Soluble vascular cell-adhesion molecule-1 and soluble intercellular adhesion molecule-1 correlate with lipid and apolipoprotein risk factors for coronary artery disease in children

Ohta, T; Saku, Keijiro; Takata, Kazuhide; Adachi, Naoto

doi:10.1007/s004310051154

Cited by 35 publications

(13 citation statements)

References 43 publications

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“…16 A negative correlation between the age of young patients and the concentrations in adhesion molecules supports the findings of Ohta et al, who first described the clinical usefulness of assessing adhesion molecules as a marker of the first phase of atherosclerosis in children. 17 Our study confirmed the endothelial activation in obese children and the negative correlation between the age of children and the concentrations of sE.…”

Section: Discussionsupporting

confidence: 90%

“…[16][17][18][19][20] showed that the concentrations of sICAM-1 and sVCAM-1 were significantly greater in children than in adults, and these concentra- tions were found to decline with age. 16 A negative correlation between the age of young patients and the concentrations in adhesion molecules supports the findings of Ohta et al, who first described the clinical usefulness of assessing adhesion molecules as a marker of the first phase of atherosclerosis in children.…”

Section: Discussionmentioning

confidence: 93%

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Endothelial activation and systemic inflammation in obese asthmatic children

Huang¹,

Del-Río-Navarro

Monge

et al. 2008

allergy asthma proc

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Asthma and obesity are prevalent disorders, each with a significant impact on the public health. The causality relating obesity and asthma has not been established. The objective of this article is to investigate whether asthma could exacerbate the endothelial activation and to determine the relationship between systemic inflammation and endothelial activation in obese asthmatic children. Eighty-nine children (10-16 years old) were divided according to their diagnosis (asthma, obese nonasthmatic, and obese asthmatic children). Twenty healthy children formed the control group. Three adhesion molecules (E-selectin, sICAM-1, and sVCAM-1) and C-reactive protein (CRP) were measured in serum samples. The levels of sICAM-1 were significantly higher in obese nonasthmatic and obese asthmatic children versus control and lean asthmatic children (414.7+/-154.7, 434.9+/-181.1, 238.6+/-117.8, and 351.2+/-153.5 ng/mL, respectively). No difference was observed between obese nonasthmatic and obese asthmatic groups. No difference of the levels of CRP, E-selectin, and sVCAM-1 was found among the study groups. Correlation analysis showed that E-selectin associated significantly with body mass index (BMI), CRP and the other two adhesion molecules. CRP depended on BMI. sICAM-1 associated with CRP, BMI, and triglycerides. Correlations were verified in multiple regression analysis models in the whole study groups: CRP levels depended on sICAM-1, E-selectin, and sICAM-1 concentrations depended on BMI. Correlations were verified in asthmatic subjects: CRP depended on sICAM-1. These results confirmed the endothelial activation in obese children. Mild nonallergic asthma in our study did not exacerbate the endothelial activation in obese or lean asthmatic children. Significant association between systemic inflammation and endothelial activation was observed in asthmatic children.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 93%

Endothelial activation and systemic inflammation in obese asthmatic children

Huang¹,

Del-Río-Navarro

Monge

et al. 2008

allergy asthma proc

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“…These findings are in part and not entirely consistent with recently provided evidence by Ohta et al (26) in a childhood Japanese population. In that study an association of sVCAM-1 and sICAM-1 and serum lipid profile was identified whereas sE-selectin values were not determined and sP-selectin levels did not correlate with any lipid fraction.…”

Section: Discussionsupporting

confidence: 68%

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

Kavazarakis

2002

Pediatric Research

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“…Ohta, Saku, Takata et al 1999, Rohde et al 1999) others do not (Hwang et al 1997, Saku, Zhang, Ohta et al 1999) may be attributable to the small sample sizes and the selection biases of clinically based studies, in which`control' subjects are available due to their need for diagnostic services (e.g. echocardiography) .…”

Section: Discussionmentioning

confidence: 96%

The relationship of soluble ICAM-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women

Demerath

Towne

Blangero

et al. 2001

Annals of Human Biology

122

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There were no sex differences in the concentrations of sICAM-1, sVCAM-1 and sPSEL, but men had higher sESEL levels than women (p < 0.0001). Male and female smokers had higher sICAM-1 and sESEL levels than non-smokers and soluble cell adhesion molecules (CAMs) were correlated with the pack-years of cigarette smoking (r = 0.3-0.4, p < 0.0001, significant in women only). Significant independent associations were found between soluble CAMs and smoking, waist-hip ratio (WHR), blood pressure, high density lipoprotein cholesterol and total cholesterol. Furthermore, significant interaction effects were found in women, such that the relationship between CAMs and lipid concentrations and WHR were stronger in smokers than non-smokers. In conclusion, the concentration of soluble CAMs, particularly sICAM-1 and sESEL, reflect the level of established CVD risk factors in apparently healthy men and women, adding to the evidence that these factors contribute to CVD through their inflammatory effects on the vascular endothelium.

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Soluble vascular cell-adhesion molecule-1 and soluble intercellular adhesion molecule-1 correlate with lipid and apolipoprotein risk factors for coronary artery disease in children

Abstract: Our data indicate that intervention to normalize risk factors for coronary artery disease should be started at a young age to prevent increased expression of cell adhesion molecules.

Cited by 35 publications

References 43 publications

Endothelial activation and systemic inflammation in obese asthmatic children

Endothelial activation and systemic inflammation in obese asthmatic children

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

The relationship of soluble ICAM-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women

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