Soluble ST2 and troponin I combination: Useful biomarker for predicting development of stress cardiomyopathy in patients admitted to the medical intensive care unit

Yang, Hyun Suk; Shim, Hyoung Joon; Kim, Sun Jong; Hur, Mina; Somma, Salvatore Di

doi:10.1016/j.hrtlng.2015.04.010

Cited by 20 publications

(22 citation statements)

References 26 publications

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“…The median sST2 concentration was 110 [54.2-240.1] ng/mL, and most patients (118/127 patients, 92.9%) exhibited higher sST2 concentrations than the reference value (≤35 ng/mL) [8]. These results are consistent with our previous study on patients with stress cardiomyopathy in a non-cardiac medical intensive care unit; initial sST2 concentration did not predict stress cardiomyopathy, but the 48-hr follow-up sST2 concentration (persistently or newly increased sST2) did [16]. A limitation of our study is that we only performed a single sST2 measurement.…”

supporting

confidence: 89%

Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis

et al. 2016

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Soluble suppression of tumorigenicity 2 (sST2) has emerged as a biomarker of cardiac stretch or remodeling, and has demonstrated a role in acutely decompensated heart failure. However, its role in sepsis-induced cardiac dysfunction is still unknown. We explored whether sST2 serum concentration reflects either systolic or diastolic dysfunction as measured by Doppler echocardiography. In a total of 127 patients with sepsis, correlations between sST2 and blood pressure, left ventricular (LV) ejection fraction, LV diastolic filling (ratio of early transmitral flow velocity to early diastolic mitral annulus velocity), and resting pulmonary arterial pressure were evaluated. Correlations between sST2 and other sepsis biomarkers (high-sensitivity C-reactive protein [hs-CRP] and procalcitonin) were also examined. sST2 showed a moderate correlation with mean arterial pressure (r=-0.3499) but no correlation with LV ejection fraction, diastolic filling, or resting pulmonary hypertension. It showed moderate correlations with hs-CRP and procalcitonin (r=0.2608 and r=0.3829, respectively). sST2 might have a role as a biomarker of shock or inflammation, but it cannot reflect echocardiographic findings of LV ejection fraction or diastolic filling in sepsis.

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confidence: 89%

Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis

et al. 2016

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“…Several markers including Copeptin[13], lipid profile[14], sLOX-1[15], IMA[16], sST-2[17] have been proposed for differentiating TC from ACS. High HDL-C and lower levels of LDL and triglycerides have been reported in TC compared to MI[14].…”

Section: Laboratory Findingsmentioning

confidence: 99%

“…sLOX-1 elevation has been found comparable to troponin rise in ACS and is lower in non-ACS patients including TC[15]. Changes in level of sST2 have additional predictive value for TC in patients with normal Troponin I[17]. The most studied laboratory findings though are natriuretic peptides (NP), markers of cardiomyonecrosis (troponin I and T, creatine kinase and myoglobin) and catecholamines.…”

Section: Laboratory Findingsmentioning

confidence: 99%

Takotsubo cardiomyopathy: Pathophysiology and role of cardiac biomarkers in differential diagnosis

Gopalakrishnan

Zaidi

Sardar

2017

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Takotsubo cardiomyopathy (TC) is characterized by reversible ventricular dysfunction, not limited to the distribution of an epicardial coronary artery. A disease primarily afflicting post-menopausal women, it is frequently mistaken for acute anterior wall myocardial infarction. Alternatively called Stress Cardiomyopathy, physical or emotional triggers are identified in only three fourths of TC patients. Long considered a benign condition, recent findings suggest poor short term prognosis similar to acute coronary syndrome (ACS). Despite the widely recognized pathophysiological role of catecholamine excess, its diagnostic role is uncertain. TC is suspected based on typical wall motion abnormalities in ventriculogram or echocardiogram. Several additional electrocardiographic, laboratory and imaging parameters have been studied with the goal of clinical diagnosis of TC. While several clinical clues differentiate it from ACS, a clinical diagnosis is often elusive leading to avoidable cardiac catheterizations. Natriuretic peptides (NPs), a family of peptide hormones released primarily in response to myocardial stretch, play a significant role in pathophysiology, diagnosis as well as treatment of congestive heart failure. TC with its prominent ventricular dysfunction is associated with a significant elevation of NPs. NPs are elevated in ACS as well but the degree of elevation is typically lesser than in TC. Markers of myocardial injury such as troponin are usually elevated to a higher degree in ACS than in TC. This differential elevation of NPs and markers of myocardial injury may play a role in early clinical recognition of TC.

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“…8,[12][13][14] Furthermore, secondary TS carries a particularly poor prognosis. [16][17][18][19] After retrospectively identifying a TS population in a general, mixed ICU, we sought to (i) estimate the incidence of TS in hemodynamically unstable ICU-patients; (ii) identify predictors of TS in this population; (iii) study the impact of TS on prognosis and course of hospitalization. 8,9,[14][15][16][17][18] Despite the likely prognostic implications of TS in critical illness, TS in the ICU setting has not been sufficiently studied.…”

Section: Editorial Commentmentioning

confidence: 99%