Soluble urokinase-type plasminogen activator receptor (suPAR) and interleukin-6 levels in hyperemesis gravidarum

Desdicioğlu, Raziye; Yıldırım, Melahat; Kocaoglu, Gulcan; Çendek, Büşra Demir; Avcıoğlu, Gamze; Taş, Emre Erdem; Şengül, Özlem; Erel, Özcan; Yavuz, Ayşe Filiz

doi:10.1016/j.jcma.2017.08.013

Cited by 5 publications

(9 citation statements)

References 29 publications

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“…28,29 In a study of serum soluble urokinase-type plasminogen activator receptor (suPAR) level was found to be significantly higher in pregnant women diagnosed with HG in the first trimester compared to the control group. 30 Adenosine deaminase (ADA) activity has been shown to be significantly increased in patients with HG. 31 Oxidative stress, also known to be related to inflammatory processes, is emphasized in HG.…”

Section: Discussionmentioning

confidence: 99%

Association between platelet to lymphocyte ratio and plateletcrit with the presence of hyperemesis gravidarum: A case-control study

Massious

Jawad

2020

Zanco J. Med. Sci.

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Nausea and vomiting are very frequent complaints of pregnant women. Erroneously called "morning sickness" in 80% of these women, symptoms may continue throughout the day. Seventy-five percent of pregnant women express nausea and vomiting, lasting an average of 35 days. Half of them will report relief by 14 weeks and 90% by 22 weeks. 1,2 Women with severe nausea and excessive vomiting during pregnancy have hyperemesis gravidarum (HG) which occurs in approximately 0.3-2% of pregnancies. 3 Various HG definitions combine a number of symptoms that include protracted vomiting and nausea in pregnancy, accompanied by weight loss, disturbance of electrolyte balance, ketonuria, and dehydration or hospitalization; however, there are no unequivocal diagnostic criteria for HG as it is a diagnosis of exclusion. 4 Risk factors reported to be associated with NVP and hyperemesis are low maternal age, first parity, 5 female offspring, 6-8 multiple pregnancy, 7 hyperthyroidism, molar pregnancy, gastrointestinal disorders, Background and objective: Hyperemesis gravidarum can be defined as intractable nausea and vomiting, leading to electrolyte imbalance, ketonuria, nutrition deficiency, and weight loss during pregnancy. This study aimed to investigate the association of the platelet to lymphocyte ratio and plateletcrit with the presence of hyperemesis gravidarum. Methods: A case-control study was conducted at Maternity Teaching Hospital in Erbil city, Kurdistan region of Iraq, between January 1st, 2017 and January 1st, 2018. A convenience sample of 120 pregnant women, of which 60 of them with a diagnosis of hyperemesis gravidarum admitted to the emergency department, were regarded as cases. The other 60 visited the outpatient department with mild discomfort, but not having hyperemesis gravidarum were regarded as controls. Age, gestational age, gravida, parity, height, and weight and laboratory parameters, including complete blood count from which we had platelet to lymphocyte ratio and plateletcrit %, were recorded on a specially designed questionnaire. Chi-square test, Fisher's exact test, Student's t-test, Youden's index were used to determine the associations. Results: The platelet to lymphocyte ratio and plateletcrit were higher in the hyperemesis gravidarum groups than controls (P <0.001). The area under the curve for platelet to lymphocyte ratio and plateletcrit were 0.887 and 0.936, respectively, with P <0.001. Platelet to lymphocyte ratio >145.07 and plateletcrit >0.205% were significantly related to an increased risk of hyperemesis gravidarum. Conclusion: The platelet to lymphocyte ratio and plateletcrit are higher in hyperemesis gravidarum cases and may have a predictive value of the development of hyperemesis gravidarum as further studies needed in the future to confirm.

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Section: Discussionmentioning

confidence: 99%

Association between platelet to lymphocyte ratio and plateletcrit with the presence of hyperemesis gravidarum: A case-control study

Massious

Jawad

2020

Zanco J. Med. Sci.

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“…Several studies have proposed to show that the etiology of HG is multifactorial. 2,4,7 Several factors have been suspected to play role of etiopathogenesis HG, including elevated of hCG, 3,4,7,8,11 estrogen, 3,4,7 progesterone, 3,4,7 PGE2, gastric dysmotility, 3,4 immunology, and inflammation 3,8,17 and infection of H. pylori. 3,4,7,8…”

Section: Etiology a N D Pathophysiology O F Hgmentioning

confidence: 99%

“…During pregnancy, there is an increase in certain subsets of immune cells (granulocyte, natural killer cell, and T cells), 3,17 interleukin 4, interleukin 6 (IL-6), tumor necrosis factor α, immunoglobulin IgG and IgM, and complements have been found to be increased in HG. 3,17 Research from Desdicioglu et al showed a significant increase of soluble urokinase-type plasminogen activator receptor (suPAR) and IL-6 in women with HG compared to women without HG as a control group. 17 According to that study results, increased levels of suPAR and IL-6 in HG group could be suggested associated with the etiopathogenesis of HG.…”

Section: Immunology and Inflammationmentioning

confidence: 99%

“…3,17 Research from Desdicioglu et al showed a significant increase of soluble urokinase-type plasminogen activator receptor (suPAR) and IL-6 in women with HG compared to women without HG as a control group. 17 According to that study results, increased levels of suPAR and IL-6 in HG group could be suggested associated with the etiopathogenesis of HG. That supported by some conditions such as steroid-using in HG patients shows dramatic improvement of the symptoms.…”

Section: Immunology and Inflammationmentioning

confidence: 99%

“…2,3,[13][14][15] Etiology and pathophysiology of HG are certainly unknown. 2,3,5,16,17 Several etiologies have been suspected play a role in HG, including elevated human chorionic gonadotropin (hCG), 3,4,7,8,11 estrogen, progesterone, 3,4,7 prostaglandin E2 (PGE2), 3,4 gastric dysmotility, 3,4 immunology, and inflammation 3,8 also infection of Helicobacter pylori. 3,4,7,8 Recent several studies show relations between HG and mild to severe maternal and fetal outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyperemesis Gravidarum: A Holistic Review and Approach to Etiopathogenesis, Clinical Diagnostic and Management Therapy

Simanjuntak¹,

Andrian²,

Wibowo³

et al. 2016

Journal of South Asian Federation of Obstetrics and Gynaecology

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Aim:To provide an overview of hyperemesis gravidarum (HG) and to present possible links between factors associated with the pathogenesis of HG also the effectiveness and safety of the nonpharmacologic and pharmacologic options available to treat HG. Background: Although HG incidence is 0.3-2% worldwide, it is the number one cause of hospitalization in the first-trimester pregnancy, costs greatly to one financially, and also reduces the quality of life. This literature review focuses on articles published over the last 7 years to examine current perspectives and recent developments in HG. Review results: Nausea and vomiting are common symptoms during early pregnancy. When vomiting is severe, it is referred to as HG. Despite its high prevalence, it tends to be underestimated. The etiopathogenesis remains unknown, but many risk factors have been determined. Currently, the therapy focused on improving the symptoms while minimizing risks to the mother and fetus. If HG is left untreated, it may lead to significant maternal morbidity and adverse birth outcomes. Conclusion: Hyperemesis gravidarum is a complex and multifactorial condition. The incidence is higher in developing countries rather than in developed countries. Hyperemesis gravidarum can manifest as mild to severe signs and symptoms. The therapy ranges from dietary and lifestyle changes, intravenous fluid rehydration, hospitalization, nonpharmacologic, and pharmacologic treatment. Hyperemesis gravidarum can result as a mild to severe maternal and fetal complications.

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Outstanding research paper awards of the Journal of the Chinese Medical Association in 2018

Wang

2019

Journal of the Chinese Medical Association

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Soluble urokinase-type plasminogen activator receptor (suPAR) and interleukin-6 levels in hyperemesis gravidarum

Abstract: Serum suPAR and IL-6 levels proved to be high in the HG group. It is likely that suPAR could play a role in the etiopathogenesis of hyperemesis gravidarum.

Cited by 5 publications

References 29 publications

Association between platelet to lymphocyte ratio and plateletcrit with the presence of hyperemesis gravidarum: A case-control study

Association between platelet to lymphocyte ratio and plateletcrit with the presence of hyperemesis gravidarum: A case-control study

Hyperemesis Gravidarum: A Holistic Review and Approach to Etiopathogenesis, Clinical Diagnostic and Management Therapy

Outstanding research paper awards of the Journal of the Chinese Medical Association in 2018

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