Soluble Tie‐2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma

Homer, Jarrod J; Greenman, John; Drevs, Joachim; Marmé, Dieter; Stafford, Nicholas D.

doi:10.1002/hed.10123

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…sTie-2 has been identified in supernatants from cultured endothelial cells, is present in normal human serum and plasma [37], and has been identified as a biomarker in cancer [38-40], sepsis [41], and ischemia [42]. It is shed from endothelial cells as a result of ectodomain cleavage by matrix metalloproteinases [43], and this cleavage can be stimulated by a variety of physiological factors, including basic fibroblast growth factor and vascular endothelial growth factor [37, 42, 44].…”

Section: Discussionmentioning

confidence: 99%

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

Conroy

Glover

Hawkes

et al. 2012

Critical Care Medicine

100

114

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Objective To investigate the relationship between the angiopoietin-Tie-2 system, retinopathy and mortality in children with cerebral malaria (CM). Design Case-control study of retinopathy positive versus retinopathy negative children with clinically defined CM. Setting Queen Elizabeth Central Hospital in Blantyre, Malawi. Subjects 155 children presenting with severe malaria and meeting a strict definition of clinical cerebral malaria (Blantyre Coma Score ≤2, Plasmodium falciparum parasitemia, no other identifiable cause for coma) were included in the study. Measurements Clinical and laboratory parameters were recorded at admission and fundoscopic exams were performed. Admission levels of angiopoietin-1, angiopoietin-2 and a soluble version of their cognate receptor (sTie-2) were measured by ELISA. Main results We show that angiopoietin-1 levels are decreased and angiopoietin-2 and sTie-2 levels are increased in children with CM who had retinopathy compared to those who did not. Angiopoietin-2 and sTie-2 were independent predictors of retinopathy (adjusted Odds ratio (95% CI): angiopoietin-2, 4.3 (1.3-14.6), p=0.019; sTie-2, 9.7 (2.1-45.8), p=0.004). Angiopoietin-2 and sTie-2 were positively correlated with the number of hemorrhages, the severity of retinal whitening and the extent of capillary whitening observed on fundoscopic exam (p<0.05 following adjustment for multiple comparisons). Angiopoietin-2 and sTie-2 levels were elevated in children with CM who subsequently died and Angiopoetin-2 was an independent predictor of death (adjusted Odds ratio: 3.9 (1.2-12.7), p=0.024). When combined with clinical parameters, Angiopoetin-2 improved prediction of mortality using logistic regression models and classification trees. Conclusions These results provide insights into mechanisms of endothelial activation in CM and indicate that the angiopoietin-Tie-2 axis is associated with retinopathy and mortality in pediatric CM.

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Section: Discussionmentioning

confidence: 99%

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

Conroy

Glover

Hawkes

et al. 2012

Critical Care Medicine

100

114

View full text Add to dashboard Cite

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“…A few circulating tumor markers such as endostatin, angiogenin, Tie-2 receptor and anti-p53-antibody have been investigated as prognostic indicators among HNSCC patients. [33][34][35] None of them, however, has been accepted as a routine clinical marker.…”

Section: Discussionmentioning

confidence: 99%

Serum matrix metalloproteinase‐9 in head and neck squamous cell carcinomais a prognostic marker

Ruokolainen

Pääkkö

Turpeenniemi‐Hujanen

2005

Intl Journal of Cancer

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The aim of this study was to determine whether serum matrix metalloproteinase-9 (MMP-9) could predict cause-specific and relapse-free survival in patients with squamous cell carcinoma of head and neck. Furthermore, this study was designed to investigate whether there is an association between MMP-9 immunohistochemical staining and serum MMP-9 levels. Pretreatment serum levels of MMP-9 were quantitatively measured by ELISA assay in 67 patients presenting with a primary head and neck squamous cell carcinoma. The results were compared with the corresponding immunohistochemical staining results, clinical data and the patients' outcome. The follow-up time for all of the patients was at least 5 years. There was a statistically significant correlation between circulating MMP-9 and MMP-9 immunohistochemical staining in the corresponding tumors (p 5 0.028). The cause-specific and relapse-free survival rates were clearly lower among patients with high MMP-9 serum levels (> 73 ng/ml). The 5-year cause-specific survival-rate was 40% in a patient group with high serum MMP-9, and 69% for patients with a low MMP-9 level (p 5 0.027). In the same follow-up period, the cumulative relapsefree survival rate was 36% in patients presenting with a high serum MMP-9 and 66% in those with a low MMP-9 level. No correlation was found between MMP-9 serum levels and the traditional clinical or histopathologic factors. The results suggest for the first time that pretreatment serum MMP-9 level could serve as a prognostic factor in head and neck squamous cell carcinoma. ' 2005 Wiley-Liss, Inc.

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“…Tie-1 kinase expression inversely correlates with survival in gastric cancer [31] and in early chronic TEC family BMX -BTK -ITK -TEC -TXK -phase chronic myeloid leukaemia [32]. Soluble Tie-2 receptor levels independently predict loco-regional recurrence in head and neck squamous cell carcinoma [33]. ALK protein expression is an independent predictor of survival and serves as a useful biologic marker of a specific disease entity within the spectrum of anaplastic large cell lymphoma (ALCL) [34].…”

Section: Tyrosine Kinases and Human Cancermentioning

confidence: 99%

Tyrosine kinase inhibitors in cancer therapy

Madhusudan

Ganesan

2004

Clinical Biochemistry

202

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Soluble Tie‐2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma

Abstract: Soluble Tie2R is an independent predictor of locoregional recurrence in HNSCC.

Cited by 10 publications

References 25 publications

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

Serum matrix metalloproteinase‐9 in head and neck squamous cell carcinomais a prognostic marker

Tyrosine kinase inhibitors in cancer therapy

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