Soluble P‐selectin and the postoperative course following cardiopulmonary bypass in children

Lotan, Danny; Prince, Tal; Dagan, Ovadia; Keller, Natan; Ben‐Abraham, Ron; Weinbroum, Avi A.; Gaby, Alan R.; Augarten, Arie; Smolinski, A.; Barzilay, Zohar; Paret, Gideon

doi:10.1046/j.1460-9592.2001.00663.x

Cited by 10 publications

(5 citation statements)

References 28 publications

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“…10,11 Recently, sP-selectin levels were found to correlate with increased postoperative mortality risk score, hypotension, and tachycardia in children undergoing CPB. 12 However, our data show no relationship between sP-selectin levels and the clinical data. The sP-selectin levels rose postoperatively and a significant increase was detected even 20 hours after CPB, but no difference was found between sP-selectin levels in patients who needed norepinephrine in the ICU and the control patients.…”

Section: Discussioncontrasting

confidence: 71%

Soluble Adhesion Molecules in Coronary Artery Bypass Surgery

Wei

Laurikka²,

Kuukasjärvi³

et al. 2003

Asian Cardiovasc Thorac Ann

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Plasma levels of sE-selectin, sP-selectin, and sICAM-1 were measured before anesthesia and at 0.5, 4, and 20 hours after cardiopulmonary bypass in 37 men undergoing coronary artery bypass surgery. Plasma sE-selectin remained close to the preoperative levels. The levels of sP-selectin increased significantly from 46.5 +/- 15.3 ng x mL(-1) to 69.3 +/- 39.6 ng x mL(-1) at 0.5 hours, 84.1 +/- 45.5 ng x mL(-1) at 4 hours, and 79.6 +/- 35.5 ng x mL(-1) at 20 hours. Plasma sICAM-1 levels decreased 0.5 hours after cardiopulmonary bypass, recovered at 4 hours, and showed a significant increase at 20 hours. The changes in plasma levels of adhesion molecules did not correlate with the duration of bypass or aortic crossclamping, hemodynamics, or creatine kinase-MB levels. However, sE-selectin and sICAM-1 levels increased considerably more in patients who needed norepinephrine in the intensive care unit. These results indicate that the transient changes in plasma levels of soluble adhesion molecules are not associated with postoperative myocardial injury in low-risk coronary grafting, although they correlate with the need for a vasopressor.

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Section: Discussioncontrasting

confidence: 71%

Soluble Adhesion Molecules in Coronary Artery Bypass Surgery

Wei

Laurikka²,

Kuukasjärvi³

et al. 2003

Asian Cardiovasc Thorac Ann

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“…It was found that sP-selectin levels correlated with the postoperative "pediatric risk of mortality"-score, hypotension and tachycardia in children undergoing CPB (16). In agreement with previous studies (17,18), sP-selectin increased after CABG in the present study.…”

Section: Discussionsupporting

confidence: 92%

Soluble Adhesion Molecules in Coronary Surgery and Cardiopulmonary Bypass with Pump Prime Aprotinin

Wei

Laurikka

Kuukasjärvi

et al. 2002

Scandinavian Cardiovascular Journal

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“…Most earlier works which had studied inflammatory indices after CPB measured these mediators only in the acute postoperative period (1–5). We recently conducted an investigation in which we monitored plasma soluble P‐selectin in paediatric patients who had a complicated course following CPB, and our results suggested that it might be used as a marker to predict the postoperative course (14). Our current study had a twofold purpose: to look for a possible association between IL‐8 levels with morbidity and mortality during the early postoperative course in infants or children after undergoing CPB and to compare IL‐8 levels in those children who had a complicated course immediately postoperatively to those whose course was unremarkable.…”

Section: Discussionmentioning

confidence: 99%

Interleukin‐8 secretion following cardiopulmonary bypass in children as a marker of early postoperative morbidity

Ben‐Abraham

Weinbroum

Lotan

et al. 2002

Pediatric Anesthesia

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There was an association between IL-8 and early postoperative heart rate, and the need for inotropic support IL-8 correlated positively with surgical time, CPB time and heart rate and negatively with pH. IL-8 release may be related to some of the haemodynamic changes in the early postoperative course following CPB. The relationship between IL-8 and late markers of patient outcome in high-risk infants awaits further studies.

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Soluble P‐selectin and the postoperative course following cardiopulmonary bypass in children

Cited by 10 publications

References 28 publications

Soluble Adhesion Molecules in Coronary Artery Bypass Surgery

Soluble Adhesion Molecules in Coronary Artery Bypass Surgery

Soluble Adhesion Molecules in Coronary Surgery and Cardiopulmonary Bypass with Pump Prime Aprotinin

Interleukin‐8 secretion following cardiopulmonary bypass in children as a marker of early postoperative morbidity

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