Soluble RAGEs — Prospects for treating &amp; tracking metabolic and inflammatory disease

Schmidt, Ann Marie

doi:10.1016/j.vph.2015.06.011

Cited by 81 publications

(86 citation statements)

References 69 publications

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“…Most sRAGE assays, including that reported here, measure both sRAGE and esRAGE. The hypothesis that sRAGE levels might attenuate disease severity/pathology has led to a focus on potential therapeutic sRAGE interventions (see review by [61]). …”

Section: Discussionmentioning

confidence: 99%

Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer’s Disease

Ferguson

Panos

Sloper

et al. 2017

JAD

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Abstract.Background: Alzheimer's disease (AD) presents with an earlier onset age and increased symptom severity in African Americans and Hispanics. Objective: Although the prevalence of plaques and tangles may not exhibit ethnicity-related differences, levels of neurodegenerative proteins have not been described. Methods: Here, levels of five proteins (i.e., S100B, sRAGE, GDNF, A␤ 40 , and A␤ 42 ) and the A␤ 42 /A␤ 40 ratio were measured in postmortem samples of the middle temporal gyrus (BA21) from age-matched African Americans and Caucasians with AD (n = 6/gender/ethnicity). Results: S100B levels were increased 17% in African Americans (p < 0.003) while sRAGE was mildly decreased (p < 0.09). A␤ 42 levels were increased 121% in African Americans (p < 0.02), leading to a 493% increase in the A␤ 42 /A␤ 40 ratio (p < 0.002). Analysis of GDNF levels did not indicate any significant effects. There were no significant effects of gender and no significant ethnicity with gender interactions on any analyte. Effect size calculations indicated "medium" to "very large" effects. Conclusion: S100B is typically elevated in AD cases; however, the increased levels in African Americans here may be indicative of increased severity in specific populations. Increased A␤ 42 /A␤ 40 ratios in the current study are compatible with increased disease severity and might indicate increased AD pathogenesis in African Americans. Overall, these results are compatible with a hypothesis of increased neuroinflammation in African Americans with AD.

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Section: Discussionmentioning

confidence: 99%

Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer’s Disease

Ferguson

Panos

Sloper

et al. 2017

JAD

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“…Besides the changes in protein function conferred by MG modifications, MG adducts exert cellular effects by interacting with the cell surface receptor RAGE (80,81). We observed that RAGE transcript levels were increased in 430 nm exposed Abca4 Ϫ/Ϫ and Rdh8 Ϫ/Ϫ /Abca4 Ϫ/Ϫ mutant mice.…”

Section: Discussionmentioning

confidence: 83%

Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition

Zhou

Ueda

Zhao

et al. 2015

Journal of Biological Chemistry

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Background:The origin of adduct-forming and cross-linking species in aging Bruch's membrane of the eye is unclear. Results: Mechanistic studies indicate links between photodegradation of bisretinoids of retinal pigment epithelial (RPE) cells and dicarbonyl adduct deposition. Conclusion: Dicarbonyl release from overlying RPE may be a factor in Bruch's membrane deposition. Significance: These processes could contribute to age-related macular degeneration.

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“…Therefore, even though the present results may not be generalizable to all PCOS patients, the sRAGE differential between PCOS and non-PCOS patients may be greater than indicated. As decreased sRAGE is involved in the development of many diseases [23][24][25], we predict that decreased sRAGE plays a role in the mechanism of PCOS.…”

Section: Discussionmentioning

confidence: 95%

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

Asan

Hao

Yang

et al. 2016

J Assist Reprod Genet

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Purpose To explore the relationships between the soluble receptor for advanced glycation endproducts (sRAGE) and the outcome parameters following in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) and investigate the protective effect of sRAGE in PCOS development regarding inflammation. Methods We conducted a prospective analysis of a subsample of 74 participants from the Reproductive Medical Center of the First Affiliated Hospital of Zhengzhou University. We quantified sRAGE, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α), interleukelin-6 (IL-6), and C-reactive protein (CPR) protein levels in the follicular fluid from 39 PCOS and 35 non-PCOS reproductive-age women. sRAGE and VEGF, TNF-α, IL-6, and CRP in follicular fluid aspirated without blood were measured by ELISA. Results sRAGE concentrations in the follicular fluid were significantly lower in the PCOS group compared to those in the control group, while VEGF, TNF-α, IL-6, and CRP concentrations were significantly higher in the PCOS group than in the control group (P < 0.05). sRAGE was significantly, inversely correlated with the total dose of gonadotropin (Gn) in the PCOS group undergoing IVF treatment (r = −0.451, P = 0.004). After adjusting for age and Gn dose (in international units used per cycle), sRAGE protein levels in the follicular fluid were significantly, inversely related to VEGF (r = −0.378, P = 0.018), TNF-α (r = −0.450, P = 0.004), IL-6 (r = −0.455, P = 0.004), and CRP (r = −0.375, P = 0.019). Conclusion sRAGE in the follicular fluid might exert a protective effect against the inflammatory action of PCOS development.

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Soluble RAGEs — Prospects for treating & tracking metabolic and inflammatory disease

Cited by 81 publications

References 69 publications

Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer’s Disease

Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer’s Disease

Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

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