Soluble triggering receptor expressed on myeloid cells (sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease

Koussoulas, Vassilios; Vassiliou, Spyridon; Demonakou, Maria; Tassias, G; Giamarellos‐Bourboulis, Evangelos J.; Mouktaroudi, Maria; Giamarellou, Helen; Barbatzas, Charalambos

doi:10.1097/00042737-200604000-00010

Cited by 41 publications

(27 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[10][11][12] Among the critically ill patients analyzed in these studies, the determination of sTREM-1 proved to be a useful and highly sensitive parameter for accurate diagnosis. Further studies where sTREM-1 is detected in patients with chronic obstructive pulmonary disease, 13 peptic ulcer disease, 14 or inflammatory bowel disease 15 confirm the involvement of TREM-1 also in noncritically ill patient collectives and suggest that the activation of TREM-1 plays a general role in the innate inflammatory response. 7 However, a deeper understanding of how TREM-1 influences inflammatory responses and sepsis requires the characterization of the natural ligand for TREM-1 and its expression pattern.…”

Section: Introductionmentioning

confidence: 75%

TREM-1 ligand expression on platelets enhances neutrophil activation

Haselmayer

Grosse‐Hovest

Landenberg

et al. 2007

Blood

176

152

View full text Add to dashboard Cite

IntroductionSepsis is a complex clinical condition caused by a dysregulated immune response to an infection oftentimes resulting in multiorgan failure with a fatal outcome. 1 Current concepts for the understanding of this dramatic clinical condition suggest that an overwhelming innate inflammatory response to a microbial infection associated with the release of factors such as IL-1, IL-6, TNF-␣, and others early on is involved. 2 Recently, the triggering receptor expressed on myeloid cells 1 (TREM-1) has been identified as an important receptor involved in the innate inflammatory response and in sepsis. [3][4][5][6] TREM-1 is a member of the v-type immunoglobulin super family and expressed on polymorphonuclear leukocytes (PMNs) and monocytes. 7 The expression of TREM-1 is up-regulated upon stimulation with microbial products, and receptor ligation activates the full repertoire of PMN effector functions such as the respiratory burst, phagocytosis, release of IL-8, and myeloperoxidase in synergy with Toll-like receptor (TLR) ligands such as LPS or bacterial lipopeptides. 3,6,8,9 The importance of TREM-1 in the innate inflammatory response is underlined in mouse models for sepsis where the administration of a recombinant soluble TREM-1 fusion protein or a conserved TREM-1 peptide can save the animals from a lethal endotoxic shock or microbial sepsis induced by cecal ligation and puncture. 5,6 The clinical significance of the TREM-1 system is further emphasized by reports that a soluble form of TREM-1 (sTREM-1) is released and detectable in the bronchoalveolar lavage fluid or serum in patients with ventilator-associated pneumonia or sepsis, respectively. 10-12 Among the critically ill patients analyzed in these studies, the determination of sTREM-1 proved to be a useful and highly sensitive parameter for accurate diagnosis. Further studies where sTREM-1 is detected in patients with chronic obstructive pulmonary disease, 13 peptic ulcer disease, 14 or inflammatory bowel disease 15 confirm the involvement of TREM-1 also in noncritically ill patient collectives and suggest that the activation of TREM-1 plays a general role in the innate inflammatory response. 7 However, a deeper understanding of how TREM-1 influences inflammatory responses and sepsis requires the characterization of the natural ligand for TREM-1 and its expression pattern. 7 To this end, we provide evidence that the natural ligand for TREM-1 is present on human platelets. We demonstrate specific binding of recombinant soluble TREM-1 (rsTREM-1) on human platelets. In addition, we show that coincubation of PMNs with platelets in the presence of microbial LPS enhances the neutrophil respiratory burst and release of IL-8 as primary PMN effector functions in a TREM-1-specific manner. Taken together, our results indicate a yet-unrecognized interaction between PMNs and platelets during innate the inflammatory response that is mediated by TREM-1 and its ligand. Materials and methods MaterialsLipopolysaccharide (LPS) from Salmonella typhimurium was obtained fro...

show abstract

Section: Introductionmentioning

confidence: 75%

TREM-1 ligand expression on platelets enhances neutrophil activation

Haselmayer

Grosse‐Hovest

Landenberg

et al. 2007

Blood

176

152

View full text Add to dashboard Cite

show abstract

“…TREM-1 expression is increased during both acute ( 49,50 ) and chronic infl ammation ( 51 ). Moreover, a soluble form of TREM-1 was detected in the blood sample of human patients with infl ammatory disorders, such as sepsis ( 52 ), pneumonia ( 53 ), acute pancreatitis ( 54 ), and peptic ulcer disease ( 55 ). Very recently, Kuai et al reported that TREM-1 expression is increased in the synovium of RA patients ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines

Chang

Sardella

Chun

et al. 2011

Journal of Lipid Research

View full text Add to dashboard Cite

“…Moreover, the presence of elevated levels of sTREM-1 in bronchoalveolar lavage fluid is a strong predictor of pneumonia [12]. sTREM-1 is also elevated in the gastric juice of patients with gastritis, showing positive correlation with the degree of gastric inflammation scores [13]. Recently, it was reported that TREM-1 expression is involved in chronic IBD based on the observation that TREM-1 is upregulated in the intestine of patients with IBD [14].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

et al. 2008

View full text Add to dashboard Cite

Although triggering receptor expressed on myeloid cells-1 (TREM-1) has recently been shown to be upregulated in the intestines of patients with inflammatory bowel disease (IBD), it remains unclear whether serum-soluble TREM-1 (sTREM-1) level reflects disease activity in patients with IBD. This study aimed to evaluate the correlation of sTREM-1 level with disease activity in IBD. We prospectively enrolled consecutive patients with IBD and assessed their clinical disease activity using the guidelines of the American College of Gastroenterology. At the time that disease activity was assessed, sTREM-1 level (using an enzyme-linked immunosorbent assay method) and other laboratory findings including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured. A total of 31 patients with ulcerative colitis (UC) and 22 with Crohn's disease (CD) were enrolled. The mean sTREM-1 level in patients with either UC (60.4 +/- 41.8 pg/ml) or CD (66.5 +/- 42.4 pg/ml) was significantly higher than in healthy controls (0.6 +/- 1.4 pg/ml) (P = 0.003 and P = 0.002, respectively). In patients with UC, sTREM-1 level was more highly correlated with disease activity (r = 0.849) than was ESR (r = 0.619) or CRP level (r = 0.546). Moreover, sTREM-1 level correlated well with disease activity irrespective of disease extent. In patients with CD, sTREM-1 level was lower in those with remission compared with those without (46.8 +/- 35.3 pg/ml versus 77.8 +/- 43.1 pg/ml), but this trend did not reach statistical significance (P = 0.100). The results of our study suggest that sTREM-1 could be a potential marker for disease activity in IBD patients, especially those with UC.

show abstract

Soluble triggering receptor expressed on myeloid cells (sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease

Abstract: sTREM-1 might be an independent factor involving with the peptic ulcerative inflammatory process that is positively correlated with histopathological abnormalities of gastritis.

Cited by 41 publications

References 14 publications

TREM-1 ligand expression on platelets enhances neutrophil activation

TREM-1 ligand expression on platelets enhances neutrophil activation

TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines

Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

Contact Info

Product

Resources

About