Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

Zhu, Yinwei; Fang, Chongquan; Zhang, Qi; Lu, Yaling; Zhang, Rui; Wang, Aili; Bu, Xiaoqing; Zhang, Jintao; Ju, Zhong; Zhang, Yonghong; Xu, Tan; Zhong, Chongke

doi:10.1186/s12877-021-02288-6

Cited by 9 publications

(11 citation statements)

References 44 publications

(52 reference statements)

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“…The serum concentration of sST2 was significantly increased in patients with AD and MCI [ 2 , 47 ]. Elevated concentrations of plasma sST2 levels were significantly associated with cognitive impairment in acute ischemic stroke patients [ 142 , 143 ]. Elevated plasma levels of sST2 may contribute to neuronal injury and long-term neurocognitive impairment in older children with cerebral malaria [ 144 ].…”

Section: Discussionmentioning

confidence: 99%

Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation

et al. 2022

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With the advent of an aging society, the incidence of dementia is increasing, resulting in a vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated in various neurological diseases with cognitive dysfunction such as Alzheimer’s disease, multiple sclerosis, ischemic stroke, traumatic brain injury, and central nervous system infections. As an important neuroinflammatory factor, interleukin-33 (IL-33) is highly expressed in various tissues and cells in the mammalian brain, where it plays a role in the pathogenesis of a number of central nervous system conditions. Reams of previous studies have shown that IL-33 has both pro- and anti-inflammatory effects, playing dual roles in the progression of diseases linked to cognitive impairment by regulating the activation and polarization of immune cells, apoptosis, and synaptic plasticity. This article will summarize the current findings on the effects IL-33 exerts on cognitive function by regulating neuroinflammation, and attempt to explore possible therapeutic strategies for cognitive disorders based on the adverse and protective mechanisms of IL-33.

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Section: Discussionmentioning

confidence: 99%

Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation

et al. 2022

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“…Cognitive function was evaluated by experienced neurological physicians using the Chinese version of the Mini-Mental State Examination (MMSE) scale 3 months after lacunar infarction ( 21 ). The MMSE scale was widely used in cognitive function assessment in China ( 22 , 23 ). The total score of MMSE was 30, and the lower scores indicated the worse cognitive function.…”

Section: Methodsmentioning

confidence: 99%

“…Radiologic images were read by a radiologist and were reviewed by an experienced neurologist. (22,23). The total score of MMSE was 30, and the lower scores indicated the worse cognitive function.…”

Section: Lacunar Infarction Definitionmentioning

confidence: 97%

High serum amyloid A predicts risk of cognitive impairment after lacunar infarction: Development and validation of a nomogram

Pan

et al. 2022

Front. Neurol.

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BackgroundPost-stroke cognitive impairment (PSCI) after lacunar infarction was worth attention in recent years. An easy-to-use score model to predict the risk of PSCI was rare. This study aimed to explore the association between serum amyloid A (SAA) and cognitive impairment, and it also developed a nomogram for predicting the risk of PSCI in lacunar infarction patients.MethodsA total of 313 patients with lacunar infarction were enrolled in this retrospective study between January 2021 and December 2021. They were divided into a training set and a validation set at 70%:30% randomly. The Chinese version of the Mini-Mental State Examination (MMSE) was performed to identify cognitive impairment 3 months after discharge. Univariate and multivariate logistic regression analyses were used to determine the independent risk factors for PSCI in the training set. A nomogram was developed based on the five variables, and the calibration curve and the receiver operating characteristic (ROC) curve were drawn to assess the predictive ability of the nomogram between the training set and the validation set. The decision curve analysis (DCA) was also conducted in both sets.ResultsIn total, 52/313 (16.61%) participants were identified with PSCI. The SAA levels in patients with PSCI were significantly higher than non-PSCI patients in the training set (P < 0.001). After multivariate analysis, age, diabetes mellitus, white blood count, cystatin C, and SAA were independent risk predictors of PSCI. The nomogram demonstrated a good discrimination performance between the training set (AUC = 0.860) and the validation set (AUC = 0.811). The DCA showed that the nomogram had a well clinical utility in the two sets.ConclusionThe increased SAA is associated with PSCI in lacunar infarction patients, and the nomogram developed with SAA can increase prognostic information for the early detection of PSCI.

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“…The systematic search of online databases yielded 461 non-duplicate records, and 6 articles were acquired by a manual search. After evaluation, 19 articles were included in this systematic review [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Fig. 1), of which 10 investigated the value of serum sST-2 measurement in the prediction of the risk of stroke incidence [12][13][14][15][16][17][18][19][20][21], and the remaining 9 evaluated the value of serum sST-2 measurement in the prognosis of post-stroke outcomes [22][23][24][25][26][27][28][29][30].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…After evaluation, 19 articles were included in this systematic review [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Fig. 1), of which 10 investigated the value of serum sST-2 measurement in the prediction of the risk of stroke incidence [12][13][14][15][16][17][18][19][20][21], and the remaining 9 evaluated the value of serum sST-2 measurement in the prognosis of post-stroke outcomes [22][23][24][25][26][27][28][29][30]. A detailed description of the characteristics of these studies is provided in the respective sections.…”

Section: Study Characteristicsmentioning

confidence: 99%

Soluble Suppression of Tumorigenicity-2 as a Candidate Prognostic Marker for Stroke: A Systematic Review

et al. 2023

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Background: Risk stratification of patients for incidence of stroke and its outcomes can aid in decision-making regarding treatment options and rehabilitative care. We systematically reviewed the literature to provide comprehensive evidence for the value of serum soluble suppression of tumorigenicity-2 (sST-2) in the prediction of stroke incidence and the evaluation of post-stroke outcomes.Methods: The Medline, Scopus, Web of Science, and Embase databases were searched until the end of August 2022 for studies investigating the value of serum sST-2 in the prediction of stroke incidence and post-stroke outcomes.Results: Nineteen articles were included. The articles reported conflicting results on the predictive value of sST-2 measurement in the incidence of stroke. Studies investigating the value of sST-2 measurement for the prognosis of post-stroke outcomes have reported positive associations between sST-2 levels and post-stroke mortality, composite adverse events, major disability, cerebral-cardiac syndrome, and cognitive impairment. Conclusions:Although some studies have reported a predictive value of serum sST-2 measurement in the incidence of stroke, a clear consensus has yet to be reached because of discrepancies in the results. As for the prognosis of post-stroke outcomes, sST-2 may be a predictor of mortality, composite adverse events, and major disability after stroke. Overall, more well-designed prospective cohort studies are needed to reach a more decisive conclusion on the value of sST-2 measurement for the prediction of stroke and its outcomes and to determine optimal cutoffs.

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Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

Cited by 9 publications

References 44 publications

Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation

Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation

High serum amyloid A predicts risk of cognitive impairment after lacunar infarction: Development and validation of a nomogram

Soluble Suppression of Tumorigenicity-2 as a Candidate Prognostic Marker for Stroke: A Systematic Review

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