Soluble lutein in combination with brilliant blue as a new dye for chromovitrectomy

Badaró, Emmerson; Furlani, Bruno; Guerra, Ricardo Luz Leitão; Maia, Maurício; Lima, Acácio; Souza-Martins, Diogo; Muccioli, Cristina; Lucatto, Luiz Filipe Adami; Belfort, Rubens

doi:10.1007/s00417-013-2539-5

Cited by 14 publications

(16 citation statements)

References 22 publications

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“…Recently, our group reported use of lutein-based dyes as an alternative for ILM dyeing, with good staining ability and good safety profiles [5][6][7]24]. Future research on the healing process in MH surgery to compare dyes for ILM peeling and innovative adjuvants to improve the healing process and investigate substances that may be helpful to stimulate photoreceptors growth will facilitate understanding and optimize better treatment for MHs.…”

Section: Discussionmentioning

confidence: 99%

“…A variety of dyes including trypan blue, Brilliant Blue, and luteinbased dyes can be used to aid visualization of the ILM [5][6][7]. The dyes have varying degrees of ILM specificity and may be used sequentially to peel ERMs, if present, and then ILMs [8,9].…”

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

“…Brilliant Blue is a blue anionic aminotriarylmethane chemical compound with affinity for staining the ILM with small acceptable signs of toxicity [10]. In humans, Brilliant Blue produced appropriate ILM staining in an isoosmolar solution of 0.25 mg/ml when used for idiopathic ERMs and MHs [5][6][7][8][9][10].…”

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

“…The first surgical procedure to repair MHs by relieving VMT and promoting re-apposition of the MH edges was reported in 1991 [4]. Surgery for MHs typically includes removal of any epiretinal membranes (ERMs) and peeling of the ILM, with or without use of vital dyes to aid visualization [5][6][7][8][9][10]. Vitreous substitutes are usually used at the end of surgery as intraocular tamponade and they include octafluoropropane (C3F8), sulfur hexafluoride (SF6), silicon oil, or filtered air.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Management of Macular Hole at 2 Years of Follow-Up

Badaró¹,

Navarro²,

Lima-Sousa³

et al. 2015

J Clin Exp Ophthalmol

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Purpose: To determine prognostic factors, anatomic success rate and safety of sutureless pars plana vitrectomy and vitreous base removal associated to internal limiting membrane (ILM) peeling, C3F8 injection and 1-day facedown postoperative positioning to manage idiopathic macular holes (MHs) at 2 years follow-up.Methods: Forty-six eyes with an idiopathic MH underwent pars plana vitrectomy, ILM peeling after Brilliant Blue 0.05 mg/ml staining, and gas tamponade. Patients remained facedown for 1 day postoperatively. Follow-up included measurement of best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) at 1 and 7 days and 1, 6, 12, and 24 months postoperatively. If the MHs were not anatomically closed by 1 month, another procedure was performed.Results: Primary and final anatomical closure rate were 91.3% and 97.8%, respectively. Mean BCVA improvement (logarithm of the minimum angle of resolution, LogMAR) was 0.34. No late MH reopening occurred, no surgery-related or ocular dye-related complications developed. The BCVA was less likely to improve in MHs with longer symptomatic periods or larger internal diameters. Conclusion:Pars plana vitrectomy combined with vitreous base removal and ILM peeling using Brilliant Blue 0.05% associated to C3F8 injection and 1-day facedown postoperative positioning for idiopathic MHs is a safe surgical approach, achieving a MH closure rate of 91.3% after one procedure and 97.8% after a second one. Long symptoms duration and larger inner MH diameter are associated with poor BCVA.Keywords: Chromovitrectomy; Brilliant Blue; Macular hole; Vital dyes; Vitrectomy Summary StatementSutureless pars plana vitrectomy associated to posterior hyaloid detachment, internal limiting membrane peeling guided by brilliant blue, staining vitreous base removal, C3F8 injection and 1-day facedown postoperative positioning is a safe and effective surgical technique for management of macular holes.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical Management of Macular Hole at 2 Years of Follow-Up

Badaró¹,

Navarro²,

Lima-Sousa³

et al. 2015

J Clin Exp Ophthalmol

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“…Vitreoretinal surgeons know that a good visualization in any surgery step is essential for our success, that is why we have been staining the vitreous with triamcinolone or lately with Triessence or other stains to visualize better the vitreous strands and their distribution [1-3]. This new technique described here is much better and easier than the other previously described vitreous stains, because it not only stains the vitreous but also shows how the dissection of the posterior hyaloid proceeds and as this dye is the one used to stain the epiretinal macular membrane (ERM) or internal limiting membrane (ILM) it does not add any extra cost or steps.…”

Section: Introductionmentioning

confidence: 99%

Posterior Hyaloid Dissection: Let’s Make It Easy with Blue

et al. 2018

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Purpose: Our aim is to present in this online supplementa ry video (see www.karger.com/doi/10.1159/000486348) an easy new surgical technique using blue dye to dissect the posterior hyaloid when performing pars plana vitrectomy. Procedures: Dual-Blue stain is injected in vitreous cavity just after central vitrectomy is performed. The distribution of the blue stain will allow us to know if there is a posterior vitreous detachment or not (“blue lake fashion” or “blue jelly fashion,” respectively) and as an excellent visualization of the vitreous fibers is accomplished, dissection of the posterior hyaloid can be performed without difficulty. Results: This procedure allows a much more simple, fast, and safe dissection of posterior hyaloid even for an inexperienced vitreoretinal surgeon. The cleavage plane between the retina and the posterior hyaloid is easily differentiated. Conclusions: A more controlled and easy dissection of posterior hyaloid during vitrectomy is accomplished with this simple technique without adding any extra cost. Message of the paper: An easy technique that allows a much easier dissection of the posterior hyaloid during vitrectomy improving visualization and decreasing risks. No extra cost, nor time is needed.

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