Soluble tissue factor as predictor of future events in patients with acute myocardial infarction

Seljeflot, Ingebjørg; Hurlen, Mette; Hole, Torstein; Arnesen, Harald

doi:10.1016/j.thromres.2003.09.019

Cited by 37 publications

(27 citation statements)

References 15 publications

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“…The analysis of FVII and TF antigen reflects total FVII, both zymogene and activated forms, and total TF, both membranebound and soluble forms. Although we are well aware that the various FVII and TF forms could play different roles in thrombus formation, we assumed, in accordance with other authors, 10,21 that elevation of FVII and TF antigen reflects their procoagulant activity. Recently, it has been suggested that the TF determination with a commercially available immunoassay is not satisfactory.…”

Section: Study Limitationssupporting

confidence: 78%

“…Recently, it has been suggested that the TF determination with a commercially available immunoassay is not satisfactory. 19,22 Nevertheless, this immunoassay has been extensively used in previous studies 10,19 and our data are in the range of values obtained with the new improved assay. 22 The sample size of our study was too small to allow an affordable estimate of predictive role of gene polymorphisms.…”

Section: Study Limitationsmentioning

confidence: 57%

“…Moreover, although previous studies investigated the association between different hemostatic factors and the occurrence of coronary events, [5][6][7][8][9][10] it remains unclear whether TF and FVII levels, measured in patients with MI soon after symptoms onset, may carry valuable prognostic information.…”

Section: Discussionmentioning

confidence: 99%

“…9 Moreover, in a sub-study of the WARIS-II trial, involving patients with myocardial infarction (MI), increased levels of TF, measured 5 to 7 days after the acute event, were independently associated to the occurrence of future clinical events. 10 The role of admission FVII and TF levels in patients with acute MI, however, has been less extensively studied. In particular, very limited data are available regarding the prognostic influence of FVII and TF levels at entry in patients admitted for acute MI.…”

mentioning

confidence: 99%

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Tissue Factor and Coagulation Factor VII Levels During Acute Myocardial Infarction

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Valgimigli

Ferraresi

et al. 2006

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Objective-We investigated in patients with ongoing myocardial infarction (MI) whether coagulation factor VII (FVII) and tissue factor (TF) levels are affected at admission by genetic components and whether they may predict subsequent cardiovascular events. Methods and Results-256 patients admitted for MI were evaluated for FVII and TF antigen levels before any treatment at entry, and were genotyped for FVII and TF polymorphisms. FVII gene insertions at Ϫ323, 11293 and the Ϫ402G/A change predicted FVII levels and explained 14% of variance. The Ϫ603 TF gene polymorphism failed to affect significantly TF levels (Pϭ0.07). These variables were correlated with the incidence of death (36 patients) and reinfarction (9 patients) after a median follow-up of 397 days. Events were independently predicted by FVII (HR 2.1, 95% CI 1.2 to 5.7) and TF (HR 4.1, 95% CI 2 to 11) levels. Composite end point was significantly worse when both parameters were above the receiver-operating characteristics (ROC) values (HR 8.3, 95% CI 5 to 18, compared with FVII and TF below), and above the ROC value of TF (Ͼ630 pg/mL) it differed among FVII genotype groups. Conclusions-Admission

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Section: Study Limitationssupporting

confidence: 78%

Section: Study Limitationsmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Tissue Factor and Coagulation Factor VII Levels During Acute Myocardial Infarction

Campo

Valgimigli

Ferraresi

et al. 2006

ATVB

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show abstract

“…[25][26][27][28][29][30][31] Some studies show a correlation between the levels of blood-borne TF and acute myocardial infarction. 25,32,33 Nemerson et al demonstrated that blood-borne TF in human blood supported clot formation in vitro. 34 In addition, inhibition of TF in a rabbit model of venous thrombosis reduced thrombus propagation.…”

Section: Role Of Tf In Thrombosismentioning

confidence: 99%