Soluble urokinase plasminogen activator receptor (suPAR) for assessment of disease severity in ventilator-associated pneumonia and sepsis

Urokinase plasminogen activator receptor and its soluble form in common biopsy-proven kidney diseases and in staging of diabetic nephropathy

“…uPAR may be shed from the cell surface by several protease as a soluble bioactive peptide in blood and body fluid, called soluble uPAR (suPAR), that has multiple biological properties [3]. Besides being associated with several cancers and metastasis [1], a large body of research shows that suPAR may be a valuable biomarker of sepsis, critical illness, and several inflammatory diseases for diagnosis and prognosis in a clinical setting [4][5][6]. Moreover, some studies indicated that suPAR is associated with cardiovascular disease, diabetes mellitus (DM) and the process of atherosclerosis.…”

Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion*

“…suPAR has been identified as a plasma biomarker of pneumonia and sepsis (14), HIV (15), rheumatoid arthritis (16), cir-rhosis (17), and atherosclerotic disease (18). suPAR also has been identified as a plasma biomarker of multiple forms of cancer (19 -26).…”

Diagnostic Value of 25-Hydroxyvitamin D Level and New Cytokines in Neonatal Sepsis

“…Wiersinga et al showed that uPAR has a critical role against sepsis in the immune system by facilitating the migration of neutrophils toward the primary area of infection and subsequently facilitating phagocytosis (22). Savva et al found that concentrations of suPAR in supernatants of neutrophils of patients with sepsis were greater compared to controls and concluded that suPAR is a reliable marker of sepsis and sepsis severity (23). Florguin et al found high uPAR levesl in the urinary tract during urosepsis and experimental endotoxemia and concluded that systemic and renal production of uPAR during urosepsis may play an important role in eliminating the infection and protecting renal function (24).…”