Soluble TREM‐1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis

Abstract

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The relationship between vitamin D receptor gene and TREM‐1 gene polymorphisms and the susceptibility and prognosis of neonatal sepsis

“…Triggering receptor expressed on myeloid cells 1 is a member of the immunoglobulin superfamily associated with inflammation that has been discovered in recent years. 26 Its soluble form, sTREM‐1 is often used in clinical diagnosis and condition judgment of various infectious diseases. 27 , 28 , 29 After the body is infected, TREM‐1 falls off as the expression increases on the surface of activated neutrophils or macrophages, 26 so sTREM‐1 can be detected in body fluids.…”

“… 26 Its soluble form, sTREM‐1 is often used in clinical diagnosis and condition judgment of various infectious diseases. 27 , 28 , 29 After the body is infected, TREM‐1 falls off as the expression increases on the surface of activated neutrophils or macrophages, 26 so sTREM‐1 can be detected in body fluids. During the infection process, sTREM‐1 can be released into body fluids and is closely related to the severity of the infection, especially in patients with sepsis and bronchial bubble lavage fluid of patients with pneumonia, sTREM‐1 is significantly increased.…”

“…Triggering receptor expressed on myeloid cells 1 is a member of the immunoglobulin superfamily associated with inflammation that has been discovered in recent years 26 . Its soluble form, sTREM‐1 is often used in clinical diagnosis and condition judgment of various infectious diseases 27–29 .…”

“…The subjects of this study were neonates, whose immunity was lower than that of adults. When vitamin D was insufficient or deficient, infections and sepsis were more likely to occur.Triggering receptor expressed on myeloid cells 1 is a member of the immunoglobulin superfamily associated with inflammation that has been discovered in recent years 26. Its soluble form, sTREM-1 is often used in clinical diagnosis and condition judgment of various infectious diseases [27][28][29].…”

Small-molecule natural products for reversing liver fibrosis based on modulation of HSCs activation: an update

“…Through creating a positive feedback loop with TGF-β-Smad2/3 pathway, nesting plays an important pro-fibrotic role in LF, providing a possible curative target to LF therapy [46] . A novel ligand of Robo2, STREM-1, can bind to Robo2 to launch downstream Smad2/3 as well as PI3K/Akt signaling, resulting in facilitating HSCs stimulation [47] . Retinoic acid (RA) is required to maintain elevated expression of α-SMA as well as type I collagen in stimulated HSCs.…”