Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome

Abstract

Background: Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is an attractive and druggable molecule that sits at the interface between inflammation, oxidative stress and fibrosis. This study aims to analyze the relationship among sST2, oxidative stress, inflammation and echocardiographic parameters in MS patients. Methods: Fifty-eight patients with MS were recruited and underwent physical, laboratory and transthoracic echocardiography examinations. Commercial ELISA and appropriate colorimetric assays were used to quantify serum levels of oxidative stress and inflammation markers and sST2. Results: Circulating sST2 was increased in MS patients and was significantly correlated with the oxidative stress markers nitrotyrosine and 8-hydroxy-2′-deoxyguanosine as well as with peroxide levels. The inflammatory parameters interleukin-6, intercellular adhesion molecule-1 and myeloperoxidase were positively correlated with sST2. Noteworthy, sST2 was positively correlated with left ventricular mass, filling pressures and pulmonary arterial pressures. Conclusion: Circulating levels of sST2 are associated with oxidative stress and inflammation burden and may underlie the pathological remodeling and dysfunction of the heart in MS patients. Our results suggest that sST2 elevation precedes diastolic dysfunction, emerging as an attractive biotarget in MS.

Association of NT-proBNP and sST2 with Left Ventricular Ejection Fraction and Oxidative Stress in Patients with Stable Dilated Cardiomyopathy

“…The sST2-related inflammatory cell recruitment may trigger oxidative stress, as demonstrated by the positive association with hydrogen peroxide. In the study by Zhang in HF patients, sST2 levels positively correlated with serum malondialdehyde, while they negatively correlated with the antioxidant superoxide dismutase activity, suggesting a role for elevated sST2 in enhanced redox status [74,75]. Matilla et al [76], using proteomics and immunodetection approaches, demonstrated that sST2 downregulated mitofusin-1 (MFN-1), a protein involved in mitochondrial fusion, in human cardiac fibroblasts.…”

“…Roy et al [74] reported that, among patients with metabolic syndrome, increased levels of circulating sST2 correlated positively with inflammatory markers: IL-6, osteopontin, ICAM-1, myeloperoxidase and a classical reactive oxygen species marker nitrotyrosine (NT-Tyr). Furthermore, the investigators demonstrated a correlation between oxidative stress markers like 8-hydroxy-2 ′ -deoxyguanosine (8-OHdG) and levels of hydrogen peroxide.…”

Estado del arte: Nuevos biomarcadores en el diagnóstico del Síndrome Metabólico

“…La implementación de paneles de biomarcadores junto con criterios de diagnóstico tradicionales puede mejorar la precisión diagnóstica y permitir un enfoque más personalizado en la prevención y manejo del síndrome metabólico. Sin embargo, se necesitan más estudios y validaciones en poblaciones diversas antes de su implementación clínica rutinaria (Roy et al, 2023).…”