2002
DOI: 10.1002/hed.10123
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Soluble Tie‐2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma

Abstract: Soluble Tie2R is an independent predictor of locoregional recurrence in HNSCC.

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Cited by 10 publications
(8 citation statements)
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“…sTie-2 has been identified in supernatants from cultured endothelial cells, is present in normal human serum and plasma [37], and has been identified as a biomarker in cancer [38-40], sepsis [41], and ischemia [42]. It is shed from endothelial cells as a result of ectodomain cleavage by matrix metalloproteinases [43], and this cleavage can be stimulated by a variety of physiological factors, including basic fibroblast growth factor and vascular endothelial growth factor [37, 42, 44].…”
Section: Discussionmentioning
confidence: 99%
“…sTie-2 has been identified in supernatants from cultured endothelial cells, is present in normal human serum and plasma [37], and has been identified as a biomarker in cancer [38-40], sepsis [41], and ischemia [42]. It is shed from endothelial cells as a result of ectodomain cleavage by matrix metalloproteinases [43], and this cleavage can be stimulated by a variety of physiological factors, including basic fibroblast growth factor and vascular endothelial growth factor [37, 42, 44].…”
Section: Discussionmentioning
confidence: 99%
“…A few circulating tumor markers such as endostatin, angiogenin, Tie-2 receptor and anti-p53-antibody have been investigated as prognostic indicators among HNSCC patients. [33][34][35] None of them, however, has been accepted as a routine clinical marker.…”
Section: Discussionmentioning
confidence: 99%
“…Tie-1 kinase expression inversely correlates with survival in gastric cancer [31] and in early chronic TEC family BMX -BTK -ITK -TEC -TXK -phase chronic myeloid leukaemia [32]. Soluble Tie-2 receptor levels independently predict loco-regional recurrence in head and neck squamous cell carcinoma [33]. ALK protein expression is an independent predictor of survival and serves as a useful biologic marker of a specific disease entity within the spectrum of anaplastic large cell lymphoma (ALCL) [34].…”
Section: Tyrosine Kinases and Human Cancermentioning
confidence: 99%