Soluble Polymers as Scaffolds for Recoverable Catalysts and Reagents

Synthesis of MeO-PEG-Supported Ferrocenyloxazoline Ligands and Their Application in Asymmetric Catalysis

“…So soluble polymer-reagents and catalysts have achieved wide recognition and acclaim because that reactions are carried out homogeneously which can lead to the higher rates and better enantioselectivities than catalysts immobilized on solids, and catalyst could be separated from the reaction mixture by filtration, precipitation or extraction. [2,3] As soluble polymer modified poly(ethylene glycol)s (PEGs) recently emerged as readily functionalized, commercially available polymers that are soluble in some solvents and insoluble in a few other solvents for example ether and n-hexane. [4][5][6][7][8][9][10][11][12][13] Recently, the monomethyl ether of PEG (MeO-PEG) has successfully being used for supporting chiral ligands to be transformed in catalysts for some catalytic asymmetric reactions.…”

Liquid phase organic synthesis of 3,5-disubstituted 1,3,5-thiadiazinane-2-thione derivatives on polyethylene glycol (PEG) support

“…It is an inexpensive polymer and an ideal support for liquid-phase combinatorial synthesis because it is easy to functionalize and also resistant to drastic operative conditions. 4 Furthermore, it is soluble in many organic solvents, such as CH 2 Cl 2 , CHCl 3 , tetrahydrofuran (THF), CH 3 OH, or H 2 O at room temperature and it can be precipitated from a solution by addition of diethyl ether, tert-butyl methyl ether, propan-2-ol, or hexane. 5 Due to these features, PEG chemistry has shown a broad-based application, which may be in large part ascribed to the use of PEG-conjugates to deliver drugs, oligonucleotides or enzymes.…”

Poly Ethylene Glycols as Efficient Media for the Synthesis of <i>β</i>-Nitro Styrenes from <i>α</i>, <i>β</i>-Unsaturated Carboxylic Acids and Metal Nitrates under Conventional and Non-Conventional Conditions

“…Recently we have concentrated on developing new methodologies using non-conventional energy sources and eco-friendly materials as catalysts in organic transformations, and reported a methodology in metal ion mediated nitration of organic compounds in presence of small amount of HNO 3 under solvent free (solid state) conditions [28]. Polyethylene glycol (PEG-400) is a biologically acceptable inexpensive polymer and an ecofriendly reagent [29], which is widely used in many organic reactions for conversion of oxiranes to thiiranes [30], asymmetric aldol reactions [31], cross-coupling reactions [18], Baylis-Hillman reaction [32,33] and ring opening of epoxides [34]. Encouraged by these results, we want to explore, the use of Polyethylene glycols (PEGs) as efficient catalyst in this study.…”