Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis

Spahr, Laurent; Giostra, Emile; Frossard, Jean‐Louis; Bresson‐Hadni, Solange; Rubbia‐Brandt, Laura; Hadengue, Antoine

doi:10.1016/j.jhep.2004.04.028

Cited by 59 publications

(33 citation statements)

References 40 publications

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“…These observations are in line with 2 recent studies that also highlighted the predictive value of sTNF-R 75 levels as an independent risk factor for cirrhotic patients. 42,43 However, these studies were either focused on short-term survival (3 months) or did not evaluate the value of sTNF-Rs in comparison with MELD. 42,43 Furthermore, we made some additional observations.…”

Section: Discussionmentioning

confidence: 99%

Elevated Soluble Tumor Necrosis Factor Receptor 75 Concentrations Identify Patients With Liver Cirrhosis at Risk of Death

Grünhage¹,

Rezori²,

Neef³

et al. 2008

Clinical Gastroenterology and Hepatology

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Section: Discussionmentioning

confidence: 99%

Elevated Soluble Tumor Necrosis Factor Receptor 75 Concentrations Identify Patients With Liver Cirrhosis at Risk of Death

Grünhage¹,

Rezori²,

Neef³

et al. 2008

Clinical Gastroenterology and Hepatology

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“…Serum level of cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6 and IL-8 are elevated in acute alcoholic hepatitis [8] . Studies have shown a linear relationship between TNF-α receptors and mortality from acute alcoholic hepatitis [9] . Maddrey discriminant function (DF) has commonly been used in estimating mortality among patients with acute alcoholic hepatitis, with an elevated DF (> 32) indicating an increased likelihood of death, and conversely, a low DF suggesting a generally favorable prognosis [10,11] .…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline versus prednisolone for severe alcoholic hepatitis: A randomized controlled trial

De¹,

Gangopadhyay²,

Dutta³

et al. 2009

WJG

134

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AIM:To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis, and to evaluate the role of different liver function scores in predicting prognosis. METHODS:Sixty-eight patients with severe alcoholic hepatitis (Maddrey score ≥ 32) received pentoxifylline (n = 34, group Ⅰ) or prednisolone (n = 34, group Ⅱ) for 28 d in a randomized double-blind controlled study, and subsequently in an open study (with a tapering dose of prednisolone) for a total of 3 mo, and were followed up over a period of 12 mo. RESULTS:Twelve patients in group Ⅱ died at the end of 3 mo in contrast to five patients in group Ⅰ. The probability of dying at the end of 3 mo was higher in group Ⅱ as compared to group Ⅰ (35.29% vs 14.71%, P = 0.04; log rank test). Six patients in group Ⅱ developed hepatorenal syndrome as compared to none in group Ⅰ. Pentoxifylline was associated with a significantly lower model for end-stage liver disease (MELD) score at the end of 28 d of therapy (15.53 ± 3.63 vs 17.78 ± 4.56, P = 0.04). Higher baseline Maddrey score was associated with increased mortality. CONCLUSION:Reduced mortality, improved risk-benefit profile and renoprotective effects of pentoxifylline compared with prednisolone suggest that pentoxifylline is superior to prednisolone for treatment of severe alcoholic hepatitis.

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“…Studies on sera of patient with alcoholic steatohepatitis demonstrate increased circulating levels of Fas, FasL, and TNF-␣. TNF-␣ levels correlate with mortality in these patients [55,56]. Hepatocyte apoptosis also correlates with the Maddrey score, a prognostic indicator in acute alcoholic hepatitis.…”

Section: Alcohol-related Liver Diseasementioning

confidence: 89%

Mechanisms of Liver Injury

Malhi

Gores

2011

Schiff's Diseases of the Liver

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Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis

Cited by 59 publications

References 40 publications

Elevated Soluble Tumor Necrosis Factor Receptor 75 Concentrations Identify Patients With Liver Cirrhosis at Risk of Death

Elevated Soluble Tumor Necrosis Factor Receptor 75 Concentrations Identify Patients With Liver Cirrhosis at Risk of Death

Pentoxifylline versus prednisolone for severe alcoholic hepatitis: A randomized controlled trial

Mechanisms of Liver Injury

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