Soluble urokinase-type plasminogen activator receptor (suPAR) as new biomarker of the prosthetic joint infection: Correlation with inflammatory cytokines

Galliera, Emanuela; Drago, Lorenzo; Marazzi, Monica Gioia; Romanò, Carlo Luca; Vassena, Christian; Romanelli, Massimiliano Marco Corsi

doi:10.1016/j.cca.2014.11.029

Cited by 32 publications

(26 citation statements)

References 37 publications

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“…The correlation, however, was weak in comparison to previously reported results (35, 40) possibly indicating that there are numerous factors influencing inflammatory biomarkers and mediators in aSAH. In addition, although higher age was associated with poor outcome per se , in our patient cohort, we observed no correlation between age and plasma suPAR levels.…”

Section: Discussioncontrasting

confidence: 99%

Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Is Not Associated with Neurological Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage

et al. 2017

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ObjectAneurysmal subarachnoid hemorrhage (aSAH) is a common cause of death or long-term disability. Despite advances in neurocritical care, there is still only a very limited ability to monitor the development of secondary brain injury or to predict neurological outcome after aSAH. Soluble urokinase-type plasminogen activator receptor (suPAR) has shown potential as a prognostic and as an inflammatory biomarker in a wide range of critical illnesses since it displays an association with overall immune system activation. This is the first time that suPAR has been evaluated as a prognostic biomarker in aSAH.MethodsIn this prospective population-based study, plasma suPAR levels were measured in aSAH patients (n = 47) for up to 5 days. suPAR was measured at 0, 12, and 24 h after patient admission to the intensive care unit (ICU) and daily thereafter until he/she was transferred from the ICU. The patients’ neurological outcome was evaluated with the modified Rankin Scale (mRS) at 6 months after aSAH.ResultssuPAR levels (n = 47) during the first 24 h after aSAH were comparable in groups with a favorable (mRS 0–2) or an unfavorable (mRS 3–6) outcome. suPAR levels during the first 24 h were not associated with the findings in the primary brain CT, with acute hydrocephalus, or with antimicrobial medication use during 5-days’ follow-up. suPAR levels were associated with generally accepted inflammatory biomarkers (C-reactive protein, leukocyte count).ConclusionPlasma suPAR level was not associated with either neurological outcome or selected clinical conditions. While suPAR is a promising biomarker for prognostication in several conditions requiring intensive care, it did not reveal any value as a prognostic biomarker after aSAH.

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Section: Discussioncontrasting

confidence: 99%

Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Is Not Associated with Neurological Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage

et al. 2017

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“…Under inflammatory conditions, uPAR is released from the cell surface generating a soluble form of the receptor (suPAR) with intrinsic chemotactic properties [17]. suPAR is a stable biomarker, both in vivo and in vitro [18, 19], and is positively correlated with labile pro-inflammatory cytokines such as IL-1β and TNF-α as well as with C-reactive protein [20]. Elevated levels are associated with increased risk of CVD, type 2 diabetes, chronic kidney disease, cancer, and premature death in the general population [21–24].…”

Section: Introductionmentioning

confidence: 99%

Healthy lifestyles reduce suPAR and mortality in a Danish general population study

et al. 2019

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BackgroundThe plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is a strong predictor of disease development and premature mortality in the general population. Unhealthy lifestyle habits such as smoking or unhealthy eating is known to elevate the suPAR level. We aimed to investigate whether change in lifestyle habits impact on the suPAR level, and whether the resultant levels are associated with mortality.ResultsPaired suPAR measurements from baseline- and the 5-year visit of the population-based Inter99 study were compared with the habits of diet, smoking, alcohol consumption, and physical activity. Paired suPAR measurements for 3225 individuals were analyzed by linear regression, adjusted for demographics and lifestyle habits. Compared to individuals with a healthy lifestyle, an unhealthy diet, low physical activity, and daily smoking were associated with a 5.9, 12.8, and 17.6% higher 5-year suPAR, respectively. During 6.1 years of follow-up after the 5-year visit, 1.6% of those with a low suPAR (mean 2.93 ng/ml) died compared with 3.8% of individuals with a high suPAR (mean 4.73 ng/ml), P < 0.001. In Cox regression analysis, adjusted for demographics and lifestyle, the hazard ratio for mortality per 5-year suPAR doubling was 2.03 (95% CI: 1.22–3.37).ConclusionLifestyle has a considerable impact on suPAR levels; the combination of unhealthy habits was associated with 44% higher 5-year suPAR values and the 5-year suPAR was a strong predictor of mortality. We propose suPAR as a candidate biomarker for lifestyle changes as well as the subsequent risk of mortality.

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“…Commensurate with the increasing number of prosthetic joints being implanted, the total number of patients diagnosed and treated for prosthetic joint infections (PJI) is rising 4, 10, 12, 14. PJI is among the most common causes of failure of total joint arthroplasty, resulting in additional procedures, increased health care costs, and increased morbidity 3, 8, 14. Although the Infectious Diseases Society of America published guidelines in 2012 10 to help guide clinicians in the diagnosis and management of PJI, these guidelines primarily focus on the commonly encountered pathogens associated with PJI, namely Staphylococcus and Streptococcus species, and do not as comprehensively address the management of less commonly encountered organisms associated with PJI such as Pseudomonas sp..…”

Section: Introductionmentioning

confidence: 99%

Pseudomonas Prosthetic Joint Infections: A Review of 102 Episodes

Shah

Osmon

Steckelberg

et al. 2016

J. Bone Joint Infect.

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Background: The outcome of patients with Pseudomonas prosthetic joint infection (PS PJI) has not been well studied. The aim of this retrospective cohort study was to assess the outcome of patients with Pseudomonas PJI and to review risk factors associated with failure of therapy.Methods: Between 1/1969 and 12/2012, 102 episodes of PS PJI in 91 patients were identified.Results: The mean age at the time of diagnosis was 67.4 years; forty three percent had knee involvement. Over 40 percent had either diabetes mellitus or a history of gastrointestinal or genitourinary surgery. Nearly half (48 out of 102 episodes) received aminoglycoside monotherapy, while 25% received an anti-pseudomonal cephalosporin. The 2-year cumulative survival free from failure was 69% (95% CI, 56%-82%). Patients treated with resection arthroplasty, two-stage exchange, and debridement with implant retention had a 2-year cumulative survival free from failure of 80% (95% CI, 66%-95%), 83% (95% CI, 60%-100%), and 26% (95% CI, 23%-29%) respectively (P=0.0001).Conclusions: PS PJI's are associated with a high failure rate. Patients treated with debridement and implant retention had a worse outcome.

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Soluble urokinase-type plasminogen activator receptor (suPAR) as new biomarker of the prosthetic joint infection: Correlation with inflammatory cytokines

Cited by 32 publications

References 37 publications

Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Is Not Associated with Neurological Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage

Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Is Not Associated with Neurological Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage

Healthy lifestyles reduce suPAR and mortality in a Danish general population study

Pseudomonas Prosthetic Joint Infections: A Review of 102 Episodes

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