Soluble Vascular Cell Adhesion Molecule and Cardiovascular Disease: An Epidemiological View

Yamagishi, Kazumasa; Iso, Hiroyasu

doi:10.5551/jat.ed074

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…To assess the in vitro endothelial damage in sera, we selected from the in vivo analysed biomarkers, established markers of endothelial activation and dysfunctional haemostasis and thrombogenicity. VCAM‐1 has been demonstrated in various studies to have a high correlation with human atherosclerosis . Levels of VCAM‐1 have been also reported to be increased in a CS follow‐up study performed in the same patients before and a short time after remission .…”

Section: Discussionmentioning

confidence: 82%

“…Circulatory markers of endothelial injury are heterogeneous and depend on sample size, patient age, and, for CS, time elapsed following remission, along with other confounding factors. Generally, their prognostic value related to cardiovascular disease has been reported in studies with large sample size or great longitudinal follow‐up, which is difficult to achieve in CS …”

Section: Introductionmentioning

confidence: 99%

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Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing syndrome after remission

Aranda

Fernández-Ruiz

Palomo

et al. 2017

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing syndrome after remission

Aranda

Fernández-Ruiz

Palomo

et al. 2017

Clinical Endocrinology

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“…factors, chemokines, matrix metalloproteinases and other cytokines play important roles in the development and progression of ADEM [7][8][9][10]. Experimental autoimmune encephalomyelitis (EAE) is a delayed-type hypersensitivity autoimmune disease that occurs in experimental animals and confined in the nervous system.…”

Section: Adhesionmentioning

confidence: 99%

Effect of mesenchymal stem cell transplantation on behavior and structural changes in myelin in experimental rat autoimmune encephalomyelitis

Zhang¹,

Wang²,

Fan³

et al. 2019

Trop. J. Pharm Res

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Purpose: To investigate the effect of bone marrow mesenchymal stem cell (BM-MSC) transplantation on behavior and structural changes in myelin of experimental autoimmune encephalomyelitis (EAE) in rats. Methods: Wistar rats were randomly assigned to normal control, EAE, placebo injection treatment, and MSCs treatment. EAE, placebo injection treatment and MSCs treatment groups were further divided into six groups, i.e., 1-day, 3-day, 7-day, 14-day, 21-day, and 28-day post-onset. Changes in the disease status of the rats and structural changes in myelin at different time points were assessed with silver staining. Results: Behavioral changes peaked between 13 to 17 days post-immunization (71.90 % incidence), while disease symptoms peaked between 3 and 5 days after onset, were sustained for about 7 days, and then eased gradually thereafter. The highest therapeutic scores and the entire course of the disease in EAE and placebo treatment groups were not significantly different (p > 0.05). However, in MSC treatment group, these parameters were significantly lower than in the above two groups (p < 0.05). In EAE and placebo treatment groups, myelin sheath lesions were obvious from day 3 to 7 but on day 14, the number of myelin sheath fragments decreased significantly. Recovery at different time points was also better than those in EAE and placebo treatment groups. Conclusion: MSC transplantation shortens the course of EAE, and also reduces its severity. Thus, it has some prospects for use in the management of EAE.

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Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis

et al. 2020

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Soluble Vascular Cell Adhesion Molecule and Cardiovascular Disease: An Epidemiological View

Cited by 4 publications

References 5 publications

Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing syndrome after remission

Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing syndrome after remission

Effect of mesenchymal stem cell transplantation on behavior and structural changes in myelin in experimental rat autoimmune encephalomyelitis

Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis

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