Soluble thrombomodulin attenuates sinusoidal obstruction syndrome in rat through suppression of high mobility group box 1

Nakamura, Kojiro; Hatano, Etsuro; Miyagawa‐Hayashino, Aya; Okuno, Masayuki; Koyama, Yukinori; Narita, Michiko; Seo, Satoru; Taura, Kojiro; Üemoto, Shinji

doi:10.1111/liv.12420

Cited by 30 publications

(32 citation statements)

References 46 publications

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“…• HMGB1 acts as a mediator playing a key role both in the early and late stages of systemic inflammation and its acetylated form may be a better biomarker for prognosis prediction in DILI. Wang et al, 2013;Nakamura et al, 2014;Huebener et al, 2015;Lundback et al, 2016 FABP1 • Abundant in liver and weak expression in heart and skeletal muscles.…”

Section: High Mobility Group Box-1 Protein (Hmgb1)mentioning

confidence: 99%

Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

Jiang

et al. 2020

Front. Pharmacol.

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Drug-induced liver injury (DILI) is one among the common adverse drug reactions and the leading causes of drug development attritions, black box warnings, and post-marketing withdrawals. Despite having relatively low clinical incidence, its potentially severe adverse events should be considered in the individual patients due to the high risk of acute liver failure. Although traditional liver parameters have been applied to the diagnosis of DILI, the lack of specific and sensitive biomarkers poses a major limitation, and thus accurate prediction of the subsequent clinical course remains a significant challenge. These drawbacks prompt the investigation and discovery of more effective biomarkers, which could lead to early detection of DILI, and improve its diagnosis and prognosis. Novel promising biomarkers include glutamate dehydrogenase, keratin 18, sorbitol dehydrogenase, glutathione S-transferase, bile acids, cytochrome P450, osteopontin, high mobility group box-1 protein, fatty acid binding protein 1, cadherin 5, miR-122, genetic testing, and omics technologies, among others. Furthermore, several clinical scoring systems have gradually emerged for the diagnosis of DILI including the Roussel Uclaf Causality Assessment Method (RUCAM), Clinical Diagnostic Scale (CDS), and Digestive Disease Week Japan (DDW-J) systems. However, currently their predictive value is limited with certain inherent deficiencies. Thus, perhaps the greatest benefit would be achieved by simultaneously combining the scoring systems and those biomarkers. Herein, we summarized the recent research progress on molecular biomarkers for DILI to improved approaches for its diagnosis and clinical management.

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Section: High Mobility Group Box-1 Protein (Hmgb1)mentioning

confidence: 99%

Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

Jiang

et al. 2020

Front. Pharmacol.

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“…The treatment protocol followed the rat SOS model with some modifications. 20 Briefly, MCT (200 mg per kg body weight) was administered to mice via IP injection on day 1 to induce SOS. Concurrently, either TME5 (1 mg per kg body weight, n = 6) or control diluent (double distilled water, n = 6) was administered to these mice via IP injection on days 1 and 2.…”

Section: Sos Murine Modelmentioning

confidence: 99%

“…20 They demonstrated that administration of MCT to rats increases serum levels of HMGB1 and non-histone nuclear proteins, and that rTM effectively counteracts the MCT-mediated increase in levels of HMGB1. HMGB1 is released from necrotic cells as well as activated inflammatory cells and stimulates further production of inflammatory cytokines in association with activation of NF-κB.…”

Section: Endothelial Syndromementioning

confidence: 99%

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The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model

Ikezoe

Yang

Nishioka

et al. 2016

Bone Marrow Transplant

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The present study found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C-independent manner in human umbilical vein endothelial cells (HUVECs). Importantly, TME5 counteracted calcineurin inhibitor-induced vascular permeability and successfully prevented monocrotaline-induced sinusoidal obstruction syndrome (SOS) in a murine model. Taken together, TME5 may be useful for preventing or treating lethal complications that develop after hematopoietic stem cell transplantation such as SOS and thrombotic microangiopathy in which endothelial cell damage has a role.

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“…Over the last years, evidence from animal experiments is emerging that ART‐123 has important organ protective effects and that it has cytoprotective effects on the endothelium . In a rodent model of hepatic warm ischemia, livers that were ex vivo perfused with ART‐123, after 6 hours of static cold preservation, showed significantly improved bile production and decreased sinusoidal narrowing compared with controls .…”

mentioning

confidence: 99%

Plasma From Patients Undergoing Liver Transplantation Is Resistant to Anticoagulant Activity of Soluble Thrombomodulin

et al. 2019

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Soluble thrombomodulin attenuates sinusoidal obstruction syndrome in rat through suppression of high mobility group box 1

Abstract: rTM preserved SECs and attenuated MCT-induced SOS in rats through suppression of circulatory HMGB1 and neutrophil accumulation, resulting in improved survival after hepatectomy.

Cited by 30 publications

References 46 publications

Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model

Plasma From Patients Undergoing Liver Transplantation Is Resistant to Anticoagulant Activity of Soluble Thrombomodulin

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