Soluble P-selectin as a Biomarker for Infection and Survival in Patients With a Systemic Inflammatory Response Syndrome on the Intensive Care Unit

Abstract

Aims:This study investigated the ability of soluble platelet selectin (sP-selectin) to identify infection and predict 30-day mortality in patients with a systemic inflammatory response syndrome (SIRS) on the intensive care unit.Methods:Soluble platelet selectin levels were measured daily in the first 48 hours in patients presenting with SIRS. The outcome, proven infection, was established using predefined definitions. The 30-day mortality was retrospectively assessed.Results:In a total of 313 patients with SIRS, sP-selectin levels were measured. Of these, 114 patients had proven infection on admission or developing during their intensive care unit (ICU) stay. Patients with proven infection had moderately higher levels of sP-selectin (147 ng/mL; interquartile range [IQR], 93.4-203 ng/mL) compared with noninfected patients (143.8 ng/mL; IQR, 89.6-194.7 ng/mL). This difference was not statistically significant (P = .072). However, in patients who were not admitted for infection (n = 235), sP-selectin levels were significantly related to the subsequent development of infection (P = .013). Soluble platelet selectin levels were particularly high in patients with abdominal sepsis and skin infections. Higher sP-selectin levels were associated with higher mortality (although not statistically significant, P = .08).Conclusions:This study shows that in patients with SIRS not admitted for infection, sP-selectin levels are significantly related to the subsequent development of infection. Furthermore, patients with higher sP-selectin levels in the first 2 days of admission had higher 30-day mortality, although this association is not statistically significant. Therefore, we conclude that sP-selectin is a potential future biomarker for both mortality and infection in patients with SIRS, but more research is needed to confirm its prognostic role.

Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation

“…Although elevated plasma sP-selectin, together with increased plasma glycocalyx-degradation products, was highly suggestive of endothelial activation/injury, we cannot exclude platelet activation as an additional source of sP-selectin. Nevertheless, sP-selectin has been shown to be an important biomarker in several inflammatory/procoagulopathy diseases including systemic inflammatory response syndrome ( 37 , 43 , 44 ).…”

Elevation of C-reactive protein, P-selectin and Resistin as potential inflammatory biomarkers of urogenital Schistosomiasis exposure in preschool children

“…Studies have linked inflammatory biomarkers to various diseases; resistin has been linked with diabetes [13], CRP with malaria [12] and P-selectin with systemic inflammatory response syndrome [23]. However, there is paucity of data on their role in schistosomiasis.…”

Effectiveness of Grounded Sleeping on Recovery After Intensive Eccentric Muscle Loading

“…Our assumption that grounded sleeping dampens inflammation is further supported by a general decrease of inflammation markers observed in the GRD group. Of note, the sCAM sP-selectin (Schrijver et al, 2017) remained below the baseline level in the GRD group throughout the observation period, suggesting that grounded sleeping has a beneficial and long-lasting effect on this inflammation marker. sP-selectin is found on activated endothelial cells and platelets and is a crucial factor for leukocyte recruitment to lesion sites (Cleator et al, 2006).…”