Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis

Abstract

To assess the role of interleukin (IL)-33 and ST2, the receptor for IL-33, in the pathogenesis of systemic juvenile idiopathic arthritis (s-JIA), we sequentially measured the serum levels of IL-33 and soluble ST2 (sST2) in patients with s-JIA and determined their correlation with measures of disease activity and severity. Twenty-four patients with s-JIA, 5 with rheumatoid factor positive polyarticular JIA (RF + poly-JIA), and 20 age-matched healthy controls (HCs) were analyzed. IL-33 and sST2 levels were quantified in serum by enzyme-linked immunosorbent assays. Serum IL-33 levels in most patients with active s-JIA were below the lowest detection limit. Serum IL-33 levels in patients with RF + poly-JIA were significantly higher than those in patients with s-JIA and HC. Serum sST2 levels in patients during the active phase of s-JIA were much higher than those in patients with poly-JIA and HC. Serum sST2 levels in patients with s-JIA were significantly elevated even in the inactive phase, when other clinical parameters were normalized. Serum sST2 levels correlated positively with the clinical parameters of disease activity. These findings indicate that ST2 may be an important mediator in s-JIA. Serum sST2 levels in patients with s-JIA correlated with disease activity, suggesting a potential role as a promising indicator of disease activity.

The Interleukin 33/ST2 Axis in Patients with Primary Sjögren Syndrome: Expression in Serum and Salivary Glands, and the Clinical Association

“…However, we had some different observations in our study. According to previous research, sST2 levels correspond with the disease activity of autoimmune disorders 13,14,15,27 . This discrepancy might be attributed to the differences in the study population.…”

“…The on December 23, 2014 -Published by www.jrheum.org Downloaded from possibility of a potential biomarker 12,13,14,15,16 . The pathophysiological role of IL-33 has been demonstrated experimentally by the enhancement or elimination of IL-33/ST2 signaling in animal arthritis models 17,18 .…”

The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases

“…Serum sST2 levels are often elevated in inflammatory, infectious, or other disease situations. Circulating sST2 levels are in particular considered a prognostic biomarker in patients with cardiovascular disease [84] and juvenile idiopathic arthritis [85].…”

Elevated Levels of Soluble ST2 were Associated with Rheumatoid Arthritis Disease Activity and Ameliorated Inflammation in Synovial Fibroblasts

“…Another study found that soluble ST2 was correlated with disease activity in patients with systemic juvenile idiopathic arthritis. [ 15 ] We found that all patients in our follow-up who had a good response to the therapy had lower levels of soluble ST2 than at baseline. This result to a certain extent was consistent with a recent study[ 16 ] that utilized seven naïve RA patients and compared the soluble ST2 levels before and after treatment.…”