Soluble urokinase plasminogen activator receptor in plasma of patients with inflammatory rheumatic disorders: increased concentrations in rheumatoid arthritis

Slot, Ole; Brünner, Nils; Locht, Henning; Oxholm, P; Stephens, Ross W.

doi:10.1136/ard.58.8.488

Cited by 128 publications

(114 citation statements)

References 21 publications

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“…Many cytokines and routine laboratory measures were associated with suPAR (Table 2). Convincing correlations between suPAR and the proinflammatory cytokines IL-1 and TNF as well as CRP and creatinine have been shown also in other conditions, 29,[41][42][43] and could be expected since uPAR is up-regulated and shed from immune cells during inflammation. Interestingly, suPAR levels were not inversely associated with complement proteins or complement function, which further demonstrates a lack of apparent association between suPAR and disease activity in lupus.…”

Section: Discussionmentioning

confidence: 99%

“…16 Many cell types express uPAR (CD87), including vascular smooth muscle cells, 17 16,27 In the first studies on circulating suPAR, levels were found to be elevated and to predict disease outcome in various forms of cancer and infectious diseases. 16,28 It has also been suggested to be a biomarker of value in rheumatoid arthritis, 29 and to reflect organ damage in liver and kidney disease. [30][31][32] The aims of the present study were to investigate if circulating suPAR reflects inflammatory activity and/or organ damage in lupus.…”

Section: Introductionmentioning

confidence: 99%

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Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Enocsson

Wetterö

Skogh

et al. 2013

Translational Research

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Compared to healthy controls, serum suPAR levels were significantly elevated in SLE patients. No association was recorded regarding suPAR levels and SLE disease activity in cross-sectional or consecutive samples. However, a strong association was observed between suPAR and SDI (p<0.0005). Considering distinct SDI domains, renal, neuropsychiatric, ocular, skin and peripheral vascular damage had significant impact on suPAR levels.This study is the first to demonstrate an association between serum suPAR and irreversible organ damage in SLE. Further studies are warranted to evaluate suPAR and other biomarkers as predictors of evolving organ damage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Enocsson

Wetterö

Skogh

et al. 2013

Translational Research

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“…Furthermore, in their study suPAR levels in RA were positively correlated to CRP and ESR values. They concluded that increased suPAR levels might reflect erosive activity in RA [14] . It is of interest that we also found a correlation between ESR and DAS28 but not CRP values and suPAR levels investigating all RA patients ( Figure 1A, B).…”

Section: Discussionmentioning

confidence: 99%

Soluble urokinase plasminogen activator receptor (suPAR) in the assessment of inflammatory activity of rheumatoid arthritis patients in remission

Toldi

Bekő

Kádár

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the assessment of systemic inflammation. We aimed to evaluate suPAR for the assessment of inflammatory activity in rheumatoid arthritis (RA) patients in remission. Methods: In our cross-sectional study we measured plasma suPAR and C-reactive protein (CRP) levels as well as erythrocyte sedimentation rate (ESR) in 120 RA patients at various stages of disease activity and 29 healthy agematched controls. Results: suPAR, CRP and ESR values were higher in RA patients compared to healthy individuals. When suPAR levels were analyzed according to DAS28 scores of RA patients, suPAR level in the subgroup with DAS28 ≤ 2.6 was lower than in the subgroup with DAS28 > 2.6, but still higher than in controls [4.45 (3.33 -5.56) ng/mL vs. 3.66 (3.10 -4.67) ng/mL vs. 2.80 (2.06 -3.42) ng/mL, p < 0.0001, median (interquartile range)]. In contrast, CRP and ESR values were comparable in the subgroup with DAS28 ≤ 2.6 and in healthy individuals. We further analyzed the correlation between the number of tender and/or swollen joints and suPAR levels in RA patients in remission. suPAR values were significantly higher in patients with four tender and/or swollen joints than in patients with 2 -3 or 0 -1 tender and/or swollen joints. Conclusions: While CRP and ESR values indicate remission of the chronic inflammatory process in RA, suPAR values are still elevated compared to healthy individuals. suPAR might be particularly valuable in the recognition of inflammatory activity in patients who are in remission according to DAS28 scores but have symptoms of tender and/or swollen joints.

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“…These include trauma, surgery, burns, tissue necrosis, immunologically mediated inflammatory diseases, crystal-induced inflammatory diseases, and advanced cancer (12). Same as CRP, increase of suPAR was also reported in the absence of infection in rheumatoid arthritis (5), and virtually in all human cancers, suggesting its possible clinical applications as diagnostic marker, predictive tool of survival or clinical response, and as a target for therapy and imaging (16)(17)(18). However, we recognized that our study also had limitations.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Sepsis

Barati

Shekarabi

Chobkar

et al. 2014

Arch Clin Infect Dis

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Background: Sepsis is one of the most important causes of morbidity and mortality in the intensive care units (ICUs). It is difficult to accurately differentiate sepsis from similar diseases rapidly. Therefore, it becomes critical to identify any biomarker with the ability of differentiation between sepsis and nonsepsis conditions. The urokinase plasminogen activator receptor has been implicated as an important factor in regulation of leukocyte adhesion and migration. Objectives: In this study, we evaluated the value of soluble urokinase plasminogen activator receptor (suPAR), erythrocyte sedimentation (ESR), and C-reactive protein (CRP) serum levels in terms of their value for sepsis diagnosis in ICU patients. Patients and Methods:We enrolled 107 ICU patients; 40 with sepsis, 43 with systemic inflammatory response syndrome, and 24 as control group. Serum soluble urokinase plasminogen activator receptor, ESR, white blood cell (WBC), and CRP levels were measured on the day of admission. Results: The group with sepsis had higher suPAR, ESR, and CRP levels compared with the group with noninfectious systemic inflammatory response syndrome (SIRS) (P = 0.01, 0.00 and 0.00, respectively). CRP concentrations and ESR were higher in the sepsis group than in the non-SIRS group (P = 0.00 and 0.00, respectively). In a receiver-operating characteristic curve analysis, ESR, CRP and suPAR had an area under the curve larger than 0.65 (P = 0.00) in distinguishing between septic and noninfectious SIRS patients. CRP, ESR and suPAR had a sensitivity of 87%, 71% and 66% and a specificity of 59%, 76% and 74% respectively in diagnosing infection in SIRS. Conclusions:The diagnostic values of CRP and ESR were better than suPAR and WBC count in patients with sepsis.

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Soluble urokinase plasminogen activator receptor in plasma of patients with inflammatory rheumatic disorders: increased concentrations in rheumatoid arthritis

Cited by 128 publications

References 21 publications

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Soluble urokinase plasminogen activator receptor (suPAR) in the assessment of inflammatory activity of rheumatoid arthritis patients in remission

Evaluation of Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Sepsis

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