Soluble PECAM-1, but Not P-Selectin, Nor Osteonectin Identify Acute Myocardial Infarction in Patients Presenting with Chest Pain

Abstract

We sought to determine plasma levels of platelet/endothelial cell adhesion molecule-1 (PECAM-1), P-selectin, and platelet-derived osteonectin, and prospectively compare these data with the discharge diagnosis in patients presenting with chest pain in a community hospital Emergency Department. Soluble antigens were measured by ELISA in 44 subjects including patients with acute myocardial infarction (AMI) (n = 13), chest pain of noncardiac origin (n = 17), and compared to those of age- and sex-matched healthy controls (n = 14). Elevated soluble PECAM-1 (64.5 ± 18.3 ng/ml, p = 0.019), but not P-selectin (149.5 ± 49.8 ng/ml, p = NS), nor osteonectin (549.5 ± 159.1 ng/ml, p = NS), occurred in the AMI group as compared to patients with noncardiac chest pain (46.2 ± 7.5 ng/ml, 118.2 ± 40.1 ng/ml, and 619.4 ± 74.4 ng/ml, respectively). Increased plasma PECAM-1 may serve as a useful marker in the early detection of patients with AMI. Larger studies will be necessary to confirm the utility of soluble PECAM-1 in identifying AMI among patients presenting with chest pain.

Leucine125Valine (Leu125Val) Gene Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Myocardial Infarction in Indian Population

“…The increase in the sPECAM-1 levels at acute event of MI is in consistent with its role in atherosclerosis and thrombosis. Similar finding has been reported by Serebruany et al [21] and Soeki et al [22]. The decreased levels of sPECAM-1 observed in treated MI patients in the present study may be accounted by the intense medical treatment received by these patients and that their blood sample was collected on an average 4.5 days from the stabilization of their symptoms.…”

In Search for Novel Biomarkers of Acute Coronary Syndrome

“…It has also been demonstrated to have role in plaque formation and thrombosis (Newman et al, 1990, Mahooti et al, 2000. In our study there was significant increase in sPECAM-1 in AMI patients at acute event consistent with the finding of Serebruany et al (1999b) and Soeki et al (2003).…”

Platelet Activation in Cats with Hypertrophic Cardiomyopathy

“…In both platelets and endothelial cells, PECAM‐1 is shed into the plasma after proteolytic cleavage of its ectodomain. sPECAM‐1 is consistently and significantly increased in humans with acute myocardial infarction, as well as in patients with congestive heart failure independent of disease origin 35, 36. Similar results have been documented by Soeki et al, who suggested that increased sPECAM‐1 concentrations may be a sensitive marker for the early diagnosis of acute cardiac disease in humans 35.…”