Soluble LRIG2 is a potential biomarker for type 2 diabetes mellitus

Abstract

Background: Early diagnosis and treatment of type 2 diabetes can delay the onset of microvascular and macrovascular complications. Therefore, the identification of a novel biomarker for diagnosing diabetes is necessary. In the present study, the role of serum soluble leucine-rich repeats and immunoglobulin like domains 2 (sLRIG2) was investigated as a diagnostic biomarker of type 2 diabetes.Methods: A total of 240 subjects with newly diagnosed type 2 diabetes (n=80), prediabetes (n=80), or normal glucose tolerance (NGT; n=80) were included in this study. The fasting serum sLRIG2 level was measured using a quantitative sandwich enzyme immunoassay technique with an enzyme-linked immunosorbent assay (ELISA). Serum sLRIG2 levels were compared among the three groups, and the associations of serum sLRIG2 levels with clinical variables were investigated.Results: Serum sLRIG2 levels were significantly higher in subjects with type 2 diabetes (16.7±8.0 ng/mL) than in subjects without diabetes (NGT group: 12.3±5.3 ng/mL, P<0.001; prediabetes group: 13.2±5.8 ng/mL, P=0.002). Glycosylated hemoglobin (HbA1c: r=0.378, P<0.001) and blood glucose (fasting: r=0.421, P<0.001;2-hour postprandial: r=0.433, P<0.001) correlated more strongly with sLRIG2 than any other clinical variables. Conclusions:The serum sLRIG2 levels correlated with glucose parameters; thus, sLRIG2 might be a novel diagnostic biomarker for type 2 diabetes.

Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians

“…In our study, we found that there was proportionate increase in NLR with increase in 24 hours urine albumin excretion. Similar to our finding, Kahraman et al [30] found a linear relationship between NLR and 24 hours urine albumin excretion. In our study, there was a linear positive correlation between serum creatinine and NLR.…”

“…Kahraman et al . [ 30 ] reported that there was a significant positive correlation between NLR and serum creatinine in their study. In the present study, patients with low eGFR had high NLR levels.…”

“…Similar to our finding, Kahraman et al . [ 30 ] found a linear relationship between NLR and 24 hours urine albumin excretion. In our study, there was a linear positive correlation between serum creatinine and NLR.…”

Neurogenic Defects Occur in LRIG2-Associated Urinary Bladder Disease

“… 21 Full length LRIG2 is a plasma membrane protein but a soluble cleaved form has also been described. 38 LRIG2 enhances tumor growth in diverse tissues, including brain and skin, a property conferred in part by modulating growth factor signaling. 22 , 39 , 40 Mouse studies have also implicated LRIG2 in axon guidance during central nervous system development and regeneration.…”

Neurogenic defects underlie functional bladder outflow tract obstruction associated with biallelic variants inLRIG2

“…Homozygous Lrig2 or Hpse2 mutant mice both have abnormally patterned bladder nerves (Roberts et al, 2019). Full length LRIG2 is a plasma membrane protein but a soluble cleaved form has also been described (Kim et al, 2021). LRIG2 enhances tumour growth in diverse tissues, including brain and skin, a property conferred in part by modulating growth factor signaling (Rondahl et al, 2013;Dong et al, 2020;Hoesl et al, 2019).…”