Soluble resistance-related calcium-binding protein in cancers

Yu, Xiao; Murata, Jun; Mahmoud, Salma Abdi; Huang, He; Zhang, Qingqing; Zhang, Jun

doi:10.1016/j.cca.2018.08.034

Cited by 8 publications

(9 citation statements)

References 47 publications

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“…The Hca-F (lymph node metastasis > 75%) and Hca-P (lymph node metastasis < 25%) cell lines are subclones derived from the same parent cells of mouse hepatocarcinoma ascitic cells by our laboratory many years ago. Therefore, sharing the same genetic background, the two cell lines are ideal models for revealing potential biomarkers related to lymphatic metastasis [3,7,[11][12][13][14][15]. Previously, our laboratory used a gene chip technique to identify differentially expressed genes, and LEPR was more highly expressed in Hca-F cells than in Hca-P cells, which indicates that they are candidate genes for mouse hepatocarcinoma lymphatic metastasis [32].…”

Section: Discussionmentioning

confidence: 99%

“…In our laboratory, we found that the suppression of ANXA7 in Hca-F cells decreased proliferation, migration and invasion and increased the number of apoptotic cells. Many proteins have been reported to interact with ANXA7, such as ALG-2, SODD, Bcl-2, Galectin-3, and RACK1, which together with ANXA7 regulate cell proliferation and metastasis [8,[11][12][13][14][15]. In our laboratory, we used immunoprecipitation combined with mass spectrometry to identify proteins that interact with ANXA7 in mouse hepatoma cells, including LEPR (unpublished data).…”

Section: Discussionmentioning

confidence: 99%

“…In hepatocellular carcinoma, ANXA7 can promote the proliferation and migration of HCC through the MAPK/ERK signalling pathway [10]. Moreover, ANXA7 interacts with various proteins, such as ALG-2, SODD, Bcl-2, galectin-3, and RACK1, which together with ANXA7 regulate cell proliferation and metastasis [8,[11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7

et al. 2021

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Background Leptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. However, the role of LEPR and its underlying mechanisms in lymphatic metastasis of hepatocarcinoma have not yet been studied. Methods We performed bioinformatics analysis, qRT-PCR, western blotting, immunohistochemistry, immunofluorescence, enzyme-linked immunosorbent, coimmunoprecipitation assays and a series of functional assays to investigate the roles of LEPR in hepatocellular carcinoma. Results We discovered that LEPR was highly expressed in liver cancer tissues, and the expression of LEPR in Hca-F cells was higher than that in Hca-P cells. Furthermore, LEPR promotes the proliferation, migration and invasion and inhibits the apoptosis of hepatocarcinoma lymphatic metastatic cells. Further studies indicated that LEPR interacts with ANXA7. Mechanistically, LEPR regulated ERK1/2 and JAK2/STAT3 expression via ANXA7 regulation. Conclusions These findings unveiled a previously unappreciated role of LEPR in the regulation of lymphatic metastatic hepatocellular carcinoma, assigning ANXA7-LEPR as a promising therapeutic target for liver cancer treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7

et al. 2021

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“…Last yet important, sorcin was also upregulated in vincristine-resistant HOB1 lymphoma cells, but the mechanism is yet uncertain 17,61…”

Section: Functions In Neoplastic Diseasesmentioning

confidence: 99%

“…Sorcin affects the functions of P-gp by the regulation of cellular calcium levels and the phosphorylation of P-gp. It suggests that sorcin can be a potential target for cancer diagnoses, treating strategies and predictions 17…”

Section: Introductionmentioning

confidence: 99%

<p>Sorcin: a novel potential target in therapies of cancers</p>

Zhou¹,

Chen

2019

CMAR

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Soluble resistance-related calcium-binding protein (sorcin) is a member of the penta-EF-hand protein family. Sorcin is widely distributed in normal human tissues, such as the brain, heart, lymphocytes, kidneys, breast and skin. Findings suggest that sorcin is associated with the regulation of calcium homeostasis, cell cycle and vesicle trafficking. It has been reported that many types of non-neoplastic diseases such as diabetes, viral infection, infertility, and nervous system diseases were affected by the expression of sorcin. One of the main issues is the role of sorcin in neoplastic diseases. Research proved that sorcin can be found to overexpress in cells of several cancers, particularly in the case of multidrug-resistant cancers. Additionally, the researchers proposed that the expression of sorcin was significantly associated with the foundation of multidrug resistance (MDR). All the findings mentioned above emphasized the importance of studying sorcin. This review mainly includes the following aspects: functions of sorcin, role in non-neoplastic and neoplastic diseases, and research related to drugs. To sum up, sorcin is a potential novel target to be studied to deal with MDR.

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