% ± 2.17%, respectively, at 4 mg/mL. The reducing power of DAP was relatively more pronounced than that of the three other polysaccharides. However, the nitrite scavenging activities of the four seaweed polysaccharides were weaker than other antioxidant activity (ABTS), hydroxyl radical scavenging capacity, and reducing power. In addition, GLP exhibited lower activities than the other three samples in all of the tests for the antioxidant activity.

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“…However, further research has to be conducted to identify the optimum ratio of this sea weed to be added to the fish feed, for getting the best immunity level. According to Bobadilla et al (2012), the brown algae has characterized the properties of β-glucan which is a naturally occurring non-specific immunestimulants. The immuno-stimulants are promising dietary supplement to potentially aid in disease control of several organisms including marine fish and increase disease resistance by regulating host defense mechanisms against opportunistic microorganisms in the environment (Galindo and Hosokawa 2004 Approximately Rs.…”

Section: Resultsmentioning

confidence: 99%

A comparative laboratory trial on the effect of Sargassum wightii incorporated formulated feed on growth performance and immunity development of Asian sea bass <em>Lates calcarifer</em> (Bloch 1790): can it be an alternative to commercial feed?

Kodithuwakku

Parakrama

Heenatigala

et al. 2017

Sri Lanka J. Aquat.

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Asian sea bass (Lates calcarifer) is a high valued seafood throughout the world. Bacterial infections can cause huge losses in Asian sea bass culture and among them Aeromonas hydrophila is ubiquitous. Inclusion of bioactive compounds present in seaweeds into fish diets can enhance the fish growth and immunity combating the bacterial diseases. This study was conducted to determine whether feeding with Sargassum wightii incorporated feed could enhance immunity of the fish to bacterial infections. A feed trial was conducted using four treatments comprising a commercial feed, two formulated feeds incorporated with 20 g/kg and 40g/kg of S. wightii in each feed and a formulated feed without seaweed as the control diet. Three replicate tanks stocked with 15 advanced fingerlings were used for the each treatment and reared 40 days under the optimum conditions. Growth parameters were tested and effect of different feeds on growth performance was evaluated. Fish survival rate and cost of formulated feed were calculated. At the end of feed trial, nine fishes from each treatment were artificially challenged with 1.50 ppm dose of A. hydrophila and observed for 7 days. There was a significant difference in weight gain in commercial feed compared to other three treatments (P<0.05), while there was no significant difference in FCR and SGR among all experimental diets (P>0.05). The challenge with A. hydrophila showed 11.1% disease prevalence in L. calcarifer fed with 20g/kg of seaweed incorporated feed. Highest disease prevalence of 100% was recorded in fish that had been fed with the seaweed free formulation. The highest level of immunity enhancement was reported using the feed that contained 20g/kg seaweed. Production cost of formulated feed was lower than the commercial feed.

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Soluble β-1,3/1,6-glucan in seaweed from the southern hemisphere and its immunomodulatory effect

Cited by 52 publications

References 30 publications

Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro

Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

A comparative laboratory trial on the effect of Sargassum wightii incorporated formulated feed on growth performance and immunity development of Asian sea bass <em>Lates calcarifer</em> (Bloch 1790): can it be an alternative to commercial feed?

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