Soluble Leukocyte Selectin in the Analysis of Pleural Effusions

Horvath, Lynn L.; Gallup, Roger A.; Worley, Brian D.; Merrill, Gerald A.; Morris, Michael J.

doi:10.1378/chest.120.2.362

Cited by 3 publications

(1 citation statement)

References 22 publications

(39 reference statements)

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“…After systematically searching literature databases and manually searching references lists in relevant reviews and studies, we included 20 studies examining the diagnostic accuracy of cholesterol levels in patients with pleural exudates [16-35]. Studies were excluded mainly because they did not examine diagnostic performance, they did not report sufficient data to construct 2 × 2 tables, or they involved fewer than 20 patients.…”

Section: Resultsmentioning

confidence: 99%

Can cholesterol be used to distinguish pleural exudates from transudates? evidence from a bivariate meta-analysis

et al. 2014

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BackgroundMany studies have investigated whether pleural cholesterol levels can aid in diagnosis of pleural exudates, and the results have varied considerably. To gain a more reliable answer to this question, we meta-analyzed the literature on using pleural cholesterol or the ratio of cholesterol in pleural fluid to cholesterol in serum (P/S cholesterol ratio) as diagnostic tests to help identify pleural exudates.MethodsLiterature databases were systematically searched for studies examining accuracy of pleural cholesterol or P/S cholesterol ratios for diagnosing pleural exudates. Data on sensitivity, specificity, positive/negative likelihood ratio (PLR/NLR), and diagnostic odds ratio (DOR) were pooled using bivariate-effects models. Summary receiver operating characteristic (SROC) curves and area under the curve (AUC) were used to summarize overall test performance.ResultsOur meta-analysis included up to 20 studies involving 3,496 subjects. Summary estimates for pleural cholesterol in the diagnosis of pleural exudates were as follows: sensitivity, 0.88 (95%CI 0.84 to 0.92); specificity, 0.96 (95% CI 0.92 to 0.98); PLR, 20.31 (95% CI 11.21 to 36.78); NLR, 0.12 (95% CI 0.09 to 0.17); DOR, 167.06 (95% CI 76.79 to 363.95); and AUC 0.97 (95% CI 0.95 to 0.98). The corresponding summary performance estimates for using the P/S cholesterol ratio were as follows: sensitivity, 0.94 (95% CI 0.92 to 0.96); specificity, 0.87 (95% CI 0.83 to 0.91); PLR 7.46 (95% CI, 5.47 to 10.19); NLR, 0.07 (95% CI 0.05 to 0.10); DOR, 107.74 (95% CI 60.91 to 190.60); and AUC 0.97 (95% CI 0.95 to 0.98).ConclusionsBoth pleural cholesterol level and the P/S cholesterol ratio are helpful for the diagnosis of pleural exudates. Nevertheless, the results of pleural cholesterol assays should be interpreted in parallel with the results of traditional tests and clinical information.

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Section: Resultsmentioning

confidence: 99%