Soluble l‐Selectin as an Independent Biomarker of Bronchial Asthma

Abstract

Our study suggests that plasma level of sL-selectin is an independent biomarker for asthma.

Comparison of L‐selectin blood level and gene polymorphism in tuberculosis patients with healthy individuals

“…In this study, the Leu/Leu genotype was shown to be the least frequent genotype in the whole population. This result is similar to previous studies in the same population, which reported the Phe/Phe genotype as the major homozygote genotype …”

“…Our results showed significantly higher serum levels of L‐selectin in TB patients versus the healthy controls. In some studies, L‐selectin has been shown to be upregulated on immune cells in many infectious diseases and inflammatory responses; this finding is consistent with our results . Moreover, it has been shown that suppression of L‐selectin increases the risk of infection and can compromise cell‐mediated immune reactions .…”

“…Based on our results, the serum level of L‐selectin is higher in TB patients with Leu/Leu genotypes and healthy controls with Phe/Leu genotypes. This result is consistent with Nadi's study in a Hamadanian population with or without bronchial asthma . As few individuals carry the Phe/Phe genotype, a larger sample size may be required to identify the effect of Phe/Phe polymorphism on serum L‐selectin in TB patients.…”

“…Our study showed no significant relationship between specific allele frequency and TB. In contrast to our results, some studies have shown a significant relationship between Leu allele frequency and risk of brucellosis, coronary artery disease, or asthma . However, Sardarian showed no relationship between L‐selectin polymorphism and visceral leishmaniasis, which is more consistent with our results .…”

Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) based on microarray profiles of human joint fibroblast‐like synoviocytes

“…38 CCRs are the one category of protein receptors that could regulate cell activities of various types of leukocytes. 45 55 Some studies have also reported that SELE-mediated adhesion of leukocytes or tumour cells to the vascular endothelium was an important progress in the initiation of inflammatory response and metastasis of cancer cells. We therefore speculated that chemokine CCL5 In OA, we discovered that all genes in DEGsOA (coexpressed genes and OA-specific genes) were all playing the role of promoting inflammation progress by activating TNF signalling pathway.…”